Does the Schizotypal Personality Questionnaire reflect the biological–genetic vulnerability to schizophrenia?

Vollema, MG; Sitskoorn, Margriet M.; Appels, Melanie C.M.; Kahn, René S.

doi:10.1016/s0920-9964(01)00350-4

Cited by 119 publications

(95 citation statements)

References 16 publications

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“…Interestingly, SPQ scores of relatives in this sample were similar to or lower than relatives' SPQ scores reported in several other studies (Vollema et al, 2002;Yaralian et al, 2000). Relatives involved in the study were willing to participate and were involved in patient caregiving, and the inclusion of these individuals may have resulted in a biased group of relatives that had fewer schizotypal traits.…”

Section: Discussionsupporting

confidence: 61%

Nicotine consumption and schizotypy in first-degree relatives of individuals with schizophrenia and non-psychiatric controls

Esterberg

Jones

Compton

et al. 2007

Schizophrenia Research

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Individuals with schizophrenia have very high rates of cigarette smoking, and much has been discovered about the influence of nicotine on brain functioning in schizophrenia. However, less is understood about the relationship between nicotine consumption and milder phenotypes related to schizophrenia, specifically schizotypy. This study examined the relationship between nicotine consumption and schizotypy in two unmedicated samples that included first-degree relatives and non-psychiatric controls.Forty-two first-degree relatives and 50 control participants were administered a self-report questionnaire on schizotypal features as well as a self-report questionnaire on smoking behavior. A positive relationship was found between smoking status and level of schizotypy, and higher levels of schizotypy significantly predicted the odds of being a smoker after controlling for gender and group status. Interestingly, group status was a significant moderator in the relationship between level of schizotypy and smoking status, such that the relationship between these two variables was only significant in the first-degree relatives. This is the first study to investigate the relationship between these variables in a sample of firstdegree relatives of individuals with schizophrenia. Those individuals with more schizotypal features are presumably at greater risk for schizophrenia-spectrum disorders and thus may be more likely to smoke cigarettes given the known biochemical effects of nicotine on overt positive and negative symptoms of schizophrenia. Although relatives did not differ from controls in their level of selfreported schizotypy, the significant relationship between smoking status and schizotypy in the former group is likely explained by their genetic vulnerability to schizophrenia-spectrum disorders.

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Section: Discussionsupporting

confidence: 61%

Nicotine consumption and schizotypy in first-degree relatives of individuals with schizophrenia and non-psychiatric controls

Esterberg

Jones

Compton

et al. 2007

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…When schizotypy was re-ordered into positive and negative symptomatology, the results showed moderate relationships between attachment anxiety and primarily positive and negative symptomatology, while attachment avoidance was associated only with negative symptomatology. Since the distinction between positive and negative symptoms is an important one, as evidence suggests that the former reflects a genetic vulnerability to schizophrenia (Vollema et al, 2002), our results suggest that attachment Adult attachment and schizotypy 9 anxiety may be more predictive of an individual developing SPD than is attachment avoidance.…”

Section: Discussionmentioning

confidence: 74%

“…When schizotypal traits are present in an individual, but are non-dysfunctional nor prominent enough to manifest psychopathologically, they are grouped under the terms schizotypal personality traits or (healthy) schizotypy (Claridge & Davis, 2003). That said, a person with a schizotypal personality is highly vulnerable to developing SPD or schizophrenia (Cadenhead & Braff, 2002;Gruzelier, 2003;Rossi & Daneluzzo, 2002;Vollema et al, 2002).…”

Section: Schizotypal Personality Disorder (Spd) Is a Disorder Of Clusmentioning

confidence: 99%

The neglected link between adult attachment and schizotypal personality traits

Tiliopoulos¹,

Goodall²

2009

Personality and Individual Differences

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“…[33] Bu konuda yapılan az sayıda çalışmada birbirinden görece bağımsız şizotipi boyutları gösterilmiştir, ancak boyutların sayısı ve içerikleri çalışma-dan çalışmaya değişmektedir. [34,35] Örneğin, şizotipal belirtiler için anormal algılamalar ve inanışlar, içedönüklük, zevk alamama ve dezorganizasyon boyutlarını önerenler olduğu gibi şizofreniye benzer şekilde üç faktör modelini (pozitif, negatif ve nörobilişsel bozukluk) öneren araştırmacılar vardır. [28,36] Farklı boyutların farklı nörobiyolojik temellere dayandığı ve şizofreni ile genetik ilişkileri bakımından da birbirinden ayırdedilebileceği öne sürülmektedir.…”

