Drug interactions of antihypertensive agents

Opie, Lionel H.

doi:10.1080/20786204.2012.10874206

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…The third was about the need to avoid the consumption of excessive amounts of bananas when taking angiotensin‐converting enzyme (ACE) inhibitors antihypertensives which may increase the risk of developing hyperkalaemia, because of its high potassium content. Hyperkalaemia can cause an irregular heartbeat and heart palpitations 49‐51 . The fourth was about the need to avoid an excessive intake of cranberry and cranberry juice concurrently with vitamin K antagonists anticoagulants, such as warfarin, as it may increase the international normalized ratio (INR) and increase the risk of bleeding 52‐55 …”

Section: Discussionmentioning

confidence: 99%

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The perception of Jordanian population towards concomitant administration of food, beverages and herbs with drugs and their possible interactions: A cross‐sectional study

et al. 2020

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Background Many people are used to administering their drugs with food, beverages or herbs. These substances may contain chemicals that interfere with the prescribed drugs and could potentially lead to changes in their efficacy or safety, and could result in alterations in their pharmacokinetic properties. Objective To assess the extent of the perception and consumption of food, beverages and herbs alongside conventional drugs, along with their potential interactions, specifically in Jordanian society. Methods A descriptive cross‐sectional survey was conducted in Jordan (20 April ‐ 5 May 2020). The survey was developed using Google Forms, then validated and distributed via social media platforms. Data were analysed using Statistical Package for Social Sciences‐24. Main outcome measure Use and perception of food, beverages, herbs and how they interact with drugs among Jordanians. Results Of all the participants (n = 789), 77.8% were females, 46.2% were 50‐year‐olds, 69.7% were married, 70.8% were medically insured, and 51.1% had bachelor's degrees. 70% of the study participants reported use of medicinal plants. About 66% of participants agreed that medicinal plants or herbs could treat diseases and 58.6% thought that medications could interact with drugs. In general, the participants’ knowledge about food/beverage/herb–drug interactions was considered poor. However, a linear regression analysis showed that the level of knowledge was significantly affected (P < .05) by gender, marital status, social status, educational level and employment sector. Conclusion Jordanians have a positive perception towards herbs and their ability to treat diseases. However, their knowledge about food/beverage–drug interactions was poor. There is therefore a need to enhance the community awareness of food/beverage/herb–drug interactions.

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Section: Discussionmentioning

confidence: 99%

“…Hyperkalaemia can cause an irregular heartbeat and heart palpitations. [49][50][51] The fourth was about the need to avoid an excessive intake of cranberry and cranberry juice concurrently with vitamin K antagonists anticoagulants, such as warfarin, as it may increase the international normalized ratio (INR)…”

Section: Discussionmentioning

confidence: 99%

The perception of Jordanian population towards concomitant administration of food, beverages and herbs with drugs and their possible interactions: A cross‐sectional study

et al. 2020

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“…Coadministration of nifedipine with phenytoin, an inducer of CYP3A4, lowers the systemic exposure to nifedipine by approximately 70%. CYP3A inhibitors, such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir, can increase the exposure to nifedipine when coadministered [20]. Agents that can enhance the risk of hemorrhage should be discontinued before the initiation of enoxaparin.…”

Section: Discussionmentioning

confidence: 99%

Significant Drug Interactions Among Intensive Care Unit Patients

Hamidy

Fauzia

2017

Asian J Pharm Clin Res

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Objective: Drug interaction is one factor that contributes to drug-related problems. The hospitalized patients in intensive care units (ICU) have a higher risk for developing drug interactions. The purpose of this study was to evaluate the potency of significant drug interactions in ICU patients.Methods: Drug-drug interactions from patient's medical records from ICU of Arifin Achmad General Hospital in Pekanbaru, Province of Riau, Indonesia at period of July to December 2015 were assessed. Drug Interaction Checker (Medscape) software was used to identify potential drug interactions.Results: This study included 28 ICU patients (mean age, 48 years) who had the potency to drug interactions based on the software. Of these, 29% were male and 71% were female patients. The number of drugs that were given to patients was 3-13 drugs (average 7 drugs per patient). There were 122 potential drug-drug interactions found in this study, including 43% potency of minor or non-significant, 52% potency of significant, 3% potency of serious, and 2% potency of contraindicated drug interactions. A total of 67% were pharmacodynamics and 33% were pharmacokinetics interactions. Dexamethasone, ketoprofen, ketorolac, furosemide, nifedipine, and enoxaparin were among drugs with the highest frequency of potential drug interactions. Conclusion:Significant drug-drug interactions were prevalent in the ICU patients. This may be due to the complexity of the pharmacotherapies administered. The health professionals who provide care to these patients should be aware to identify and prevent possible drug events.

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“…Since multiple drugs are used in hypertensive patients and often these patients have other co-existing conditions, common drug interactions should be kept in mind, as shown in Table 12. 72 The sequence of drug therapy after choosing an initial agent depends on the response to the first. In case target BP is not achieved, combination should be used in a manner shown in Figure 4.…”

Section: Drug Interactionsmentioning

confidence: 99%