Down-regulation of MLLT1 super elongation complex subunit impairs the anti-tumor activity of natural killer cells in esophageal cancer

Liu, Chong; Li, Xueman; Xiong, Fei; Wang, Lingying; Chen, Kang; Wu, Ping-Shang; Hua, Li; Zhang, Zhuo

doi:10.1016/j.imbio.2022.152238

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…SUPT5H was positively correlated with activated memory CD4 + T cells [ 67 ]. MLLT1 is down-regulated in NK cells expressing T cell immunoglobulin [ 68 ]. These TFs had been studied in kinds of diseases, particularly in cancer, but the role of these genes in advanced age COVID-19 patients need further study.…”

Section: Discussionmentioning

confidence: 99%

Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients

Yao

Chen

et al. 2023

BMC Med Genomics

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The risk of severe condition caused by Corona Virus Disease 2019 (COVID-19) increases with age. However, the underlying mechanisms have not been clearly understood. The dataset GSE157103 was used to perform weighted gene co-expression network analysis on 100 COVID-19 patients in our analysis. Through weighted gene co-expression network analysis, we identified a key module which was significantly related with age. This age-related module could predict Intensive Care Unit status and mechanical-ventilation usage, and enriched with positive regulation of T cell receptor signaling pathway biological progress. Moreover, 10 hub genes were identified as crucial gene of the age-related module. Protein–protein interaction network and transcription factors-gene interactions were established. Lastly, independent data sets and RT-qPCR were used to validate the key module and hub genes. Our conclusion revealed that key genes were associated with the age-related phenotypes in COVID-19 patients, and it would be beneficial for clinical doctors to develop reasonable therapeutic strategies in elderly COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients

Yao

Chen

et al. 2023

BMC Med Genomics

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“…Therefore, a reasonable speculation is that TMEM147 promotes tumor progression possibly by affecting protein biosynthesis in HCC. CTCF, MLLT1, and TGIF2 are transcriptional regulators that play crucial roles in the transcription of important proto-oncogenes such as FOXM1, MYC, HoxA gene family, and OCT4 in multiple cancer types including HCC, esophageal cancer, and lung adenocarcinoma ( Zhang et al, 2017 ; Du et al, 2019 ; Liu et al, 2022 ). ZNF146 and ZNF580 are both members of the C2H2 family of Zinc finger proteins.…”

Section: Discussionmentioning

confidence: 99%

TMEM147 is a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma

et al. 2023

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Hepatocellular carcinoma (HCC) is the most common type of liver malignancy with high incidence and poor prognosis. Transmembrane protein 147 (TMEM147) has been implicated in the development of colon cancer. However, the role of TMEM147 in HCC remains unclear. In this study, data of 371 HCC tissues, 50 adjacent nontumor tissues, and 110 normal liver tissues were retrieved from the TCGA and GTEx databases. TMEM147 expression was found to be increased in HCC tissues. High expression of TMEM147 was related to poor prognosis, and TMEM147 was confirmed to be an independent prognostic factor for HCC patients. A receiver operating characteristics (ROC) analysis was performed and showed that the diagnostic efficacy of TMEM147 was significantly higher than that of AFP (0.908 versus 0.746, p < 0.001). Furthermore, TMEM147 promoted tumor immune infiltration, and macrophages were the immune cells that predominantly expressed TMEM147 in HCC. Further analysis revealed that TMEM147 mainly impacted the ribosome pathway, and CTCF, MLLT1, TGIF2, ZNF146, and ZNF580 were predicted to be the upstream transcription factors for TMEM147 in HCC. These results suggest that TMEM147 serves as a promising biomarker for diagnosis and prognosis and may potentially become a therapeutic target for HCC.

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“…The isolation and culture method of murine CD8+ T cells and NK cells are based on earlier reported methods. 58,59 The cytotoxicity, cellular internalization, and transfection efficiency of UIP were evaluated on the basis of previously reported works. 44,48 The cytotoxicity of IUIPC in CD8+ T cells and NK cells was evaluated using the trypan blue dye exclusion assay reported earlier.…”

Section: Methodsmentioning

confidence: 99%

“…The murine hepatoma cell line Hepa1-6 and the mouse embryonic fibroblast cell line NIH 3T3 were employed in the current study. The isolation and culture method of murine CD8+ T cells and NK cells are based on earlier reported methods. , The cytotoxicity, cellular internalization, and transfection efficiency of UIP were evaluated on the basis of previously reported works. , The cytotoxicity of IUIPC in CD8+ T cells and NK cells was evaluated using the trypan blue dye exclusion assay reported earlier . Western blot assay and ELISA assay were employed to verify the UIP-mediated CXCL9 cDNA expression .…”

Section: Methodsmentioning

confidence: 99%

Janus Silica Nanoparticle-Based Tumor Microenvironment Modulator for Restoring Tumor Sensitivity to Programmed Cell Death Ligand 1 Immune Checkpoint Blockade Therapy

Lin

Guan

et al. 2023

ACS Nano

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An immunosuppressive tumor microenvironment (TME) with inadequate and exhausted tumor-infiltrating cytotoxic lymphocytes and abundant cellular immunosuppressors is the major obstacle responsible for the poor efficacy of PD-1/PD-L1 (programmed cell death 1 and its ligand 1) immune checkpoint blockade (ICB) therapy. Herein, a Janus silica nanoparticle (JSNP)-based immunomodulator is explored to reshape the TME for boosting the therapeutic outcomes of αPD-L1 therapy. The designed JSNP has two distinct domains, namely, an ultra pH-responsive side (UPS), which could encapsulate PI3Kγ inhibitor IPI549 in the pore structure, and a polycation-grafted intra-glutathione (GSH)-sensitive side (IGS), which could absorb CXCL9 cDNA on the surface. The final IPI549@UPS-IGS-PDMAEMA@CXCL9 cDNA (IUIPC) could release IPI549 in weak acid TME to target myeloid-derived suppressor cells (MDSCs) to reverse negative immunoregulation and then release CXCL9 cDNA in tumor cells with abundant GSH for sustained CXCL9 chemokine expression and secretion to improve cytotoxic lymphocyte recruitment signals, thereby jointly restoring tumor sensitivity to PD-1/PD-L1 ICB therapy. As expected, the IUIPC-mediated TME remodeling during αPD-L1 therapy significantly ameliorated TME immunosuppression, as well as induced potent systemic antitumor immune responses, which ultimately achieved a robustly boosted antitumor efficacy proven by remarkable suppression of primary tumor growth, obvious prevention of tumor recurrence, and significant regression of abscopal tumors. Hence, the IUIPC-mediated TME-regulating strategy provides an enormous perspective for the improvement of PD-1/PD-L1 ICB therapy.

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Down-regulation of MLLT1 super elongation complex subunit impairs the anti-tumor activity of natural killer cells in esophageal cancer

Cited by 4 publications

References 29 publications

Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients

Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients

TMEM147 is a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma

Janus Silica Nanoparticle-Based Tumor Microenvironment Modulator for Restoring Tumor Sensitivity to Programmed Cell Death Ligand 1 Immune Checkpoint Blockade Therapy

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