Section: şIzofreni Spektrumuunclassified

“…Negatif şizotipal özelliklerin şizofreni ile genetik ilişkisi olan bozukluklar spektrumunda incelenmesi gerektiğini ya da yalnızca pozitif boyutun şizofre-niye genetik yatkınlığı yansıttığı belirtilmektedir. [34,37] Boyutsal yaklaşıma göre bu kavram daha genel anlamda özgün olmayan psikoza yatkınlığı ya da psikotizmi düşündürmektedir. [38] Bu açıdan boyutsal yaklaşımla bakıldığında şizotipi, normallikten başlayıp yalnız şizofrenik bozuklukla değil, bipolar ve obsesif kompulsif bozukluk gibi başka patolojik spektrumlarla da sonlanan bir süregenlik durumudur.…”

Section: şIzofreni Spektrumuunclassified

Dimensional Approach in Psychiatry

Özdemir¹

2012

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETPsikiyatride, özellikle şizofreni ve bipolar bozukluk olmak üzere, ruhsal bozuklukların farklı etyolojilere sahip olduğunu ileri süren varsayım geleneksel kategorik yaklaşımı sergiler. Boyutsal yaklaşım ise, ruhsal bozuklukların aslın-da tek bir hastalığın zaman içinde farklı klinik görünümler şeklinde ortaya çıkmasından ibaret olduğunu ileri sürmektedir. DSM ve ICD sistemleri, öteden beri ruhsal bozuklukları ayrı kategoriler olarak ele almış ve öyle sınıf-landırmışlardır. Oysa kategorileri her zaman birbirlerinden ayırmak mümkün olmamaktadır. Hiçbir kategorinin tanımına uymayan, fakat hasta olduğu şüphe götürmeyen, iki kategorinin kısmi özelliklerini bir arada gösteren fakat hiçbirinin ölçütlerini tam olarak karşılamayan hastalar bulunmaktadır. Boyutsal yaklaşım patolojiyi sürekli bir boyut olarak ele alır ve her hastayı bu sürek-liliğin farklı bir noktasına yerleştirir. Bu yaklaşıma göre çoğul tanılar aslında aynı hastalık doğasının farklı boyutlarıdır yaklaşımı ile bir hastanın bütün semptomlarını tek bir hastalıkla açıklayabilmektir. Anahtar Sözcükler: boyutsal yaklaşım, kategorik görüş, psikozun sürekliliği ABSTRACTIn psychiatry there is a traditional categorical conception stating that several disorders like schizophrenia and bipolar disorder have distinct etiologies. On the other hand, dimensional approach claims that these entities are actually the same disorder reflecting different clinical aspects of same mental disorder in the course of time. ICD and DSM classifications are based on separate categories of different mental disorders. Howewer, it is quite difficult to consider a mental disorder as a discrete entity that has absolute boundaries from other disorders. There are patients manifesting symptoms of two or more categories but do not fulfill all diagnostic criteria for any mental disorder. Dimensional approach handles the psychopathology as a continuing process and establish the patients to the different ongoing points. According to this view, in fact, multiple diagnosis reflect dimensions of the same disease.

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Does the Schizotypal Personality Questionnaire reflect the biological–genetic vulnerability to schizophrenia?

Cited by 119 publications

References 16 publications

Nicotine consumption and schizotypy in first-degree relatives of individuals with schizophrenia and non-psychiatric controls

Nicotine consumption and schizotypy in first-degree relatives of individuals with schizophrenia and non-psychiatric controls

The neglected link between adult attachment and schizotypal personality traits

Dimensional Approach in Psychiatry

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