1999
DOI: 10.1136/bjo.83.10.1121
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Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome

Abstract: Double blind, randomised, placebo controlled, crossover, multicentre study to determine the eYcacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) Abstract Background/aims-Hyaluronan (sodium hyaluronate) has been shown to confer objective and subjective improvement in patients with dry eye syndrome. This study compared the eYcacy and safety of a 0.1% solution of hyaluronan with 0.9% saline, when administered topically to the eye, in the treatment of symptoms of severe dry eye syndrome. Methods-A rand… Show more

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Cited by 70 publications
(65 citation statements)
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“…Sodium hyaluronate increases tear film stability by increasing tear film viscosity between blinks [2]. Clinical trials of sodium hyaluronate dry eye treatment have reported an increase in ocular comfort [1][2][3][4]15], a reduction in NaFl corneal staining [3], a reduction in Rose Bengal staining [28], an increase in NITBUT [2,4], an increase in Schirmer's score [29] and an improvement in impression cytology grading [16]. Sodium hyaluronate is a naturally occurring glycosaminoglycan of the extracellular matrix and a ligand for the hyaluronate receptor CD44 [30].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Sodium hyaluronate increases tear film stability by increasing tear film viscosity between blinks [2]. Clinical trials of sodium hyaluronate dry eye treatment have reported an increase in ocular comfort [1][2][3][4]15], a reduction in NaFl corneal staining [3], a reduction in Rose Bengal staining [28], an increase in NITBUT [2,4], an increase in Schirmer's score [29] and an improvement in impression cytology grading [16]. Sodium hyaluronate is a naturally occurring glycosaminoglycan of the extracellular matrix and a ligand for the hyaluronate receptor CD44 [30].…”
Section: Discussionmentioning
confidence: 99%
“…Activation of CD44 promotes the interaction with cytoskeletal proteins, facilitating cellular migration [5,6,31,32]. CD44 is over-expressed within conjunctival and corneal cells of patients with dry eye [13] and corneal inflammation [29]. Sodium hyaluronate has a high affinity for CD44 receptors and tri-daily application of sodium hyaluronate for 2 months has been shown to significantly reduce the expression of CD44 [15].…”
Section: Discussionmentioning
confidence: 99%
“…Esse mesmo pensamento clínico pode ser usado no que diz res peito a comparação entre os dois colírios estudados. Estatisticamente não houve diferença significativa da mesma forma que outros relatos, os quais afirmam que apesar das propriedades mucoadesivas mais eficientes do HS, este não torna a reepitelização mais rápida (6,16) . Quando foi comparado o resultado de reepitelização a cada dia, ob servouse diferença significativa a partir de 96 horas.…”
Section: Discussionunclassified
“…Em estudo randomizado, duplo-cego cruzado, Condon et al, compararam eficácia e segurança da solução de NaAH 0,1% com a solução salina 0,9% em pacientes com olho seco grave. Concluíram que a primeira solução tem vantagens tanto na diminuição dos sintomas quanto no aspecto da superfície ocular ao exame oftalmológico (15) . Aragona et al, estudaram os efeitos do tratamento de olho seco com soluções hipotônica e isotônica de NaAH 0,4%.…”
Section: Desordens Da Superfície Ocularunclassified