Does obesity based on body mass index affect semen quality?—A meta‐analysis and systematic review from the general population rather than the infertile population

Wang, SuiYan; Sun, Jun; Wang, Junyi; Ping, Zhiguang; Liu, Li

doi:10.1111/and.14099

Cited by 19 publications

(19 citation statements)

References 54 publications

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“…As a result, mitochondrial malfunction and apoptosis may be the primary cause of decreased sperm motility and viability. Furthermore, we discovered that normal-weight men had somewhat higher sperm motility, normal morphology and viability than overweight and obese men, which these findings are consistent with previous studies (Hofny et al, 2010;La Vignera et al, 2012;Wang et al, 2021). However, sperm count and semen ejaculate volume are similar between groups, which supports previous findings (La Vignera et al, 2012;MacDonald et al, 2013;Öztekin et al, 2020).…”

Section: Discussionsupporting

confidence: 92%

“…Our results revealed that obesity has no effect on sperm volume or concentration, but it has an impact on the proportion of total sperm motility, progressive motility, sperm normal morphology, and viability. The following are some of the processes of obesity that impact sperm quality (Wang et al, 2021): To begin with, obesity causes male reproductive endocrine dysfunction, such as lower testosterone levels (Souteiro et al, 2018), which may be the primary cause of decreased semen volume and total sperm count. Second, inflammatory substances damage the seminiferous epithelium of testicular tissue, which leads to spermatogenesis process impairment in obese men (Leisegang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Relationship between obesity‐related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic

et al. 2022

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Obesity causes many health problems as well as has negative effects on fertility. However, little is known about the association between obesity‐related markers (hip circumference (HC), waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), body fat mass (BFM), skeletal muscle (SM), resting metabolism (RM), visceral fat (VF), and visceral adiposity index (VAI)) and sperm parameters. This cross‐sectional study was conducted on 98 men in three groups: normal‐weight (Nw; body mass index: BMI < 25 kg/m2), overweight (Ow; BMI: 25–29 kg/m2), and obese (Ob; BMI: 30–35 kg/m2) to investigate this issue. The mean WC, HC, WHtR, BFM, SM, RM, and VF were remarkably higher (p < 0.001) for subjects in the Ob group than in Ow and Nw. In Nw, positive correlations were observed between BFM (r = 0.402) and VAI (r = 0.353) and sperm progressive motility (p < 0.05). In Ob males, there was a positive correlation (r = 0.430) between sperm progressive motility and height and a negative relation (r = −0.447) between sperm progressive motility and WHtR. We found the association between serum testosterone (T) levels, T/estradiol ratios, and semen parameters being dependent on obesity‐related markers which confirms the negative effects of obesity on male hormones. In conclusion, WHtR is a valuable parameter in infertility clinics that warrants further studies.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Relationship between obesity‐related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic

et al. 2022

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“…A meta-analysis by Sermondade et al, showed that overweight and obesity were associated with an increased prevalence of azoospermia or oligozoospermia [ 30 ]. Wang et al, selected ordinary obese men rather than infertile patients to conduct a meta-analysis, and the results showed that obesity had no effect on sperm concentration and percentage of normal sperm morphology, but decreased semen volume, total sperm number, percentage of forward progression and percentage of viability [ 31 ], suggesting that obesity affects semen quality to a certain extent, and maintaining normal weight may be one of the effective ways to improve male fertility. The present further included the most updated studies to perform the meta-analysis and demonstrated that obesity and diabetes could both influence the sperm parameters.…”

Section: Discussionmentioning

confidence: 99%

Association of diabetes and obesity with sperm parameters and testosterone levels: a meta-analysis

