DRO1/CCDC80: a Novel Tumor Suppressor of Colorectal Carcinogenesis

Grill, Jessica I.; Kolligs, Frank T.

doi:10.1007/s11888-015-0276-3

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…Ras Association Domain Family Member 1 (RASSF1C) located on chromosome 3, which interacts with Bax, Caspase 3, and SRPX gene could promote cell migration and downregulate apoptosis. 137 The BRCA2 gene associated with TREX-2 complex subunit PCID and DSS1 that are implicated in messenger ribonucleoprotein (mRNP) biogenesis and export and maintenance of the genome stability. 138 These associations use to indicate that R-loop is the major cause of replication-related stress and cellular instability.…”

Section: Chromosome-autosome Crosstalkmentioning

confidence: 99%

“…X‐linked TSGs, directly and indirectly, interact with sex chromosomes and autosomes through genetic, physical, and biological interactions, resulting, which can lead to various types of diseases, including cancer. Ras Association Domain Family Member 1 ( RASSF1C ) located on chromosome 3, which interacts with Bax, Caspase 3, and SRPX gene could promote cell migration and downregulate apoptosis 137 . The BRCA2 gene associated with TREX‐2 complex subunit PCID and DSS1 that are implicated in messenger ribonucleoprotein (mRNP) biogenesis and export and maintenance of the genome stability 138 .…”

Section: Chromosome–autosome Crosstalkmentioning

confidence: 99%

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Oncogenes and tumor suppressor genes: functions and roles in cancers

Dakal,

Dhabhai,

Pant

et al. 2024

MedComm

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Cancer, being the most formidable ailment, has had a profound impact on the human health. The disease is primarily associated with genetic mutations that impact oncogenes and tumor suppressor genes (TSGs). Recently, growing evidence have shown that X‐linked TSGs have specific role in cancer progression and metastasis as well. Interestingly, our genome harbors around substantial portion of genes that function as tumor suppressors, and the X chromosome alone harbors a considerable number of TSGs. The scenario becomes even more compelling as X‐linked TSGs are adaptive to key epigenetic processes such as X chromosome inactivation. Therefore, delineating the new paradigm related to X‐linked TSGs, for instance, their crosstalk with autosome and involvement in cancer initiation, progression, and metastasis becomes utmost importance. Considering this, herein, we present a comprehensive discussion of X‐linked TSG dysregulation in various cancers as a consequence of genetic variations and epigenetic alterations. In addition, the dynamic role of X‐linked TSGs in sex chromosome–autosome crosstalk in cancer genome remodeling is being explored thoroughly. Besides, the functional roles of ncRNAs, role of X‐linked TSG in immunomodulation and in gender‐based cancer disparities has also been highlighted. Overall, the focal idea of the present article is to recapitulate the findings on X‐linked TSG regulation in the cancer landscape and to redefine their role toward improving cancer treatment strategies.

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Section: Chromosome-autosome Crosstalkmentioning

confidence: 99%

Section: Chromosome–autosome Crosstalkmentioning

confidence: 99%

Oncogenes and tumor suppressor genes: functions and roles in cancers

Dakal,

Dhabhai,

Pant

et al. 2024

MedComm

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“…In colon tumors from Apc Min/+ mice loss of DRO1/CCDC80 induces ERK1/2 phosphorylation and leads to c-MYC oncogene activation [ 1 ]. The Dro1/Ccdc80 tumor suppressor function has been reviewed in detail in [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis

et al. 2022

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Tumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk which plays an integral part in tumor initiation, growth, and progression. Dro1/ Ccdc80 has been shown to be a potent suppressor of colorectal cancer and ubiquitous inactivation of Dro1/Ccdc80 strongly promoted colorectal carcinogenesis in Apc Min/+ mice and in a chemically-induced colorectal cancer model. The aim of the present study was to investigate whether Dro1/Ccdc80's tumor suppressive function is tumor-cell-autonomous. Expression of Dro1/Ccdc80 in cancer cells had no effect on both colon tumor development in Apc Min/+ mice and formation of xenograft tumors. In contrast, DRO1/CCDC80 loss in the microenvironment strongly increased tumor growth in xenograft models, inhibited cancer cell apoptosis, and promoted intestinal epithelial cell migration. Moreover, stromal Dro1/Ccdc80 inactivation facilitated formation of intestinal epithelial organoids. Expression analyses showed Dro1/Ccdc80 to be significantly down-regulated in murine gastric cancer associated fibroblasts, in Apc Min/+ colon tumor primary stromal cells and in microdissected stroma from human colorectal cancer compared to normal, non-tumor stroma. Our results demonstrate epithelial derived DRO1/CCDC80 to be dispensable for intestinal tissue homeostasis and identify Dro1/Ccdc80 as tumor suppressor in the tumor microenvironment.

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DRO1/CCDC80: a Novel Tumor Suppressor of Colorectal Carcinogenesis

Grill

Kolligs

2015

Curr Colorectal Cancer Rep

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Dro1/Ccdc80 has been identified as a tumor suppressor gene in colorectal, thyroid, and ovarian cancer. Dro1/ Ccdc80 is ubiquitously expressed and has, next to its tumor suppressive role, been implicated in a wide range of biological processes, including adipogenesis, lens development, and skeletogenesis. DRO1/CCDC80 is a secreted protein that assembles with the extracellular matrix and promotes cell adhesion. The biological mechanisms by which DRO1/CCDC80 exerts its various functions are still widely unknown. DRO1/ CCDC80 inhibits malignant growth properties of cancer cells, mediates sensitization to apoptosis, regulates E-cadherin expression, and acts as a binding partner for Janus kinase 2 and cyclic GMP-dependent protein kinase 1. Moreover, DRO1 has been linked to MEK/ERK, fibroblast growth factor (FGF), Hedgehog, and Wnt/β-catenin signaling. In the following, DRO1/CCDC80 is presented as a novel tumor suppressor of colorectal carcinogenesis.

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DRO1/CCDC80: a Novel Tumor Suppressor of Colorectal Carcinogenesis

Cited by 3 publications

References 40 publications

Oncogenes and tumor suppressor genes: functions and roles in cancers

Oncogenes and tumor suppressor genes: functions and roles in cancers

Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis

DRO1/CCDC80: a Novel Tumor Suppressor of Colorectal Carcinogenesis

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