Does SARS-CoV-2 re-infection depend on virus variant?

Houhamdi, Linda; Nguyen, Nhu Ngog; Hoang, Van Thuan; Giraud-Gatineau, Audrey; Raoult, Didier

doi:10.1016/j.cmi.2021.06.029

Cited by 9 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this observation should be considered with caution, since it depends on the cumulative number of reinfections that also increases over time. Of note, the risk of reinfection in patients infected during the second wave of COVID-19 in Marseille was 0.08% in our preliminary study [ 6 ], while it was 0.46% in the present study due to the occurrence of new cases of reinfection that were diagnosed after our previous assessment.…”

Section: Discussioncontrasting

confidence: 57%

“…Depending on the epidemic periods, the proportion of reinfection was at 0.61% and 0.08% in patients seen at our institute and primarily infected during the first (from February 2020 to May 2020) and second waves (from mid-June 2020 to February 2021), respectively [ 6 ]. In a preliminary study conducted in our centre in 46 reinfected COVID-19 patients, the proportion of patients with severe/critical status was significantly higher during the second episode than the first (21.2% vs. 5.1%); however, the hospitalization rate, transfer to intensive care unit and lethality did not differ between the two episodes of infection [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

SARS-CoV-2 reinfection and COVID-19 severity

Nguyen

Houhamdi

Hoang

et al. 2022

Emerging Microbes & Infections

Self Cite

View full text Add to dashboard Cite

SARS-CoV-2 reinfection rate is low. The relative severity of the first and second episodes of infection remains poorly studied. In this study, we aimed at assessing the frequency of SARS-CoV-2 reinfections and comparing the severity of the first and second episodes of infection. We retrospectively included patients with SARS-CoV-2 positive RT-PCR at least 90 days after clinical recovery from a COVID-19 episode and with at least one negative RT-PCR after the first infection. Whole genome sequencing and variant-specific RT-PCR were performed and clinical symptoms and severity of infection were retrospectively documented from medical files. A total of 209 COVID-19 reinfected patients were identified, accounting for 0.4% of positive cases diagnosed from 19 March 2020 to 24 August 2021. Serology was performed in 64 patients, of whom 39 (60.1%) had antibodies against SARS-CoV-2 when sampled at the early stage of their second infection. Only seven patients (3.4%) were infected twice with the same variant. We observed no differences in clinical presentation, hospitalization rate, and transfer to ICU when comparing the two episodes of infections. Our results suggest that the severity of the second episode of COVID-19 is in the same range as that of the first infection, including patients with antibodies.

show abstract

Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 reinfection and COVID-19 severity

Nguyen

Houhamdi

Hoang

et al. 2022

Emerging Microbes & Infections

Self Cite

View full text Add to dashboard Cite

show abstract

“…The percentage of re-positive cases we observed before genomic analysis (0.23%) is similar to that observed in other settings ( 26 , 27 ). To consider a case re-positive, we established a threshold of 45 days between 2 SARS-CoV-2–positive RT-PCR tests with > 1 intermediate negative RT-PCR result, although in 69 of our 93 re-positive cases (74.2%), the episodes were >90 days apart.…”

Section: Discussionsupporting

confidence: 89%

Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain

Rodríguez‐Grande¹,

Alcalá²,

Estévez³

et al. 2022

Emerg. Infect. Dis.

View full text Add to dashboard Cite

Estimates of the burden of severe acute respiratory syndrome coronavirus 2 reinfections are limited by the scarcity of population-level studies incorporating genomic support. We conducted a systematic study of reinfections in Madrid, Spain, supported by genomic viral analysis and host genetic analysis, to cleanse laboratory errors and to discriminate between reinfections and recurrences involving the same strain. Among the 41,195 cases diagnosed (March 2020–March 2021), 93 (0.23%) had 2 positive reverse transcription PCR tests (55–346 days apart). After eliminating cases with specimens not stored, of suboptimal sequence quality, or belonging to different persons, we obtained valid data from 22 cases. Of those, 4 (0.01%) cases were recurrences involving the same strain; case-patients were 39–93 years of age, and 3 were immunosuppressed. Eighteen (0.04%) cases were reinfections; patients were 19–84 years of age, and most had no relevant clinical history. The second episode was more severe in 8 cases.

show abstract

“…Then, this variant rapidly became predominant in reinfected patients until the study's endpoint, as of 6 March 2022, with 885 cases out of 1,397 ( Figure 1 ). In earlier studies, we reported that the prevalence of reinfection among SARS-CoV-2 infections diagnosed in our institute was 0.2% (58/29,154 cases), 0.3% (41/12,283 cases) and 1.5% (110/7,152 cases) during the second, third and fourth epidemic (until 24 August 2021), respectively [ 3 , 8 ]. In the present study, we confirm a 1.5% reinfection rate (179/12,135 cases) during the entire fourth epidemic (until November 2021), and observe a marked increase in the reinfection rate that reaches 6.8% (1,397/20,542 cases) during the on-going fifth epidemic ( Figure 2 ).…”

mentioning

confidence: 96%