Zhong

Ji²,

Wang

et al. 2021

Diabetol Metab Syndr

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Background The present study performed two distinct meta-analyses with common outcomes (sperm parameters); one was performed in obese individuals (and non-obese controls) and the other in diabetic individuals (and non-diabetic controls). Methods PubMed, Embase, The Cochrane library, Web of Science, Scopus databases were searched to collect clinical studies related to the effects of obesity and diabetes on male sperm from inception to on 1st February 2021. Statistical meta-analyses were performed using the RevMan 5.4 software. Stata16 software was used to detect publication bias. The methodological quality of the included studies was assessed with the Ottawa–Newcastle scale using a star-based system. Results A total of 44 studies were finally included in the present study, which enrolled 20,367 obese patients and 1386 patients with diabetes. The meta-analysis results showed that both obesity and diabetes were associated with reduced semen volume (obese versus non-obese controls: mean difference (MD) = − 0.25, 95% CI = (− 0.33, − 0.16), p < 0.001; diabetes versus non-diabetic controls: MD = − 0.45, 95% CI = (− 0.63, − 0.27), p < 0.001), reduced sperm count (obese versus non-obese controls: MD = − 23.84, 95% CI = (− 30.36, − 17.33), p < 0.001; diabetes versus non-diabetic controls: MD = − 13.12, 95% CI = (− 18.43, − 7.82), p < 0.001), reduced sperm concentration (obese versus non-obese controls: MD = − 7.26, 95% CI = (− 10.07, − 4.46), p < 0.001; diabetes versus non-diabetic controls: MD = − 11.73, 95% CI = (− 21.44, − 2.01), p = 0.02), reduced progressive motility (obese versus non-obese controls: MD = − 5.68, 95% CI = (− 8.79, − 2.56), p < 0.001; diabetes versus non-diabetic controls: MD = − 14.37, 95% CI = (− 21.79, − 6.96), p = 0.001), and decreased testosterone levels (obese versus non-obese controls: MD = − 1.11, 95% CI = (− 1.92, − 0.30), p = 0.007; diabetes versus non-diabetic controls: MD = − 0.37, 95% CI = (− 0.63, − 0.12), p = 0.004). Conclusions Current evidence suggests that obesity and diabetes negatively affect sperm parameters in men and are associated with low testosterone levels. Due to the limitation of the number and quality of included studies, the above conclusions need to be verified by more high-quality studies.

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“…2 Whilst, the detrimental effects of maternal obesity on pregnancy and foetal outcomes are clearly established, recent research indicates that paternal obesity also detrimentally affects fertility 3,4 and basic sperm parameters such as count, motility and morphology. 5,6 Sperm DNA damage is a specialised marker of sperm quality that is independently associated with recurrent miscarriage, and negative in vitro fertilisation (IVF) outcomes. [7][8][9] The data regarding the association between obesity and sperm DNA damage are currently, however, unresolved.…”

Section: Introductionmentioning

confidence: 99%

Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature

et al. 2023

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Obesity prevalence worldwide is increasing significantly. Whilst maternal obesity has clear detrimental impacts on fertility, pregnancy and foetal outcomes, more recently there has been an increasing focus on the role of paternal obesity in human fertility. Recent meta‐analyses have indicated that obesity in men negatively affects basic sperm parameters such as sperm count, concentration and motility, increases the incidence of infertility and reduces the chances of conception. Sperm DNA damage, typically characterised by DNA strand breaks and oxidation of DNA nucleotides, is a specialised marker of sperm quality that has been independently associated with recurrent miscarriage, reduced assisted reproduction success and increased mutational loads in subsequent offspring. Whilst, there are still conflicting data in humans as to the association of obesity in men with sperm DNA damage, evidence from rodent models is clear, indicating that male obesity increases sperm DNA damage. Human data are often conflicting because of the large heterogeneity amongst studies, the use of body mass index as the indicator of obesity and the methods used for detection of sperm DNA damage. Furthermore, comorbidities of obesity (i.e., heat stress, adipokines, insulin resistance, changes in lipids, hypogonadism and obstructive sleep apnoea) are also independently associated with increased sperm DNA damage that is not always modified in men with obesity, and as such may provide a causative link to the discrepancies amongst human studies. In this review, we provide an update on the literature regarding the associations between obesity in men and fertility, basic sperm parameters and sperm DNA damage. We further discuss potential reasons for the discrepancies in the literature and outline possible direct and indirect mechanisms of increased sperm DNA damage resulting from obesity. Finally, we summarise intergenerational obesity through the paternal linage and how sperm DNA damage may contribute to the transmission.

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Does obesity based on body mass index affect semen quality?—A meta‐analysis and systematic review from the general population rather than the infertile population

Cited by 19 publications

References 54 publications

Relationship between obesity‐related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic

Relationship between obesity‐related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic

Association of diabetes and obesity with sperm parameters and testosterone levels: a meta-analysis

Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature

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