Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

Lijffijt, Marijn; Kenemans, J. Leon; Wal, Annemiek ter; Quik, Elise H.; Kemner, Chantal; Westenberg, H.G.M.; Verbaten, Marinus N.; Engeland, Hermán van

doi:10.1016/j.eurpsy.2005.04.003

Cited by 32 publications

(25 citation statements)

References 16 publications

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“…The performance of children with ADHD on Go/NoGo tasks is improved by MPH [9,10]. A similar effect can be achieved by teaching children the self-regulation strategy of implementation intentions [11,12], that is making 'if-then' plans, which facilitate the translation of task goals into effective goal-directed action, thereby helping these children to achieve better executive control [13].…”

Section: Introductionmentioning

confidence: 66%

If–then planning modulates the P300 in children with attention deficit hyperactivity disorder

Paul¹,

Gawrilow

Zech

et al. 2007

NeuroReport

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Children with attention de¢cit hyperactivity disorder have di⁄culties with tasks that require response inhibition.We measured electroencephalographic data of nonmedicated children with attention de¢cit hyperactivity disorder and control children in two conditions: (a) a neutral condition without a self-regulation strategy and (b) a condition that involved the making of if^then plans (i.e.'If situation X is encountered, then I will perform the goal-directed behaviorY'). If^then plans improved response inhibition and increased the P300 in children with attention de¢cit hyperactivity disorder compared with the neutral condition. The present results encourage the application of self-regulation using if^then plans in addition or as an alternative to common medical therapy. NeuroReport 18:653^657

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Section: Introductionmentioning

confidence: 66%

If–then planning modulates the P300 in children with attention deficit hyperactivity disorder

Paul¹,

Gawrilow

Zech

et al. 2007

NeuroReport

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“…Bedard et al 2003;Lijffijt et al 2006;Scheres et al 2003;Tannock et al 1989: for exceptions, see Aron et al 2003, where methylphenidate improved SSRT but not GoRT in adult ADHD and Overtoom et al 2003, where methylphenidate improved GoRT but not SSRT in childhood ADHD). As a treatment for deficits in SSRT task performance, methylphenidate appears to have a range of effects that are not specific to SSRT per se.…”

Section: The Effect Of Methylphenidate In Behavioural Controlmentioning

confidence: 94%

Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol

et al. 2007

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“…Modafinil is of particular interest to this review as its effects appear to be highly specific to action cancellation. Modafinil has no effects on either the go process (GoRT) or the no-delay, action-restraint component of the stopsignal task (Eagle et al 2007;Turner et al 2004), unlike conventional psychostimulants which often speed GoRT and SSRT (Bedard et al 2003;Lijffijt et al 2006;Tannock et al 1989). From a translational perspective, modafinil similarly improves SSRT in rats and humans (Eagle et al 2007;Turner 2006;Turner et al 2003Turner et al , 2004, effects that are directly comparable with the effects of conventional psychostimulants.…”

Section: Psychostimulant Effects On Action Inhibition: the Role Of Camentioning

confidence: 99%

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

2008

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Background and rationale The term 'action inhibition' encapsulates the ability to prevent any form of planned physical response. Growing evidence suggests that different 'stages' or even subtypes of action inhibition activate subtly different neuropharmacological and neuroanatomical processes. Objectives In this review, we present evidence from two commonly used and apparently similar behavioural tests, the stop-signal task and the go/no-go task, to determine if these have similar neuroanatomical and neurochemical modulation. Results Whilst performance of the stop-signal and go/no-go tasks is modulated across only subtly different anatomical networks, serotonin (5-HT) is strongly implicated in inhibitory control on the go/no-go but not the stop-signal task, whereas the stop-signal reaction time appears more sensitive to the action of noradrenaline. Conclusions There is clear neuropharmacological and neuroanatomical evidence that stop-signal and go/no-go tasks represent different forms of action inhibition. This evidence translates with remarkable consistency across species. We discuss the possible implications of this evidence with respect to the development of novel therapeutic treatments for disorders in which inhibitory deficits are prominent and debilitating.

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Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

Abstract: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

Cited by 32 publications

References 16 publications

If–then planning modulates the P300 in children with attention deficit hyperactivity disorder

If–then planning modulates the P300 in children with attention deficit hyperactivity disorder

Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

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