Dose distribution of the brain tissue associated with cognitive functions in high-grade glioma patients

Jacob, J.; Clausse, E.; Benadjaoud, Mohamedamine; Jenny, C.; Ribeiro, Monica; Feuvret, L.; Mazeron, Jean‐Jacques; Antoni, D.; Bernier, Marie‐Odile; Hoang-Xuân, Khê; Psimaras, Dimitri; Ricard, Damien; Maingon, P.

doi:10.1016/j.canrad.2019.08.009

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…This atlas is available online and is now being used internationally by radiation oncologists (RTOs) and radiation therapy technologists (RTTs) in daily practice, as well as for research purposes [3][4][5][6]. Since this time, the search for organs at risk (OARs) associated with toxicity has continued [7,8]. Also new potential toxicities have been described, e.g.…”

Section: Discussionmentioning

confidence: 99%

Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology

Eekers

Perri

Roelofs

et al. 2021

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 99%

Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology

Eekers

Perri

Roelofs

et al. 2021

Radiotherapy and Oncology

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Late-onset vascular complications of radiotherapy for primary brain tumors: a case–control and cross-sectional analysis

et al. 2023

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Purpose Radiotherapy (RT) is a recognized risk factor for cerebrovascular (CV) disease in children and in adults with head and neck cancer. We aimed to investigate whether cerebral RT increases the risk of CV disease in adults with primary brain tumors (PBT). Methods We retrospectively identified adults with a supratentorial PBT diagnosed between 1975 and 2006 and with at least 10 years follow-up after treatment. We analyzed demographic, clinical, and radiological features with special attention to CV events. We also described CV events, vascular risk factors, and intracranial artery modifications in a cross-sectional study of irradiated patients alive at the time of the study. Results A total of 116 patients, treated with RT (exposed group), and 85 non-irradiated patients (unexposed group) were enrolled. Stroke was more frequent in irradiated PBT patients than in the unexposed group (42/116 (36%) vs 7/85 (8%); p < 0.001), with higher prevalence of both ischemic (27/116 (23%) vs 6/85 (7%); p = 0.004) and hemorrhagic (12/116 (10%) vs 1/85 (1%); p = 0.02) stroke. In the irradiated group, patients with tumors near the Willis Polygon were more likely to experience stroke (p < 0.016). Fourty-four alive irradiated patients were included in the cross-sectional study. In this subgroup, intracranial arterial stenosis was more prevalent (11/45, 24%) compared to general population (9%). Conclusions Stroke prevalence is increased in long-surviving PBT patients treated with cranial RT. Implications for cancer survivors CV events are frequent in long survivors of PBT treated with cerebral RT. We propose a check list to guide management of late CV complications in adults treated with RT for PBT.

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