Does Preoperative Transbronchial Biopsy Worsen the Postsurgical Prognosis of Lung Cancer?

Nakajima, Jun; Sato, Hajime; Takamoto, Shinichi

doi:10.1378/chest.128.5.3512

Cited by 19 publications

(15 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there have been reports demonstrating a prognostic disadvantage for biopsy using FFB. [10,11] An observational study revealed that patients who were diagnosed with lung cancer using a trans-pleural technique had a statistically (P = 0.04) better 5-year survival rate than patients diagnosed using TBB. [10] This phenomenon was also reported in a study using propensity score matched analysis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lung cancer biopsy dislodges tumor cells into circulating blood

Sawabata¹,

Kitamura²,

Nitta³

et al. 2017

JCMT

View full text Add to dashboard Cite

Aim:A "seed" of lung cancer metastasis is circulating tumor cells (CTCs), which may be dislodged from a tumor during biopsy. This possibility was assessed among patients who underwent lung tumor biopsy using flexible fiber-topic bronchoscopy (FFB). Methods: The study involved six patients with non-small cell lung cancer who underwent FFB biopsy to diagnose a lesion pathologically (5 males and 1 female, median age 63 years, 6 adenocarcinomas, of 4 clinical-stage IA, 1 stage IB, and 1 stage IIIA), CTCs were extracted from the peripheral vein blood at pre-FFB and at post-FFB using a size selection method. Results: No tumor cell was detected at pre-and post-FFB was in three cases (50%); no tumor cells were detected pre-FFB while CTCs were detected at post-FFB in two cases (33.3%); and CTCs were detected at pre-FFB with numerous CTCs detected at post-FFB in one case (17.7%). In addition, similar tendencies were observed in each analysis of singlecell and clustered-cell categories. Conclusion: These results suggest that a FFB biopsy of lung cancer may potentially dislodge CTCs from a tumor into the circulating peripheral blood. Key words:Lung cancer, biopsy, circulating tumor cells ABSTRACTArticle history:

show abstract

Section: Introductionmentioning

confidence: 99%

“…[10] This phenomenon was also reported in a study using propensity score matched analysis. [11] These results may mean that an intervention in a cancer lesion using TBB may dislodge cancer cells from the lesion to the circulating blood.…”

Section: Introductionmentioning

confidence: 99%

Lung cancer biopsy dislodges tumor cells into circulating blood

Sawabata¹,

Kitamura²,

Nitta³

et al. 2017

JCMT

View full text Add to dashboard Cite

show abstract

“…The TBB procedure was reported in the early 2000s to be an indicator of poor prognosis in patients with resectable non-small cell lung cancer (NSCLC) (1). However, because of the changing demographics of patients with lung cancer, increasing the frequency of early-stage NSCLC (2), we believe that the prognosis for NSCLC patients, after preoperative TBB using BFS, is an important clinical question, and should be reconsidered.…”

mentioning

confidence: 99%

Clinical Implications of Transbronchial Biopsy for Surgically-resected Non-small Cell Lung Cancer

Yasukawa

Sawabata

Kawaguchi

et al. 2018

View full text Add to dashboard Cite

show abstract

“…We have speculated that tumor seeding might start via lacerated capillaries, lymphatic vessels, and/or airway tracts. In a previous study, 17) we retrospectively analyzed whether preoperative brochoscopic biopsy worsened postoperative survival rate and found that stage I NSCLC had a significantly higher recurrence rate if it was preoperatively diagnosed pathologically by transbronchial biopsy rather than not diagnosed preoperatively. This difference was still significant even if the patients were stratified by other clinicopathological risk factors by propensity score.…”

mentioning

confidence: 99%

“…However, the difference between biopsied and non-biopsied groups was not present if the disease was advanced (i.e., stage II or III). 17) CT-guided percutaneous needle biopsy might disrupt the microenvironment in early lung cancer as much as other biopsy methods. On the one hand, tumor implantation around the needle tract in the chest wall is very rare after percutaneous needle biopsy.…”

mentioning

confidence: 99%