Drug-eluting stent fracture and acute coronary syndrome

Coronary Stent Fracture: A Recently Appreciated Phenomenon with Clinical Relevance

“…[5] and Chhatriwalla et al . [17] found that more than 95% of their stent fracture cases had occurred in the Cypher Stent, and Lee et al . in their analysis 3636 of Cypher Stents and 1162 Taxus Stents in 530 patients, reported a stent fracture prevalence of 1.9%, all in the Cypher Stents [1].…”

“…also showed a greater incidence of binary restenosis in their group of patients with stent fracture (one patient with stent fracture presented with non ST-elevation myocardial infarction [NSTEMI]), but there was no difference in terms of clinical manifestation between patients with or without stent fracture [18]. In contrast, other investigations have suggested that stent fracture could be potentially harmful [17]. Chhatriwalla et al .…”

Trend to move from permanent metals to degradable, multifunctional polymer or metallic implants in the example of coronary stents

“…Such continuously acting forces can lead to small cracks over time, which in the following might induce breaks and dysfunctional implants. Recently, fractures of metal stent struts have been recognized as a complication that may result in thrombosis, perforation, restenosis, and migration of the stent, effecting morbidity and mortality [16]. This places special demands on the molecular structure of stents.…”

Coronary artery stent fracture with in-stent restenosis and aneurysm formation: Diagnosis and successful treatment with graft stent implantation

“…Stent fracture by itself can lead to stent thrombosis, in-stent restenosis, coronary artery aneurysm formation and myocardial infarction [3][4][5]. Incidence of stent fracture ranges from 1 to 8% as described in previous…”