Drug delivery property, antibacterial performance and cytocompatibility of gentamicin loaded poly(lactic-co-glycolic acid) coating on porous magnesium scaffold

Impact of PLA/Mg films degradation on surface physical properties and biofilm survival

“…The PLA films do not modify this pH, but the films with Mg seem to counteract this effect, increasing the pH. Some studies ensure that the alkalinity of Mg is compensated for by the acid products released in the degradation of polymers, PLGA [47] or PLA [48]. In any case, this pH value is not sufficiently alkaline to cause irreversible damage to bacteria inside the biofilm, despite the fast Mg 2+ release, and conversely, there is an increase in the biofilm formation at 24 h. Similarly, Sánchez et al [49] compared the in vitro and in vivo corrosion rates and indicated that the corrosion rate in vivo was 1-4 times lower than the corrosion rate in vitro, which means that probably the changes in pH could be even lower in in vivo conditions.…”

The application of nanomaterials in controlled drug delivery for bone regeneration

“…In their work, the Mg based nanocomposites were used as a controlled antibiotic delivery system. The result showed that the nanocomposite exhibited constant drug release for >14 days in the local sites of bone defects and more evidently prevented bacterial adhesion, compared with pure Mg . Sun et al developed self‐assembled colloidal particles/Mg alloys (Mg‐Ca) nanocomplex loaded with vitamin M. The nanocomplex significantly decreased the corrosion rate of the alloy.…”