Drug delivery system in bone biology: an evolving platform for bone regeneration and bone infection management

Rama, M.; Vijayalakshmi, Uthirapathy

doi:10.1007/s00289-022-04442-5

Cited by 6 publications

(9 citation statements)

References 162 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A drug delivery system can be designed to regulate the osteogenic microenvironment by releasing bioactive molecules locally, thereby promoting bone repair. 112 In this section, we summarize and discuss recent research progress on the regulation of microenvironments by NP drug delivery systems in various complex osteogenic scenarios.…”

Section: Np-based Drug Delivery Systems For Regulating Osteogenic Mic...mentioning

confidence: 99%

“…Under pathological conditions such as infection and osteoporosis, the microenvironment of bone formation is damaged and the process of bone repair is hindered. A drug delivery system can be designed to regulate the osteogenic microenvironment by releasing bioactive molecules locally, thereby promoting bone repair . In this section, we summarize and discuss recent research progress on the regulation of microenvironments by NP drug delivery systems in various complex osteogenic scenarios.…”

Section: Np-based Drug Delivery Systems For Regulating Osteogenic Mic...mentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Xu,

Cui,

Tian

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

The treatment of bone defects has been a long-standing challenge in clinical practice. Among the various bone tissue engineering approaches, there has been substantial progress in the development of drug delivery systems based on functional drugs and appropriate carrier materials owing to technological advances in recent years. A large number of materials based on functional nanocarriers have been developed and applied to improve the complex osteogenic microenvironment, including for promoting osteogenic activity, inhibiting osteoclast activity, and exerting certain antibacterial effects. This Review discusses the physicochemical properties, drug loading mechanisms, advantages and disadvantages of nanoparticles (NPs) used for constructing drug delivery systems. In addition, we provide an overview of the osteogenic microenvironment regulation mechanism of drug delivery systems based on nanoparticle (NP) carriers and the construction strategies of drug delivery systems. Finally, the advantages and disadvantages of NP carriers are summarized along with their prospects and future research trends in bone tissue engineering. This Review thus provides advanced strategies for the design and application of drug delivery systems based on NPs in the treatment of bone defects.

show abstract

Section: Np-based Drug Delivery Systems For Regulating Osteogenic Mic...mentioning

confidence: 99%

Section: Np-based Drug Delivery Systems For Regulating Osteogenic Mic...mentioning

confidence: 99%

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Xu,

Cui,

Tian

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…22 Drug inclusion via the chemical method can reduce burst release and result in prolonged drug release from the polymeric scaffold. 23 In this work, we report a flexible bioactive drug-loaded nanofibrous scaffold by blending different concentrations of CEM into spinning solutions for fabrication. PLA:PVA/ HAP:TiO 2 /CEM nanofibrous scaffolds could provide an ideal microenvironment for cell migration and proliferation and enhance the prolonged antibacterial effect.…”

Section: Introductionmentioning

confidence: 99%

“…The study anticipated that strong interactions between biocompatible CEM and the composite nanofiber could increase the in vivo antibacterial effect over 20 days . Drug inclusion via the chemical method can reduce burst release and result in prolonged drug release from the polymeric scaffold …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication and In Vitro Drug Delivery Evaluation of Cephalexin Monohydrate-Loaded PLA:PVA/HAP:TiO₂ Fibrous Scaffolds for Bone Regeneration

2023

Self Cite

View full text Add to dashboard Cite

Owing to the excellent osteoconductive property of hydroxyapatite, we aimed to design a cephalexin monohydrate-loaded PLA:PVA/HAP:TiO 2 nanofibrous scaffold to improve the drug delivery efficiency toward bone regenerative applications. In this study, HAP:TiO 2 (anatase and rutile phases) samples were prepared by a coprecipitation method, which were later blended with PLA:PVA polymeric solution (with and without the drug) to fabricate a nanofibrous matrix via the electrospinning technique. All the prepared samples were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, contact angle, porosity, and tensile strength tests. Further, in vitro biodegradation and the drug-releasing ability were examined by varying the concentration of cephalexin monohydrate in the composite matrix. Deposition of the apatite layer on the scaffolds was examined after incubation in simulated body fluid solution to confirm the bioactivity of the prepared nanofibers. Biocompatibility by the MTT assay and osteogenic differentiation by ARS staining were evaluated by culturing MG63 cells on PLA:PVA/HAP:TiO 2 nanofibers, which could ensue better support for cell proliferation. Consequently, the sustained release profile and better biocompatibility of the scaffolds revealed a strong potential use in bone regenerative applications. ■ HIGHLIGHTS• Antibiotic drug-embedded anatase-and rutile-phase TiO 2 /HAP nanofibrous scaffolds were successfully fabricated using an electrospinning technique. • Antibiotic drug CEM-loaded PLA:PVA/HAP:TiO 2 electrospun nanofibrous scaffolds revealed a better sustained release and antibacterial efficacy, and osteogenic differentiation was examined by ARS staining. • The mechanical study, hemocompatibility assay, and cell viability assessment were compared and interpreted for effective use of the prepared nanofibers in bone regenerative applications. • The incorporation of CEM in spinning solution forms strong covalent linkages that can enhance better releasing progress than the scaffolds loaded via physical adsorption.

show abstract

A pH/ROS-responsive antioxidative and antimicrobial GelMA hydrogel for on-demand drug delivery and enhanced osteogenic differentiation in vitro

Qi,

Wang,

Wang

et al. 2024

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Drug delivery system in bone biology: an evolving platform for bone regeneration and bone infection management

Cited by 6 publications

References 162 publications

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Fabrication and In Vitro Drug Delivery Evaluation of Cephalexin Monohydrate-Loaded PLA:PVA/HAP:TiO₂ Fibrous Scaffolds for Bone Regeneration

A pH/ROS-responsive antioxidative and antimicrobial GelMA hydrogel for on-demand drug delivery and enhanced osteogenic differentiation in vitro

Contact Info

Product

Resources

About

Drug delivery system in bone biology: an evolving platform for bone regeneration and bone infection management

Cited by 6 publications

References 162 publications

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Fabrication and In Vitro Drug Delivery Evaluation of Cephalexin Monohydrate-Loaded PLA:PVA/HAP:TiO2 Fibrous Scaffolds for Bone Regeneration

A pH/ROS-responsive antioxidative and antimicrobial GelMA hydrogel for on-demand drug delivery and enhanced osteogenic differentiation in vitro

Contact Info

Product

Resources

About

Fabrication and In Vitro Drug Delivery Evaluation of Cephalexin Monohydrate-Loaded PLA:PVA/HAP:TiO₂ Fibrous Scaffolds for Bone Regeneration