Dopamine transporter binding in depressed patients with anhedonia

Sarchiapone, Marco; Carli, Vladimir; Camardese, Giovanni; Cuomo, Chiara; Giuda, Daniela Di; Calcagni, Maria Lucia; Focacci, C; Risio, S. De

doi:10.1016/j.pscychresns.2006.03.001

Cited by 90 publications

(69 citation statements)

References 17 publications

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“…Current results support some earlier reports of decreased striatal DAT availability in major depression [20][21][22] and also confirm our previous finding of lower DAT levels in depressed patients with predominant anhedonic features [27] , even though patients with and without anhedonia did not differ from each other in 123 I-FP-CIT binding ratios.…”

Section: Discussionsupporting

confidence: 92%

“…Similarly, other authors reported higher DAT availability in depressed patients [24][25][26] . Currently, only one investigation has assessed DAT availability in major depressed subjects with predominant anhedonic symptoms: lower specific to nonspecific binding ratios were bilaterally found in the whole striatum as well as in the putamen and caudate of depressed anhedonic patients when compared to HC [27] .…”

Section: I-n-ω-fluoropropyl-carbomethoxy-3β-(4-iodophenyl)tropane Spementioning

confidence: 99%

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Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-ω-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Camardese¹,

Risio²,

Nicola³

et al. 2014

Neuropsychobiology

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Section: Discussionsupporting

confidence: 92%

Section: I-n-ω-fluoropropyl-carbomethoxy-3β-(4-iodophenyl)tropane Spementioning

confidence: 99%

Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-ω-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Camardese¹,

Risio²,

Nicola³

et al. 2014

Neuropsychobiology

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“…Dopamine neurons of the midbrain send projections to the amygdala, PFC, and NAc, and stress-induced changes in dopamine neurons in the ventral tegmental area (VTA) are linked to anhedonia and anxiety-like behavior in rodents [36, 49, 50, 54, 55]. In addition, anhedonia, a hallmark of MDD, is attributed, in part, to dysfunctional dopamine neurotransmission [56-61]. An overall reduction of dopamine neurotransmission within the mesocorticolimbic circuit has been described in patients with MDD and in multiple chronic stress paradigms in rodents.…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Effects of Stress on Mood-Related Gene Expression

et al. 2019

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Women are twice as likely as men to be diagnosed with major depressive disorder (MDD). Recent studies report distinct molecular changes in depressed men and women across mesocorticolimbic brain regions. However, it is unclear which sex-related factors drive distinct MDD-associated pathology. The goal of this study was to use mouse experimental systems to investigate sex-specific mechanisms underlying the distinct molecular profiles of MDD in men and women. We used unpredictable chronic mild stress to induce an elevated anxiety-/depressive-like state and “four core genotypes” (FCG) mice to probe for sex-specific mechanisms. As predicted, based on previous implications in mood, stress impacted the expression of several dopamine-, GABA-, and glutamate-related genes. Some of these effects, specifically in the prefrontal cortex, were genetic sex-specific, with effects in XX mice but not in XY mice. Stress also impacted gene expression differently across the mesocorticolimbic circuit, with increased expression of mood-related genes in the prefrontal cortex and nucleus accumbens, but decreased expression in basolateral amygdala. Our results suggest that females are sensitive to the effects of chronic stress, partly due to their genetic sex, independent of gonadal hormones. Furthermore, these results point to the prefrontal cortex as the node in the mesocorticolimbic circuitry with the strongest female-specific effects.

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“…Therefore, vulnerability to reinstate previously extinguished drug seeking may be associated with decreased DAT levels in the PFC and dSTR as observed in the current study. Decreases in DAT have also been observed in the dSTR of depressed patients displaying a lack of "normal" rewardmotivated behavior or anhedonia (Sarchiapone et al, 2006). It is interesting that anhedonia is also one of the symptoms typically associated with withdrawal from chronic Meth use (McGregor et al, 2005).…”

Section: Pfcmentioning

confidence: 99%

Extended Methamphetamine Self-Administration in Rats Results in a Selective Reduction of Dopamine Transporter Levels in the Prefrontal Cortex and Dorsal Striatum Not Accompanied by Marked Monoaminergic Depletion

Schwendt

Rocha²,

See³

et al. 2009

J Pharmacol Exp Ther

115

123

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Chronic abuse of methamphetamine leads to cognitive dysfunction and high rates of relapse, paralleled by significant changes of brain dopamine and serotonin neurotransmission. Previously, we found that rats with extended access to methamphetamine self-administration displayed enhanced methamphetamine-primed reinstatement of drug-seeking and cognitive deficits relative to limited access animals. The present study investigated whether extended access to methamphetamine self-administration produced abnormalities in dopamine and serotonin systems in rat forebrain. Rats self-administered methamphetamine (0.02-mg/i.v. infusion) during daily 1-h sessions for 7 to 10 days, followed by either short-(1-h) or longaccess (6-h) self-administration for 12 to 14 days. Lever responding was extinguished for 2 weeks before either reinstatement testing or rapid decapitation and tissue dissection. Tissue levels of monoamine transporters and markers of methamphetamine-induced toxicity were analyzed in several forebrain areas. Long-access methamphetamine self-administration resulted in escalation of daily drug intake (ϳ7 mg/kg/ day) and enhanced drug-primed reinstatement compared with the short-access group. Furthermore, long-, but not shortaccess to self-administered methamphetamine resulted in persistent decreases in dopamine transporter (DAT) protein levels in the prefrontal cortex and dorsal striatum. In contrast, only minor alterations in the tissue levels of dopamine or its metabolites were found, and no changes in markers specific for dopamine terminals or glial cell activation were detected. Our findings suggest that persistent methamphetamine seeking is associated with region-selective changes in DAT levels without accompanying monoaminergic neurotoxicity. Greater understanding of the neuroadaptations underlying persistent methamphetamine seeking and cognitive deficits could yield targets suitable for future therapeutic interventions.Methamphetamine (Meth) abuse in humans can quickly develop into a chronic relapsing disorder, accompanied by a wide range of neuropsychological deficits. For example, Meth addicts display impairments in memory functions, cognitive and psychomotor performance, as well as increased impulsivity and aggressive behavior (for reviews, see Nordahl et al., 2003;Scott et al., 2007). Human brain imaging studies provide evidence that these neuropsychological deficits are paralleled by significant changes in brain dopaminergic and serotonergic neurotransmitter systems, as well as altered general metabolic activity in basal ganglia and frontal cortices (for review, see Chang et al., 2007). In particular, chronic Meth abuse reduces the density of dopamine transporters (DAT) in the striatum and (to a lesser extent) in the frontal Article, publication date, and citation information can be found at

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Dopamine transporter binding in depressed patients with anhedonia

Cited by 90 publications

References 17 publications

Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-ω-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-ω-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Sex-Specific Effects of Stress on Mood-Related Gene Expression

Extended Methamphetamine Self-Administration in Rats Results in a Selective Reduction of Dopamine Transporter Levels in the Prefrontal Cortex and Dorsal Striatum Not Accompanied by Marked Monoaminergic Depletion

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Dopamine transporter binding in depressed patients with anhedonia

Cited by 90 publications

References 17 publications

Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-&#x03C9;-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-&#x03C9;-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Sex-Specific Effects of Stress on Mood-Related Gene Expression

Extended Methamphetamine Self-Administration in Rats Results in a Selective Reduction of Dopamine Transporter Levels in the Prefrontal Cortex and Dorsal Striatum Not Accompanied by Marked Monoaminergic Depletion

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Product

Resources

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Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-ω-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-ω-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study