Down expression of lnc-BMP1-1 decreases that of Caveolin-1 is associated with the lung cancer susceptibility and cigarette smoking history

Abstract

Lnc-BMP1-1 is a lncRNA transcribed from SFTPC (surfactant associated protein C), a lung tissue specific gene encoding pulmonary-associated surfactant protein C (SPC) that is solely secreted by alveolar typeⅡ epithelial cells, among which the ones with SFTPC+ might be transformed into lung adenocarcinoma cells. Caveolin-1 (Cav-1) is a candidate tumor suppressor gene and is vital for coping with oxidative stress induced by cigarette smoke. When comparing lung cancer tissues with their adjacent normal tissues, the expression of lnc-BMP1-1 were decreased, especially in patients with cigarette smoking history (P=0.027), and positively associated with the expression of Cav-1 (P<0.001). When comparing to A549 cells transfected with empty vector (A549-NC cells), the expression level of Cav-1 in A549 cells with overexpressed lnc-BMP1-1 (A549-BMP cells) was increased along with the decreased level of HDAC2 protein. The drug sensitivity of A549-BMP cells to Doxorubicin hydrochloride (DOX) was increased; the growth and migration capability of A549-BMP cells were inhibited along with the decreased protein level of Bcl-2 and DNMT3a; the growth of tumor in nude mice injected with A549-BMP cells were inhibited, too. Furthermore, the lnc-BMP1-1 and Cav-1 expression was also down-regulated in the human bronchial epithelial (16HBE) cells treated with cigarette smoke extract (CSE).

Plasma exosomal caveolin-1 predicts Poor Prognosis in Ovarian Cancer

“…CAV1 has also been confirmed to be expressed in lymphocytes and plays a potential role in latent HIV infection [21]. In recent years, the role of CAV1, as a candidate tumor suppressor gene, has attracted increased attention [22,23]. Many studies have shown that CAV1 is expressed in almost all normal cells, but the expression of CAV1 in most cancer cells or cells transformed by oncogenes is significantly reduced [24].…”

The Structural Proteins of Membrane Rafts, Caveolins and Flotillins, in Lung Cancer: More Than Just Scaffold Elements

“…This gene is transcribed from the intron area of surfactant protein C; thus, highly expressed in the lung. Recent studies show that Lnc-BMP1-1 might promote the transcription of CAV1 by downregulating the expression of histone deacetylase 2 106 (figure 3 A). Lnc-BMP1-1 expression was decreased in LC tissues, especially in patients with a history of cigarette smoking; therefore, it is logical to expect a lower expression of CAV1 in those patients.…”

The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier

“…It was first found in bones and has been reported to play a variety of functions in bone formation [63]. Some studies have also found that this may be related to susceptibility to lung cancer [64]. Presently, some studies have found that the expression of its transcriptional product lncRNABmp1 is significantly increased in a burn mouse model, and the Bmp1 content is upregulated after intestinal mucosal injury.…”