“…Cyclosporine is useful because immunocompetent lymphocytes in the G0 and G1 phases of the cell cycle are directly and reversibly blocked by it. Research has shown that cyclosporine inhibits CD4 + CD25 + Trigs, which may obstruct the ability for host immune tolerance ( Liddicoat and Lavelle, 2019 ; Masi et al, 2019 ).…”
“…Cyclosporine is useful because immunocompetent lymphocytes in the G0 and G1 phases of the cell cycle are directly and reversibly blocked by it. Research has shown that cyclosporine inhibits CD4 + CD25 + Trigs, which may obstruct the ability for host immune tolerance ( Liddicoat and Lavelle, 2019 ; Masi et al, 2019 ).…”
“…16 L'élévation de la PA semble être plus importante chez les personnes âgées, lors de surcharge pondérale ou lors d'HTA préexistante. 17 De plus, le risque relatif d'HTA est plus élevé chez les patients atteints d'un cancer du sein, du rein ou de la prostate et s'avère être plus bas chez ceux n'ayant jamais reçu de chimiothérapie. 16 Finalement, l'apparition d'une hypertension pourrait être prédictive d'une réponse au traitement oncologique comme cela a été démontré de manière rétrospective pour le bévacizumab dans le cancer métastatique colorectal.…”
“…3 Un dépistage d'éventuels FRCV est fondamental chez tout patient, notamment atteint de cancer (figure 1). 17 Ainsi, chez un malade prévu pour un traitement oncologique prohyper-…”
Section: Prise En Charge Et Recommandation Pour La Pratique Cliniqueunclassified
Hypertension and cancer : a close relationship to remember!Hypertension is a common clinical problem in patients with cancer. This is explained by its high prevalence in the general population, by the improvement in life expectancy in oncology patients thanks to the progress of anti-cancer therapies, but also by cancer therapy, which is sometimes burdened with cardiovascular toxicity. Early detection of hypertension and proper management are crucial to ensure the continuation of oncology treatment and to protect patients from the consequences of hypertension. Renin-angiotensin system blockers and calcium channel blockers are the first-line treatments.
“…The key role of endothelial cells in regulating tumour physiology, including growth and dissemination, is confirmed by the results of clinical trials documenting a positive impact on cancer prognosis of novel antineoplastic agents that inhibits endothelial cell proliferation. 4,5 In this issue of the European Journal of Preventive Cardiology, Toya et al explore the prospective association between endothelial function, measured at the level of the microcirculation, and future risk of developing solid-tumour cancer. 6 The authors enrolled a population of 687 patients who attended the Mayo Clinic for the assessment of chest pain and/or cardiovascular risk.…”
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confidence: 99%
“…The key role of endothelial cells in regulating tumour physiology, including growth and dissemination, is confirmed by the results of clinical trials documenting a positive impact on cancer prognosis of novel antineoplastic agents that inhibits endothelial cell proliferation. 4,5 Figure 1.Endothelial function as a key regulator of vascular and cancer homeostasis. Endothelium responds to physical and chemical signals by production of a wide range of factors that regulate vascular tone (nitric oxide (NO)), cellular adhesion (vascular cell adhesion protein (VCAM)), cell proliferation (vascular endothelial growth factor (VEGF)) and vessel wall inflammation (interleukin (IL)-1β, IL-6).…”
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