Double functionalization of chitosan based nanofibers towards biomaterials for wound healing

Lungu, Ramona; Anisiei, Alexandru; Roșca, Irina; Sandu, Andreea-Isabela; Ailincai, Daniela; Marin, Luminița

doi:10.1016/j.reactfunctpolym.2021.105028

Cited by 25 publications

(18 citation statements)

References 40 publications

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“…The in vitro degradation of the Gel-TA hydrogels was evaluated in PBS solution containing 1 mg/ml lysozyme as a degradation media, which was refreshed with new media once per three days (Lungu et al, 2021). The specific weight of the dried hydrogels was immersed into a degradation medium and then incubated in an oven with a temperature of 37℃.…”

Section: Physiochemical Characterizationmentioning

confidence: 99%

Tannic acid post-treatment of enzymatically crosslinked chitosan-alginate hydrogels for biomedical applications

Jafari

Ghaffari-Bohlouli

Podstawczyk

et al. 2022

Carbohydrate Polymers

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Section: Physiochemical Characterizationmentioning

confidence: 99%

Tannic acid post-treatment of enzymatically crosslinked chitosan-alginate hydrogels for biomedical applications

Jafari

Ghaffari-Bohlouli

Podstawczyk

et al. 2022

Carbohydrate Polymers

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“…For GTR membranes, structural and mechanical integrity is expected for four to six weeks [ 40 , 41 ]. We evaluated the enzyme-catalyzed hydrolysis of the CoPEC membranes in a lysozyme solution, as this enzyme cleaves the 1,4-beta-linkages between N-acetyl-D-glucosamine residues of chitosan [ 42 ]. Figure 6 b shows the weight loss of the produced membranes after 31 days.…”

Section: Resultsmentioning

confidence: 99%

Exploiting Polyelectrolyte Complexation for the Development of Adhesive and Bioactive Membranes Envisaging Guided Tissue Regeneration

Fonseca

Vale

Costa

et al. 2022

JFB

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Mussels secrete protein-based byssal threads to tether to rocks, ships, and other organisms underwater. The secreted marine mussel adhesive proteins (MAPs) contain the peculiar amino acid L-3,4-dihydroxyphenylalanine (DOPA), whose catechol group content contributes greatly to their outstanding adhesive properties. Inspired by such mussel bioadhesion, we demonstrate that catechol-modified polysaccharides can be used to obtain adhesive membranes using the compaction of polyelectrolyte complexes (CoPEC) method. It is a simple and versatile approach that uses polyelectrolyte complexes as building blocks that coalesce and dry as membrane constructs simply as a result of sedimentation and mild temperature. We used two natural and biocompatible polymers: chitosan (CHI) as a polycation and hyaluronic acid (HA) as a polyanion. The CoPEC technique also allowed the entrapment of ternary bioactive glass nanoparticles to stimulate mineralization. Moreover, combinations of these polymers modified with catechol groups were made to enhance the adhesive properties of the assembled membranes. Extensive physico-chemical characterization was performed to investigate the successful production of composite CoPEC membranes in terms of surface morphology, wettability, stability, mechanical performance, in vitro bioactivity, and cellular behavior. Considering the promising properties exhibited by the obtained membranes, new adhesives suitable for the regeneration of hard tissues can be envisaged.

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“…Their ratio evolved over the hydrogelation period, according to an imination degree of 18.9% in the first few minutes, to 26.1% after one hour. On the other hand, the FTIR spectrum on the corresponding lyophilized hydrogel showed the occurrence of the absorption band characteristic for the imine linkage at 1628 cm −1 [18][19][20][21][22] and no band specific for the aldehyde group [22][23][24], proving that the imination equilibrium was shifted to the products during the water removal process (Figure 3). This confirmed that the imination was a reversible process, which could be modified under the influence of external stimuli.…”

Section: Structural and Supramolecular Characterizationmentioning

confidence: 99%

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings

Lungu

Paun

Peptanariu

et al. 2022

Gels

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Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific practices. In this conceptual framework, the present paper deals with the investigation of a hydrogel as bioabsorbable wound dressing. To this aim, chitosan was cross-linked with 2-formylphenylboronic acid to yield a hydrogel with antimicrobial activity. FTIR, NMR, and POM procedures have characterized the hydrogel from a structural and supramolecular point of view. At the same time, its biocompatibility and antimicrobial properties were also determined in vitro. Furthermore, in order to assess the bioabsorbable character, its biodegradation was investigated in vitro in the presence of lysosome in media of different pH, mimicking the wound exudate at different stages of healing. The biodegradation was monitored by gravimetrical measurements, SEM microscopy and fractal analyses of the images. The fractal dimension values and the lacunarity of SEM pictures were accurately calculated. All these successful investigations led to the conclusion that the tested materials are at the expected high standards.

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Double functionalization of chitosan based nanofibers towards biomaterials for wound healing

Cited by 25 publications

References 40 publications

Tannic acid post-treatment of enzymatically crosslinked chitosan-alginate hydrogels for biomedical applications

Tannic acid post-treatment of enzymatically crosslinked chitosan-alginate hydrogels for biomedical applications

Exploiting Polyelectrolyte Complexation for the Development of Adhesive and Bioactive Membranes Envisaging Guided Tissue Regeneration

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings

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