Doxorubicin-induced cardiotoxicity in mice; protection by silymarin

Aniss, Heba Abdelnasser; AdLy, Camelia; Said, Azza Mohamed Ahmed; Sayed, Ibrahim H. El

doi:10.21608/ejhm.2012.16242

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the fight against DOX-induced cardiotoxicity, people are turning to natural products as a defense approach (11). Antioxidant compounds may help protect cells and tissues from the detrimental effects of free radicals caused by DOX (12). Incorporating vitamin E, which has antioxidant properties, may reduce DOX's damaging effect on cardiomyocytes without interfering with its ability to target cancer cells (13,14).…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Induced Cardiotoxicity in Adult Male Albino Rats and the Ameliorative Effects of Achillea Fragrantissima Crude Extract, Its Combined Ethyl Acetate/n. Butanol Fraction, and Vitamin E

Ameen

Mostafa

Eltamany

et al. 2023

BESPS

View full text Add to dashboard Cite

Doxorubicin (DOX) is a potent chemotherapeutic agent. Unfortunately, due to the incidence of dose-dependent cardiotoxicity, its clinical usage is hampered. Natural products are gaining popularity as a means of preventing DOX-induced cardiotoxicity. In the present study, we investigated the cardiotoxic effects of DOX and assessed the potential ameliorative effects of Achillea fragrantissima extract, its combined ethyl acetate/ n. butanol (EtOAc-Bu) fraction, and vitamin E in adult male albino rats. Rats were randomly divided into five groups: Control, DOX, DOX + A. fragrantissima crude extract, DOX + its (EtOAc-Bu) fraction, DOX + Vitamin E. A single dose of DOX (15 mg/kg) was given intraperitoneally (ip) in each group except the control.Rats were assessed before scarification for arterial blood pressure and ECG recordings. Serum and heart tissue were collected for biochemical, and histopathological assessment. Pre-treatment with vitamin E, 0A. fragrantissima crude extract, and its (EtOAc-Bu) fraction ameliorated DOXinduced cardiotoxicity, in varying degrees and with varying significance, as evidenced by reversing the DOX-induced ECG changes, reducing serum cardiac enzymes, and improving DOX-induced histopathological changes. All the suggested protective measures, in varying degrees and with varying significance, reduced the oxidative stress, lipid peroxidation, and apoptosis markers (reduced NO, and MDA, down-regulated mRNA expression of both iNOS and caspase-3), and elevated the antioxidants markers (GR, SOD, and TAC). We concluded that such suggested natural products might offer a promising chemo-preventive approach against cardiotoxicity induced by DOX.

show abstract

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Induced Cardiotoxicity in Adult Male Albino Rats and the Ameliorative Effects of Achillea Fragrantissima Crude Extract, Its Combined Ethyl Acetate/n. Butanol Fraction, and Vitamin E

Ameen

Mostafa

Eltamany

et al. 2023

BESPS

View full text Add to dashboard Cite

show abstract

Effects of combined administration of doxorubicin and chloroquine on lung pathology in mice with solid Ehrlich ascites carcinoma

Utkusavaş

Gürevin

Yilmazer

et al. 2022

Biotechnic & Histochemistry

View full text Add to dashboard Cite

Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Abdel‐Moneim

Alzahrani

Ali

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Acrylamide (AA) is a well-known potent carcinogen and neurotoxin that has been recently linked to atherosclerotic pathogenesis. The present study is aimed at investigating the protective effect of silymarin (SIL) as an antioxidant against AA-induced hyperlipidemic cardiomyopathy in male rats. The obtained results showed that animals exposed to AA exhibited a significant increase in the levels of cardiac serum markers, serum total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol with a significant decrease in high-density lipoprotein cholesterol. Furthermore, AA intoxication significantly increased the malondialdehyde level (a hallmark of lipid peroxidation) and reduced antioxidant enzyme activities (i.e., superoxide dismutase, catalase, and glutathione peroxidase). SIL administration significantly attenuated all these biochemical perturbations in AA-treated rats, except for the decreased high-density lipoprotein cholesterol. Our results were confirmed by histopathological assessment of the myocardium. In conclusion, this study demonstrated a beneficial effect of SIL therapy in the prevention of AA-induced cardiotoxicity by reversing the redox stress and dyslipidemia in experimental animals.

show abstract

Doxorubicin-induced cardiotoxicity in mice; protection by silymarin

Cited by 3 publications

References 0 publications

Doxorubicin-Induced Cardiotoxicity in Adult Male Albino Rats and the Ameliorative Effects of Achillea Fragrantissima Crude Extract, Its Combined Ethyl Acetate/n. Butanol Fraction, and Vitamin E

Doxorubicin-Induced Cardiotoxicity in Adult Male Albino Rats and the Ameliorative Effects of Achillea Fragrantissima Crude Extract, Its Combined Ethyl Acetate/n. Butanol Fraction, and Vitamin E

Effects of combined administration of doxorubicin and chloroquine on lung pathology in mice with solid Ehrlich ascites carcinoma

Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Contact Info

Product

Resources

About