“…3 a Schematic representation of the time course of alterations following downhill running (DR) and b current scientific evidence on the benefits of different adaptation strategies to DR (i.e. prior exposure to DR [46,63,67,68,85,92,121,141,143,165,181,184,185,192,193,196,197], preconditioning strategies [16,81], DR training [14,209,210,254], changes in stride pattern [32,67,68,218,219,221,220,228,255], the use of lower limb compression garments [15,236,237], and the use of specific footwear [28,149,253,256]. In a and b, orange, blue, red, purple, and green spheres correspond to isometric MVC force/torque loss, changes in running economy and mechanics, ultrastructural alterations, inflammation and oedema, and muscle soreness, respectively.…”