Drug-Induced Anemia and Other Red Cell Disorders: A Guide in the Age of Polypharmacy

Shander, Aryeh; Javidroozi, Mazyar; Ashton, Maria E.

doi:10.2174/157488411798375895

Cited by 33 publications

(13 citation statements)

References 47 publications

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“…Red blood cells (RBC) are the most abundant cell type in the blood and play an essential role in oxygen transfer. Several natural plant extracts and compounds of plants and/fungi, such as saponins, phenylhydrazine, penicillin, and cephalosporin induce haemolysis and result in erythrokatalysis [51][52][53][54]. Haemolysis of the RBC results in an exposure of intracellular phosphatidylserine, which accelerates blood coagulation and hyper-coagulable states [55].…”

Section: Discussionmentioning

confidence: 99%

Anti-Thrombotic, Anti-Oxidant and Haemolysis Activities of Six Edible Insect Species

Pyo

Kang

Jung

et al. 2020

Foods

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In Korea, various insect species such as crickets and grasshoppers, as well as honey bee and silkworm pupae, have been consumed as food and used in oriental medicine. In this study to evaluate useful the bioactivities and potentially adverse effects of edible insects, ethanol extracts of Allomyrina dichotoma (AD), Tenebrio molitor (TM), Protaetia brevitarsis (PB), Gryllus bimaculatus (GB), Teleogryllus emma (TE), and Apis mellifera (AM) were prepared and evaluated with regard to their anti-thrombosis, anti-oxidant and haemolysis activities against human red blood cells. AD and TE extracts showed strong anti-oxidant activities, which were not related to polyphenol content. All ethanol extracts, except AM extract, showed strong platelet aggregation activities. The platelet aggregation ratios of the extracts were 194%–246% of those of the solvent controls. The effects of the AD, TM, PB, GM, and AM extracts on thrombin, prothrombin and various coagulation factors were negligible. Only the extract of TM showed concentration-dependent anti-coagulation activities, with a 1.75-fold aPTT (activated Partial Thromboplastin Time) extension at 5 mg/mL. Of the six insect extracts, TM and AM extracts exhibited potent haemolytic activity. Our results on the insect extracts’ functional properties suggest that edible insects have considerable potential not just as a food source but as a novel bio-resource as well.

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Section: Discussionmentioning

confidence: 99%

Anti-Thrombotic, Anti-Oxidant and Haemolysis Activities of Six Edible Insect Species

Pyo

Kang

Jung

et al. 2020

Foods

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“…Finally, the patient was receiving valsartan, and angiotensin II receptor blockers are associated with suppression of endogenous erythropoietin production and can contribute to anemia. 38…”

Section: Preoperative Management Of Anemiamentioning

confidence: 99%

How I treat anemia in the perisurgical setting

Shander

Kaufman²,

Goodnough

2020

Blood

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Anemia is a common finding in perioperative setting with significant untoward consequences including worsening of outcomes and diminished quality of life as well as increased risk of allogeneic blood transfusions. Here we present three cases that illustrate how anemia can be perioperatively managed in patients undergoing cardiac, orthopedic and oncology surgeries. Timely detection of anemia prior to high-blood loss surgeries can allow clinicians to manage it and optimize hemoglobin level, making patients better prepared for the surgery. Treatment of anemia should be guided by the etiology and may include erythropoietic agents, folic acid, B12 and iron preparations. Other blood management strategies geared toward reducing surgical blood loss such as autologous transfusion techniques and agents to optimize hemostasis are employed during surgery and in the immediate post-operative period. Patients should be closely monitored following the surgery for signs of ongoing bleeding in need of control. Finally, screening for and management of anemia should continue in the post-operative and post-discharge period, as persistence and recurrence of anemia can further undermine patient's outcomes.

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“…The aetiology in the remaining group is often unclear [8]. Latrogenic anaemia or drug induced immune hemolytic anaemia (DIIHA) should be underscored with a growing list of commonly used medications being implicated [9].…”

Section: Causes Of Ida In Pregnancy Womenmentioning

confidence: 99%

A Prospective Study on Risk Factors of Iron Deficiency Anemia in Pregnant Women and Their Management

Kumar¹,

Raja²,

Sreeveena³

et al. 2020

Int J Curr Pharm Sci

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Objective: Iron deficiency anemia during pregnancy leads to preterm birth, low birth weight and increases the incidence of postpartum hemorrhage (PPH) and the reason for the incidence of PPH is higher in India compared with the rest of the world. In this study, our main goal was to find out the risk factors and complications of iron deficiency anemia and their management in pregnant women. Methods: It is a prospective study done at Obstetrics and Gynecology Department in Government District Headquarters Hospital, Tiruppur. All subjects were analyzed in full detail and hemoglobin estimation was also done to the patients. Results: Study found that 52% shows moderate anemia followed by 30% mild and 18% severe, respectively. Risk factors are found in 55% cases. Study found an association between risk factors and severity of anemia. Conclusion: Iron deficiency anemia continues to be the commonest etiology of anemia in pregnancy. The prevalence of iron deficiency in a pregnant woman is amongst the highest in the world. Untreated iron deficiency has significant adverse feto-maternal consequences. Iron supplementation and antenatal care are the basic requirements to prevent anemia.

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Drug-Induced Anemia and Other Red Cell Disorders: A Guide in the Age of Polypharmacy

Cited by 33 publications

References 47 publications

Anti-Thrombotic, Anti-Oxidant and Haemolysis Activities of Six Edible Insect Species

Anti-Thrombotic, Anti-Oxidant and Haemolysis Activities of Six Edible Insect Species

How I treat anemia in the perisurgical setting

A Prospective Study on Risk Factors of Iron Deficiency Anemia in Pregnant Women and Their Management

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