Dopamine depletion increases the power and coherence of high-voltage spindles in the globus pallidus and motor cortex of freely moving rats

Ge, Shunnan; Yang, Chen; Li, Min; Li, Jiang; Chang, Xiaozan; Fu, Junjiang; Chen, Lei; Chang, Chongwang; Wang, Xuelian; Zhu, Jun-Ling; Gao, Guodong

doi:10.1016/j.brainres.2012.05.002

Cited by 19 publications

(18 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also notable was the intermittent presence of prominent high voltage spindles in the LFPs recorded during inattentive rest epochs, consisting of 3-5 sec epochs, when the LFP displayed prominent oscillations at frequencies of 5-13 Hz. This phenomenon has been described as being considerably more evident in the basal ganglia and motor cortex of the 6-OHDA-lesioned rat than in the control rat [32-34]. Interestingly, we noted that when a prominent high voltage spindle was present in the SNpr of the 6-OHDA lesioned hemisphere, a much smaller version, with shorter duration and lower amplitude could regularly be found occurring simultaneously in LFP recordings from the contralateral intact SNpr.…”

Section: Introductionsupporting

confidence: 49%

Oscillatory activity in basal ganglia and motor cortex in an awake behaving rodent model of Parkinson's disease

et al. 2014

View full text Add to dashboard Cite

Exaggerated beta range (15-30 Hz) oscillatory activity is observed in the basal ganglia of Parkinson's disease (PD) patients during implantation of deep brain stimulation electrodes. This activity has been hypothesized to contribute to motor dysfunction in PD patients. However, it remains unclear how these oscillations develop and how motor circuits become entrained into a state of increased synchronization in this frequency range after loss of dopamine. It is also unclear whether this increase in neuronal synchronization actually plays a significant role in inducing the motor symptoms of this disorder. The hemiparkinsonian rat has emerged as a useful model for investigating relationships between loss of dopamine, increases in oscillatory activity in motor circuits and behavioral state. Chronic recordings from these animals show exaggerated activity in the high beta/low gamma range (30-35 Hz) in the dopamine cell-lesioned hemisphere. This activity is not evident when the animals are in an inattentive rest state, but it can be stably induced and monitored in the motor cortex and basal ganglia when they are engaged in an on-going activity such as treadmill walking. This review discusses data obtained from this animal model and the implications and limitations of this data for obtaining further insight into the significance of beta range activity in PD.

show abstract

Section: Introductionsupporting

confidence: 49%

Oscillatory activity in basal ganglia and motor cortex in an awake behaving rodent model of Parkinson's disease

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Our present results in the rat model of Parkinson's disease cholinopathy are in accordance with evidence that dopamine depletion in 6-OHDA lesioned rats increase the density and duration of the high voltage spindles, as a particular pattern of spindle activity that also reflects the state of thalamo-cortical regulatory network [68].…”

Section: Transl Brainsupporting

confidence: 77%

“…In addition, there is increasing evidence in human [66,67] and animal studies [68,69] that abnormally synchronized oscillatory activity in the cortico-basal ganglia loop is associated with the motor deficits in Parkinson's disease, particularly beta synchronization (14-30 Hz) and high voltage spindles (5-13 Hz). Our present results in the rat model of Parkinson's disease cholinopathy are in accordance with evidence that dopamine depletion in 6-OHDA lesioned rats increase the density and duration of the high voltage spindles, as a particular pattern of spindle activity that also reflects the state of thalamo-cortical regulatory network [68].…”

