Does University of Wisconsin solution harm the transplanted heart?

Stringham, James C.; Love, Robert B.; Welter, Debbie; Canver, Charles C.; Mentzer, Robert M.

doi:10.1016/s1053-2498(99)00018-2

Cited by 17 publications

(10 citation statements)

References 25 publications

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“…Stringham et al. also demonstrated the UW was proved to be an effective preservative for the heart allografts .…”

Section: Discussionmentioning

confidence: 99%

“…Kur et al reported that myocardial damage was significantly increased among heart allografts with extended ischemic times (>300 min), and UW seems to be effective and safe for myocardial protection in the extended allograft ischemic time (17). Stringham et al also demonstrated the UW was proved to be an effective preservative for the heart allografts (46).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

Guo²,

Liu³

et al. 2015

Artificial Organs

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Organ preservation solution has been designed to attenuate the detrimental effects during the ischemic period. The aim of this study was to systematically evaluate the evidence comparing preservation solutions for heart preservation. Studies were searched in PubMed, Embase, the Cochrane Library, the Transplant Library, and the International Clinical Trials Registry Platform. The primary outcomes were patient survival and donor heart dysfunction. The secondary outcomes were in-hospital mortality and enzyme gene expression. The University of Wisconsin solution (UW) was associated with a significantly improved survival at 30 days and 90 days (hazard ratio = 1.16, 95% confidence interval [CI] = 1.11-1.22, P < 0.00001; risk difference [RD] = 0.03, 95% CI = 0.01-0.05, P = 0.002), compared with Celsior. Hearts preserved with UW exhibited less ischemic necrosis than those preserved with Celsior (RD = -0.07, 95% CI = -0.08 to 0.05, P < 0.00001). UW was associated with better survival compared with histidine-tryptophan-ketoglutarate solution (HTK). There was no statistical difference in donor heart dysfunction and in-hospital mortality outcomes when comparing HTK with Celsior solution. During static cold storage preservation, this study suggests that UW solution has better clinical outcomes for heart transplantation compared with the other two organ preservation solutions. Besides, the protective effect of Celsior solution is similar to HTK solution in donor heart preservation.

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“…Stringham et al. also demonstrated the UW was proved to be an effective preservative for the heart allografts .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

Guo²,

Liu³

et al. 2015

Artificial Organs

View full text Add to dashboard Cite

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“…Preservation with the University of Wisconsin solution (UW) and the improvement in myocardial reperfusion techniques have resulted in less myocardial injury as a result of ischemia and acceptance of non-standard donor hearts [9,10].…”

Section: Introductionmentioning

confidence: 99%

Outcome of hearts with cold ischemic time greater than 300minutes. A case-matched study☆

Mitropoulos

Odim

Marelli

et al. 2005

European Journal of Cardio-Thoracic Surgery

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“…In a previous experimental study of small bowel preservation [13], an initial¯ush with the UW solution using high perfusion pressure increased graft viability compared with low perfusion pressure. Furthermore, donor hearts were¯ushed at a perfusion pressure of 125 mmHg and graft function was preserved well in the report from the University of Wisconsin Hospitals [14]. In regard to an initial¯ush with the UW solution, high pressure may be needed for complete washout and distribution, while low pressure may lead to irregular distribution of the solution.…”

Section: Discussionmentioning

confidence: 91%

Is the UW solution adequate as an initial flush solution for heart procurement? a comparative study of celsior and UW solutions

et al. 2011

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The University of Wisconsin (UW) solution has been widely utilized in the process of organ preservation. Its high potassium content and high viscosity however, have been reported to cause vasoconstriction or endothelial damage during heart procurement. We previously reported that the Celsior solution with its high buer capacity, low potassium content, and low viscosity was equivalent to or superior to the UW solution for cardiac preservation. In this study, myocardial temperature during the washout of coronary vascular beds and myocardial energy metabolism soon after the excision of hearts were evaluated by focusing on the initial¯ush eect of both solutions. Adult mongrel dogs weighing 9.5 to 13.5 kg were used. Following cardiac arrest using cardioplegia, the heart was cooled with ice slush and coronary vascular beds were washed out with a 4°C UW solution (UW group; n = 5) or Celsior solution (Celsior group; n = 5) at a pressure of 80 cm H 2 O. During the period of initial washout using 200 ml of solution, both the myocardial temperature and the time required to reach myocardial temperature of 15°C, were noted. The time required to complete the initial washout was also measured. Phosphocreatine (PCr), û-adenosine triphosphate (ATP) and inorganic phosphate (Pi) levels were measured by using 31 P-nuclear magnetic resonance spectroscopy soon after the excision of hearts. PCr/Pi and û-ATP/Pi values were identi®ed as indicators of myocardial high-energy phosphate levels. The Celsior group tended to require a shorter time to reach a myocardial temperature of 15°C compared with the UW group. The total initial washout time was signi®cantly shorter in the Celsior group than in the UW group. PCr/ Pi and û-ATP/Pi values were signi®cantly higher in the Celsior group than in the UW group. The Celsior solution appears to have signi®cant advantages when used as an initial¯ush solution compared with the UW solution in heart procurement.

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Does University of Wisconsin solution harm the transplanted heart?

Cited by 17 publications

References 25 publications

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

Outcome of hearts with cold ischemic time greater than 300minutes. A case-matched study☆

Is the UW solution adequate as an initial flush solution for heart procurement? a comparative study of celsior and UW solutions

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