Donor-Dependent Developmental Competence of Oocytes from Lambs Subjected to Repeated Hormonal Stimulation1

Ptak, Grazyna; Tischner, M.; Bernabò, Nicola; Loi, Pasqualino

doi:10.1095/biolreprod.102.011312

Cited by 37 publications

(35 citation statements)

References 42 publications

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“…In this study, the treatment of animals with a progestagen (fluorogestone acetate (FGA)), a short while after ovulation, most likely led to an increase in the production of transferable embryos and to improve the repeatability by reducing the deleterious effect of the early regression of CL on embryos (Cervantes et al 2007). The observed high within-animal repeatability indicated that embryo production capacity is intrinsically dependent on the donor goat and agrees with data obtained for cows (Tonhati et al 1999, Asada & Terawaki 2002, Benyei et al 2004, Peixoto et al 2004, Monniaux et al 2010 and sheep (Ptak et al 2003).…”

Section: Discussionsupporting

confidence: 81%

Anti-Müllerian hormone as a predictive endocrine marker for embryo production in the goat

Monniaux¹,

Baril²,

Lainé³

et al. 2011

Reproduction

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Recently, we demonstrated the relationship between anti-Mü llerian hormone (AMH) circulating concentrations, ovarian follicles, and embryo production in cattle. However, they have not yet been established in a species with a seasonal breeding activity. Thus, goats were subjected to repeated in vivo embryo production during the breeding season, at the end of the breeding season, and at the end of the anestrus season. Embryo production after FSH treatment was highly repeatable for each goat. Plasma AMH concentrations, measured before the first FSH treatment, were highly correlated with the number of collected, transferable, and freezable embryos, resulting from the three sessions of embryo production. Plasma AMH concentrations transiently decreased after each exogenous FSH treatment, but they showed little change with season, and no relationship was observed between AMH and endogenous FSH concentrations during seasonal transitions. Follicles of 1-5 mm in diameter were the main target of the FSH treatment and were major contributors to circulating AMH concentrations. Granulosa cell AMH expression decreased as the follicle approached terminal development, while the expression of maturation markers (CYP19A1 and FSHR) increased. In conclusion, circulating AMH concentrations can be predictive of the capacity of a donor goat to produce high or low numbers of high-quality embryos. This prediction could be accurately made from a single blood measurement of AMH during either breeding or anestrus seasons. Variability in the number of gonadotropin-responsive follicles of 1-5 mm in diameter between individuals resulted in the differences in circulating AMH concentrations measured between individuals.

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Section: Discussionsupporting

confidence: 81%

Anti-Müllerian hormone as a predictive endocrine marker for embryo production in the goat

Monniaux¹,

Baril²,

Lainé³

et al. 2011

Reproduction

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“…Similar results have been reported by Al-Kamali et al (25) in ewes. This is in accordance with Ptak et al (29), who found that follicular response declined with repeated stimulation. Therefore, the decrease in ovulations and transferable embryos after repeated treatments might be caused by genital tract adhesion after repeated flushings.…”

Section: Discussionsupporting

confidence: 93%

Repeated superovulation treatments in Kivircik ewes during breeding and nonbreeding seasons

Üstüner¹,

Alçay²,

Nak³

et al. 2014

Turk J Vet Anim Sci

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IntroductionTurkey, which has a great number of endemic species, has an important share in the genetic resources of the earth (1). Kivircik, a sheep breed native to Turkey, has important social and economic value as genetic resources in livestock. Since 1991, the total number of sheep in Turkey has decreased dramatically. While in 1991 there were 39,000,000 head of sheep in Turkey, this number decreased to 25,000,000 in 2012 (2). Therefore, there is a need to develop strategies and methodologies to preserve and support the sustainability of native sheep breeds. Cryopreserved embryos might enable us to bring back sheep from a lost breed. Cryopreserving healthy germ cells and embryos may help to eradicate animal health problems and make use of specific genes in native breeds that might emerge in the future, as well (3,4). Developed countries have sought to preserve threatened breeds by offering financial incentives in the form of grants for the collection and cryopreservation of gametes and embryos (5).Superovulation is the most important step in the conservation of animal genetic resources via in vivo production. Multiple ovulation and embryo transfer (MOET) can be applied to gain extra genetic yield through the production of embryos obtained from selected females and males (6).These programs in small ruminants are limited to the natural breeding season because small ruminants have seasonal cyclic activity patterns. In sheep, the breeding season lasts from August to November in temperate northern latitudes (7). Extending the application of these techniques outside of the breeding season would allow ewes involved in genetic improvement programs to undergo embryo recovery procedures throughout the year (8).However, conflicting results have been reported in studies designed to determine the effect of the season in MOET protocols. Some studies of superovulation application in ewes from high latitudes have reported seasonal differences in the rates of ovulation (9), fertilization, and embryo quality (8). Such differences are not present or are smaller in tropical and Mediterranean areas (10).

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“…Similar results were obtained in nuclear maturation rates: 67.75% in M1 and 73.18% in M2; however, the amplitude differences were statistically lower than those observed previously in cumulus cell expansion rates (p < 0.05). It has been shown that oocyte donor breed affects its developmental competence in other species (Ptak et al, 2003;Rátky et al, 2005). However, our results were within the average rates previously reported in other cattle breeds (Camargo et al, 1997;Kafi et al, 2002;Wang et al, 2007;McLaughlin & Telfer, 2010;Nicodemo et al, 2010).…”

supporting

confidence: 87%

Short communication: In vitro oocyte maturation and fertilization rates in the Spanish Lidia bovine breed

Demyda-Peyrás

Hidalgo

Dorado

et al. 2013

Span. j. agric. res.

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The Lidia bovine breed is the most successful cattle breed on the Iberian Peninsula, also considered a hallmark of Spanish tradition and image around the world. The aims of the study were to characterize the oocyte recovery rates and to evaluate the effect of two standard in vitro maturation protocols on oocyte maturation (cumulus expansion and nuclear maturation) and fertilization rates after in vitro fertilization in this breed. For this purpose, 261 ovaries from Lidia cows were processed obtaining 1,125 viable cumulus oocyte complexes (COCs). The oocyte recovery rate obtained (4.31 viable COCs per ovary) was lower than those described previously in other studied breeds. Maturation rates were evaluated in two different oocyte maturation media with (M1) and without (M2) hormonal supplementation. The percentage of COCs with expanded cumulus cells was significantly lower in M1 (74.35%) compared with M2 (82.25%). Metaphase II (MII) rates (67.75% in M1 and 73.18% in M2) were similar to previous studies in different cattle populations. M2 significantly improved the percentage of COCs with their cumulus cells expanded (p<0.01) and nuclear maturation rates (p<0.05), but it did not affect the fertilization percentages obtained in this experiment. In conclusion, our study suggests that oocytes of the Lidia cattle breed can be obtained, matured and fertilized following standard protocols previously used in other cattle breeds.

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Donor-Dependent Developmental Competence of Oocytes from Lambs Subjected to Repeated Hormonal Stimulation1

Cited by 37 publications

References 42 publications

Anti-Müllerian hormone as a predictive endocrine marker for embryo production in the goat

Anti-Müllerian hormone as a predictive endocrine marker for embryo production in the goat

Repeated superovulation treatments in Kivircik ewes during breeding and nonbreeding seasons

Short communication: In vitro oocyte maturation and fertilization rates in the Spanish Lidia bovine breed

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