Section: Transl Brainmentioning

confidence: 99%

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

Ciric¹,

Lazic²,

Petrović³

et al. 2017

Transl Brain Rhythmicity

View full text Add to dashboard Cite

Rhythmic oscillations of neuronal populations, generated by different mechanisms, are present at several levels of the central nervous system and serve many important physiological or reflect pathological functions. Understanding the role of brain oscillations as possible biomarkers of brain function and plasticity is still a challenge, and despite extensive research, their role is still not well established.We recently demonstrated that the hallmarks of earlier aging onset during impaired thalamo-cortical cholinergic innervation (in a rat model of Parkinson's disease cholinopathy) were consistently expressed, from 3 and one half to 5 and one half months of age, through increased electroencephalographic (EEG) sigma activity amplitude during rapid eye movement (REM) sleep, as a unique aging induced REM sleep phenomenon. In addition, there was altered motor cortical drive during non-rapid-eye-movement (NREM) and REM sleep.In order to explain this new aging-induced REM sleep phenomenon, we analyzed possible differences between control REM sleep spindle activity and REM sleep spindle activity at the onset of REM sleep "enriched" with sigma activity (at 4 and one half months of age), following bilateral pedunculopontine tegmental nucleus (PPT) cholinergic neuronal loss in the rat. We analzyed differences in spindle density, duration, and frequency.We demonstrated in young adult Wistar rats with the severely impaired PPT cholinergic innervation the alterations in sleep spindle dynamics and pattern during REM sleep in the motor cortex as the earliest biomarkers for the onset of their altered aging processes.

show abstract

“…Here, the PSD for each 30 s artifact-free segment was estimated using Welch's method, with a Hanning window of 1024 samples and an overlap of 512 data points for Fast Fourier Transform calculation. The relative PSD (rPSD) was defined as the ratio of PSD to total power in the 1–70 Hz frequency range [18].…”

Section: Methodsmentioning

confidence: 99%

“…In our recent study, we found that dopamine depletion significantly increased the power and coherence of HVSs in the globus pallidus (GP) and motor cortex of freely moving rats [18]. This indicates that dopamine plays a crucial role in the regulation of HVS activity throughout the cortical–BG circuit.…”

Section: Introductionmentioning

confidence: 91%

Systemic Blockade of Dopamine D2-Like Receptors Increases High-Voltage Spindles in the Globus Pallidus and Motor Cortex of Freely Moving Rats

Yang

Zhang

et al. 2013

PLoS ONE

Self Cite

View full text Add to dashboard Cite

High-voltage spindles (HVSs) have been reported to appear spontaneously and widely in the cortical–basal ganglia networks of rats. Our previous study showed that dopamine depletion can significantly increase the power and coherence of HVSs in the globus pallidus (GP) and motor cortex of freely moving rats. However, it is unclear whether dopamine regulates HVS activity by acting on dopamine D1-like receptors or D2-like receptors. We employed local-field potential and electrocorticogram methods to simultaneously record the oscillatory activities in the GP and primary motor cortex (M1) in freely moving rats following systemic administration of dopamine receptor antagonists or saline. The results showed that the dopamine D2-like receptor antagonists, raclopride and haloperidol, significantly increased the number and duration of HVSs, and the relative power associated with HVS activity in the GP and M1 cortex. Coherence values for HVS activity between the GP and M1 cortex area were also significantly increased by dopamine D2-like receptor antagonists. On the contrary, the selective dopamine D1-like receptor antagonist, SCH23390, had no significant effect on the number, duration, or relative power of HVSs, or HVS-related coherence between M1 and GP. In conclusion, dopamine D2-like receptors, but not D1-like receptors, were involved in HVS regulation. This supports the important role of dopamine D2-like receptors in the regulation of HVSs. An siRNA knock-down experiment on the striatum confirmed our conclusion.

show abstract

Dopamine depletion increases the power and coherence of high-voltage spindles in the globus pallidus and motor cortex of freely moving rats

Cited by 19 publications

References 66 publications

Oscillatory activity in basal ganglia and motor cortex in an awake behaving rodent model of Parkinson's disease

Oscillatory activity in basal ganglia and motor cortex in an awake behaving rodent model of Parkinson's disease

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

Systemic Blockade of Dopamine D2-Like Receptors Increases High-Voltage Spindles in the Globus Pallidus and Motor Cortex of Freely Moving Rats

Contact Info

Product

Resources

About