2020
DOI: 10.1172/jci98882
|View full text |Cite
|
Sign up to set email alerts
|

Dominant-negative NFKBIA mutation promotes IL-1β production causing hepatic disease with severe immunodeficiency

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

0
18
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 18 publications
(18 citation statements)
references
References 57 publications
0
18
0
Order By: Relevance
“…Although cox1 (investigated in the current study) did not show a significant response to the bacterin across the diets, the FC was significantly correlated with 5loxa and 5loxb . Also, 5loxa and 5loxb were positively correlated to well-known inflammatory and immune-relevant biomarkers (i.e., cxcr1 , irf1 , and nfkbia ) ( Bonelli et al, 2019 ; Mattos et al, 2020 ; Tan et al, 2020 ) ( Figure 5 ). The inter-relationship between cyclooxygenase and lipoxygenase pathways requires further study in teleosts, notably for developing anti-inflammatory therapeutics and diets, especially with the observed higher magnitude of downregulation in both high-18:3ω3 and switched-diet fed groups.…”
Section: Discussionmentioning
confidence: 97%
“…Although cox1 (investigated in the current study) did not show a significant response to the bacterin across the diets, the FC was significantly correlated with 5loxa and 5loxb . Also, 5loxa and 5loxb were positively correlated to well-known inflammatory and immune-relevant biomarkers (i.e., cxcr1 , irf1 , and nfkbia ) ( Bonelli et al, 2019 ; Mattos et al, 2020 ; Tan et al, 2020 ) ( Figure 5 ). The inter-relationship between cyclooxygenase and lipoxygenase pathways requires further study in teleosts, notably for developing anti-inflammatory therapeutics and diets, especially with the observed higher magnitude of downregulation in both high-18:3ω3 and switched-diet fed groups.…”
Section: Discussionmentioning
confidence: 97%
“…Researchers have universally acknowledged that the NF-κB protein complex is required for the initiation of inflammation and the development of immunity [39] . Patients with genetic defects in NFKBIA generally experience severe immunodeficiencies with impaired cellular responses to immune stimuli [40] .…”
Section: Discussionmentioning
confidence: 99%
“…Studies have shown that NFKBIA can not only regulate immune inflammation and tissue damage but also be closely related to the development, differentiation, and migration of immune cells. [53][54][55] In addition, as the most important inhibitor of the nuclear factor kappa B (NF-κB) pathway, NFKBIA usually exists in the mitochondria of the cytoplasm in a relatively static state. Once stimulated by Aβ, NFKBIA will be phosphorylated and degraded, causing NF-κB activation, and leading to AD neuronal degeneration and cognitive impairment.…”
Section: Discussionmentioning
confidence: 99%