Does insulin resistance in type 2 diabetes alter vitamin D status?

Al-Shoumer, Kamal Abdul Aziz Sulaiman; Al-Asoosi, Adnan Ali; Ali, Aida Hussain; Nair, Vasanthy

doi:10.1016/j.pcd.2013.04.008

Cited by 23 publications

(25 citation statements)

References 31 publications

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“…We found a significant weak negative correlation between HbA1C and 25(OH)D, similar to other previously published studies [12, 18, 23, 28, 33, 34]. However glycemic control was not associated with vitamin D when we controlled for confounding factors, as verified by Luo et al and Al-Shoumer et al [35, 36]. …”

Section: Discussionsupporting

confidence: 91%

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Rolim¹,

Santos²,

Conceição³

et al. 2016

Diabetol Metab Syndr

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ObjectivesDetermine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovascular risk.Research design and methodsWe conducted a cross-sectional study with consecutive patients treated at a University Hospital’s Endocrinology outpatient clinic located at 12°58′S latitude, between October 2012 and November 2013. Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL (chemiluminescence).ResultsWe evaluated 108 patients with mean duration of T2DM of 14.34 ± 8.05 years and HbA1c of 9.2 ± 2.1%. Mean age was 58.29 ± 10.34 years. Most were women (72.2%), non-white (89.8%) and had hypertension (75.9%) and dyslipidemia (76.8%). Mean BMI was 28.01 ± 4.64 kg/m2; 75.9% were overweight. The prevalence of hypovitaminosis D was 62%. In multiple logistic regression, independent predictors of hypovitaminosis D were female gender (OR 3.10, p = 0.02), dyslipidemia (OR 6.50, p < 0.01) and obesity (OR 2.55, p = 0.07). In multiple linear regression, only total cholesterol (β = −0.36, p < 0.01) and BMI (β = −0.21, p = 0.04) remained associated with levels of 25-hydroxyvitamin D.ConclusionsUsing currently recommended cutoffs, the prevalence of hypovitaminosis D in Brazilians with T2DM was as high as that of non-tropical regions. Female gender, dyslipidemia and obesity were predictors of hypovitaminosis D. Low levels of 25-hydroxyvitamin D were correlated with high cholesterol and BMI values. Future studies are needed to evaluate whether vitamin D replacement would improve these parameters and reduce hard cardiovascular outcomes.

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Section: Discussionsupporting

confidence: 91%

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Rolim¹,

Santos²,

Conceição³

et al. 2016

Diabetol Metab Syndr

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“…The current study results agree with Al-Shoumer et al, 2013 study carried out in Kuwait showed that mean of vitamin D deficiency in diabetic cases higher than controls (25.4±2.1 vs. 21.6±2) and there was not statistical significant difference [38].…”

Section: Discussionsupporting

confidence: 90%

Vitamin D status Association with newly diagnosed Type2 Diabetes Mellitus: A Case Control Study

Ashiry¹,

Gadallah²,

Mashahit³

et al. 2018

Fayoum University Medical journal

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Diabetes mellitus is one of the most common metabolic diseases in the world that can affect nearly every organ system in the body. Vitamin D has sparked widespread interest in the pathogenesis and prevention of diabetes. The aim of study; to investigate vitamin D level in type 2 diabetes and controls. A retrospective case control study with 47 newly diagnosed diabetic patients aged (35-70 years) and 54 controls matching age±5years and gender. Measuring HbA1c, FBG, assay serum 25(OH) D level were done for patients and/or controls. Results of current study, showed a more severe vitamin D deficiency in newly diagnosed diabetes than controls (46.8% vs.33.3%) and difference between vitamin D level in newly diagnosed diabetes compare to controls was not statistical significant (p=0.108). Conclusion: no statistical significant difference between newly diagnosed diabetes and controls concerning to vitamin D level.

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“…However, whether vitamin D deficiency can be regarded as another manifestation of insulin resistance, or vice versa, remains questionable. Although epidemiologic, cross-sectional, and longitudinal studies have reported associations between metabolic syndrome, diabetes, and vitamin D deficiency, other studies have failed to find any relationship [16,21,37]. With regard to carcinogenesis, one study has reported an additive effect between vitamin D deficiency and insulin resistance, which is similar to our results.…”

Section: Discussionsupporting

confidence: 87%

“…Vitamin D deficiency reportedly increases insulin resistance, although this also remains controversial and vitamin D deficiency should not be regarded as a cause of insulin resistance per se [19][20][21]. The effect of an association between vitamin D deficiency and insulin resistance on carcinogenesis has not been fully investigated, although one study has suggested additive associations in prostate cancer [22].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency Adds an Element of Risk to Insulin Resistance in Colorectal Neoplasms

Baeg

Choi

et al. 2015

Dig Dis Sci

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Does insulin resistance in type 2 diabetes alter vitamin D status?

Cited by 23 publications

References 31 publications

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Vitamin D status Association with newly diagnosed Type2 Diabetes Mellitus: A Case Control Study

Vitamin D Deficiency Adds an Element of Risk to Insulin Resistance in Colorectal Neoplasms

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