Dose Ginger Have Preventative Effects on PONV-Related Eye Surgery? A Clinical Trial

Abstract

BackgroundPostoperative nausea and vomiting (PONV) is considered a common complication of anesthesia, which, particularly in eye surgery, may exert pressure on stitches and open or leak the surgical wound, leading to bleeding.ObjectivesWe aimed to study the effect of ginger on PONV and changes in vital signs after eye surgery.MethodsIn this triple-blind randomized controlled trial, 120 candidate patients for eye surgery were divided into group A (n = 40) and group B (n = 40). Patients in group A received the capsules of ginger 1 g while patients in group B received a placebo one hour before the procedure with 30 mL water. The incidence of nausea and the frequency of vomiting were evaluated at 0, 15, 30 minutes, and 2 hours after the operation. Also, the vital signs of the participants were recorded at certain times.ResultsThe results demonstrated a statistically significant difference in the frequency of nausea between group A and group B (P < 0.05). The severity of nausea was lower in group A than in group B immediately and 2 hours after recovery (P < 0.05). The incidence of vomiting was significantly lower in group A than in group B (P < 0.05). The vital signs were not significantly different between group A and group B (P > 0.05).ConclusionsGinger was effective in the prevention of PONV after eye surgery but had no impact on vital signs. Hence, ginger is proposed to use as a low-cost, prophylactic measure for PONV reduction.

Using Ginger Oil to Treat Nausea and Vomiting Following Breast Augmentation Surgery

“…In a meta-analysis pooling 918 patients undergoing laparoscopic, abdominal, and gynecological procedures, Tóth et al (2018) found that ginger significantly reduced the severity of PONV based on a VAS, a result that aligns with the findings of our study. In a triple-blind randomized-controlled trial, Sedigh Maroufi et al (2019) found ginger to be effective in preventing PONV in patients undergoing ocular surgery, further supporting the use of ginger in a variety of surgical operations.…”

Antioxidant Activity in Extracts from Zingiberaceae Family: Cardamom, Turmeric, and Ginger

“…showed that ginger or its bioactive compounds diminish acute and delayed phases of chemotherapy-induced nausea and vomiting nausea in breast cancer patients [ 84 ], producing inhibition of 5-hydroxytryptamine type3 (5-HT3) receptors in the central and peripheral nervous systems. The efficacy of ginger on postoperative nausea and vomiting [ 85 ] and on nausea and vomiting of pregnancy [ 86 ] has also been demonstrated.…”

Efficacy of Ginger in Preventing Postoperative Nausea and Vomiting: A Systematic Review and Meta‐Analysis

“…Figure S1 shows the detailed process of study selection. According to the Cochrane risk of bias assessing tool, only one study (Montazeri et al, 2013) was categorized as low risk of bias; five studies (Arfeen et al, 1995;Eberhart et al, 2003;Kamali et al, 2020;Naemi et al, 2020;Phillips et al, 1993) were categorized as unclear risk; and eight studies (Apariman et al, 2006;Bameshki et al, 2018;Bone et al, 1990;Maroufi et al, 2019;Nale et al, 2007;Nanthakomon & Pongrojpaw, 2006;Pongrojpaw & Chiamchanya, 2003;Visalyaputra et al, 1998) were categorized as high risk. The detailed risk of bias assessment is displayed in Figure S2.…”

“…Intervention groups of all included studies used capsules containing ginger. Nine studies compared the ginger and placebo groups (Apariman et al, 2006;Arfeen et al, 1995;Bameshki et al, 2018;Eberhart et al, 2003;Maroufi et al, 2019;Montazeri et al, 2013;Nale et al, 2007;Nanthakomon & Pongrojpaw, 2006;Pongrojpaw & Chiamchanya, 2003); four studies compared the ginger, antiemetic, and placebo groups (Bone et al, 1990;Kamali et al, 2020;Phillips et al, 1993;Visalyaputra et al, 1998); and only one study (Naemi et al, 2020) compared the ginger and antiemetic groups. In total, 12 studies gave a single dose of ginger while Nale et al (2007) and Eberhart et al (2003) gave multiple doses of ginger.…”

“…Time points of the outcome assessment ranged from entering recovery room to 48 h after surgery. Seven studies (Apariman et al, 2006;Arfeen et al, 1995;Bameshki et al, 2018;Maroufi et al, 2019;Montazeri et al, 2013;Nanthakomon & Pongrojpaw, 2006;Visalyaputra et al, 1998) reported nausea severity; 12 studies (Apariman et al, 2006;Arfeen et al, 1995;Bameshki et al, 2018;Bone et al, 1990;Eberhart et al, 2003;Maroufi et al, 2019;Montazeri et al, 2013;Nale et al, 2007;Nanthakomon & Pongrojpaw, 2006;Phillips et al, 1993;Pongrojpaw & Chiamchanya, 2003;Visalyaputra et al, 1998) reported the incidence of nausea and (or) vomiting; and seven studies reported the porprotion of rescue antimetic use (Arfeen et al, 1995;Bameshki et al, 2018;Bone et al, 1990;Eberhart et al, 2003;Nanthakomon & Pongrojpaw, 2006;Phillips et al, 1993;Pongrojpaw & Chiamchanya, 2003). Table S2 shows the detailed information of all included studies.…”