Down regulation of lincRNA-p21 contributes to gastric cancer development through Hippo-independent activation of YAP

Chen, Ying; Wei, Guoqing; Xiao, Hong‐Wei; Yu, Huangfei; Tang, Qiuling; Bi, Feng

doi:10.18632/oncotarget.19130

Cited by 28 publications

(22 citation statements)

References 37 publications

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“…72 Consistently, its depletion in gastric cancer promotes EMT phenotypic changes in cells, and these changes are also seen at the transcriptome level. 73 79 Likewise, the overexpression of PVT1 resulted in an increase of Snail and ZEB1 expression in pancreatic cancer (Figure 2). 80…”

Section: Tumor Driversmentioning

confidence: 88%

Emerging roles of long non‐coding RNA in cancer

Calle¹,

Kawamura

Yamamoto³

et al. 2018

Cancer Science

529

407

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Since comprehensive analysis of the mammalian genome revealed that the majority of genomic products are transcribed in long non‐coding RNA (lncRNA), increasing attention has been paid to these transcripts. The applied next‐generation sequencing technologies have provided accumulating evidence of dysregulated lncRNA in cancer. The implication of this finding can be seen in many forms and at multiple levels. With impacts ranging from integrating chromatin remodeling complexes to regulating transcription and post‐transcriptional processes, aberrant expression of lncRNA may have repercussions in cell proliferation, tumor progression or metastasis. lncRNA may act as enhancers, scaffolds or decoys by physically interacting with other RNA species or proteins, resulting in a direct impact on cell signaling cascades. Even though their functional classification is well‐established in the context of cancer, clearer characterization in terms of their phenotypic outputs is needed to optimize and identify suitable candidates that enable the development of new therapeutic strategies and the design of novel diagnostic approaches. The present article aims to outline different cancer‐associated lncRNA according to their contribution to tumor suppression or tumor promotion based on their most current functional annotations.

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Section: Tumor Driversmentioning

confidence: 88%

Emerging roles of long non‐coding RNA in cancer

Calle¹,

Kawamura

Yamamoto³

et al. 2018

Cancer Science

529

407

View full text Add to dashboard Cite

show abstract

“…Some research have reported LncRNAs had involvement in the adjustment of EMT process of several cancer types. For example, knockdown of lincRNA-p21 promoted EMT of gastric cancer cells, but overexpression of lincRNA-p21 exerted opposite effects [29]. LincHOTAIR indirectly inhibited miR-7 to reverse the EMT process of breast cancer stem cells [30].…”

Section: Discussionmentioning

confidence: 99%

Up-regulated Linc00472 suppresses development of lung cancer cell via inhibition of MiR-196b-5p

Mao¹,

Zhou²,

Li³

et al. 2019

Bioscience, Biotechnology, and Biochemistry

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The role of linc00472 in lung cancer (LC) has been rarely reported. We aimed to study the role of linc00472 in LC progression. Expressions of linc00472 and miR-196b-5p in LC cell lines were measured by qRT-PCR. The targeting relationship between linc00472 and miR-196b-5p was determined by Starbase and dual-luciferase reporter. The viability, migration, invasion, and apoptosis of LC cells were determined using CCK-8 assay, scratch test, transwell assay, and flow cytometry, respectively. The levels of epithelial-to-mesenchymal transition (EMT)-related proteins and apoptosis-related proteins in LC cells were determined by western blot. Downregulated linc00472 was observed in five LC cell lines. Linc00472 overexpression suppressed viability, migration, invasion and EMT process, but elevated apoptotic rate in LC cells. MiR-196b-5p mimic promoted viability, migration, invasion, and EMT process, but decreased apoptotic rate, which was reversed by up-regulated linc00472. Linc00472 functioned as a cancer suppressor via negatively regulating miR-196b-5p of LC cells.

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“…With regard to the function of MALAT1 in specific cells, the present study hypothesized that an interaction between MALAT1 and p53 exists in colorectal neoplasms. Previous studies have assessed the expression of lincRNA-p21 with various types of cancer (18,35,36). However, few studies report the influence of lincRNa-p21 on CRC.…”

Section: Lncrna-rormentioning

confidence: 99%

Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

et al. 2020

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Colorectal cancer (CRC) is a common intestinal cancer with a high mortality rate. Early detection of this type of cancer is fundamental to the prevention of the disease, which results in improved survival rates. In the human colon tissue, transition from normal epithelium to adenoma is considered to be caused by unknown molecular incidents occurring over 5-10 years. The detection of CRC has proved problematic when in the early stages of disease. In addition, identifying suitable biomarkers for the detection of CRC progress in patients remains one of the most significant challenges. Long non-coding RNAs have been demonstrated to contribute to the promotion of CRC. The aim of the present study was to investigate the clinical and biological significance of long intergenic non-coding (linc)RNA-p21, lincRNA-regulator of reprogramming (ROR) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the colon tumor and polyp tissue, and the association that these have with the expression of p53 at the mRNA level. Neoplastic and paired adjacent normal tissue samples were obtained from 72 patients (46 polyps and 26 tumors). Reverse transcription-quantitative PCR was performed to determine the relative fold changes in the expression of lincRNA-p21, lincRNA-RoR, MALAT1 and p53 in the samples. A significant association was observed between the levels of MALAT1 and p53 in neoplasm tissues (R=0.073; P<0.05). The relative expression of the MALAT1 gene revealed a statistically significant difference between the different polyp types and number of polyps (P=0.0028 and 0.022, respectively). Adjuvant therapy in patients with tumors revealed an association between the levels of lincRNA-ROR and lincRNA-p21 expression (P=0.015 and 0.038, respectively). MALAT1 may be selected as an early detection biomarker for CRC. Furthermore, lincRNA-ROR and lincRNA-p21 may serve as prognostic and therapeutic biomarkers in patients with CRC.

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Down regulation of lincRNA-p21 contributes to gastric cancer development through Hippo-independent activation of YAP

Cited by 28 publications

References 37 publications

Emerging roles of long non‐coding RNA in cancer

Emerging roles of long non‐coding RNA in cancer

Up-regulated Linc00472 suppresses development of lung cancer cell via inhibition of MiR-196b-5p

Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

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