Drug-induced Nail Disorders

Piraccini, Bianca Maria

doi:10.1002/9781119323396.ch16

Cited by 2 publications

(7 citation statements)

References 229 publications

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“…36 Photo-onycholysis tends to spare thumbs with several digits involved; it could be the result of a toxic mechanism or allergic reaction to drugs, and these changes will disappear automatically with drug withdrawal. 20 A previous study had shown that prolonged use of paclitaxel has caused an increase in the incidence of nail changes associated with light exposure. 37 A study conducted on 91 patients revealed that taxanes’ use had caused onycholytic changes in patients taking more than 6 courses of paclitaxel per week.…”

Section: Discussionmentioning

confidence: 99%

“…7 It has been reported that several agents can cause such nail changes as hormones, antimalarial agents, antimicrobials, diuretics, cathartics, and cytotoxic chemotherapeutic drugs. 20 One of the most profound agents to cause this phenomenon are taxanes which are potent chemotherapeutic agents with an outstanding potency and efficacy against a panel of solid tumors. 12 The use of taxanes has increased dramatically over time; this can be explained by their efficacy along with the increase in cancer incidence worldwide.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Nail Lacquer on Taxane-Induced Nail Changes in Women With Breast Cancer

Alshari

Aleshawi

Sharie

et al. 2020

Breast Cancer�(Auckl)

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Objective: Taxane-induced nail changes are considered as an important cosmetic manifestation with an incidence that reaches up to 44% of patients treated with taxane-included therapeutic regimens. In this article, we represent a clinical observational study to evaluate the effect of cosmetic nail lacquer on taxane-induced nail changes in female patients diagnosed with breast cancer. Methods: Prospectively, we identified those women who were diagnosed with breast cancer, scheduled to have AC-Taxol protocol. Any female with previous dermatological or systemic disorders that affect nails was excluded from the study. Patients were categorized into 2 groups based on the utilization of nail lacquer. The first group includes women who started to use the nail lacquer after development of nail changes. The second group comprises those women who did not use the nail lacquer at any occasion. Results: A total of 59 female patients were included in the study; 46 (78%) of them developed nail changes and the main change was nail discoloration. The first group which has used nail lacquer (17, 28.8%) showed an improvement among 15 (78.9%) patients, whereas 2 (7.4%) of them continued to have worsening symptoms. On the contrary, most of the second group (25, 92.9%) did not show any improvement in nail changes. A statistical significance between the tested groups was observed ( P = .000). There is no statistical association between the progression of nail changes and the age of patients. Conclusions: Taxane-induced nail changes are considered as an important clinical, cosmetic, and psychological complication, especially for female patients with cancer. This article suggests that nail lacquer may have an effect in the improvement of nail changes, especially nail discoloration. Further investigations are recommended to prove the efficacy of nail lacquer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Effect of Nail Lacquer on Taxane-Induced Nail Changes in Women With Breast Cancer

Alshari

Aleshawi

Sharie

et al. 2020

Breast Cancer�(Auckl)

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“…Onycholysis following the shape of the proximal nail fold most frequently appears as the only nail feature, but discoloration may also occur. 56,57 The onycholytic edges may be surrounded by a red-brown pigmented zone. 6 Haemorrhage may be an accompanying feature.…”

Section: Circular Onycholysis (Oval or Rounded Onycholysis)mentioning

confidence: 99%

“…In photoonycholysis the lateral margin of the nail is seldom affected. 57 Direct damage to the blood vessels and haemorrhage induced by chemotherapeutic agents such as taxanes may cause multiple subungual haemorrhagic blisters in the centre of the nail bed subsequently leading to onycholysis. 26,57,58 Acute pustular psoriasis of the nail bed may also produce multiple islands of onycholysis in the central area of the nail bed.…”

Section: Circular Onycholysis (Oval or Rounded Onycholysis)mentioning

confidence: 99%

“…57 Direct damage to the blood vessels and haemorrhage induced by chemotherapeutic agents such as taxanes may cause multiple subungual haemorrhagic blisters in the centre of the nail bed subsequently leading to onycholysis. 26,57,58 Acute pustular psoriasis of the nail bed may also produce multiple islands of onycholysis in the central area of the nail bed. 6 Finally, in patients with COVID-19, round onycholytic areas surrounded by erythema and discoloration of the nails has been described, possibly due to localised microvascular damage.…”

Section: Circular Onycholysis (Oval or Rounded Onycholysis)mentioning

confidence: 99%

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Pattern diagnosis of onycholysis

Navarro

2023

JEADV Clinical Practice

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Onycholysis is defined as the detachment of the nail plate from the underlying and/or lateral supporting structures. Trauma, inflammatory conditions, infectious agents, tumours and toxic substances are the most commonly reported causes of onycholysis. We review the main causes of onycholysis in clinical practice and provide a diagnostic approach based on morphologic patterns of the proximal border of onycholysis, as defined by clinical and dermoscopic examination. Four morphologic patterns of onycholysis, namely transversal, lateral, V-shaped and circular are presented with their most common causes and triggers.

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Drug-induced Nail Disorders

Cited by 2 publications

References 229 publications

The Effect of Nail Lacquer on Taxane-Induced Nail Changes in Women With Breast Cancer

The Effect of Nail Lacquer on Taxane-Induced Nail Changes in Women With Breast Cancer

Pattern diagnosis of onycholysis

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