Drug-loaded PLCL/PEO-SA bilayer nanofibrous membrane for controlled release

Wang, Lei; Liu, Yi; Li, Tingxiao; Xin, Binjie

doi:10.1080/09205063.2021.1970881

Cited by 11 publications

(5 citation statements)

References 42 publications

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“…Hence, it is expected that targeted wound healing can be achieved by combining swelling, erosion, and subsequent drug diffusion kinetics as part of the controlled drug release mechanism (9,20). This is also evident in some of the recently published studies, in which the reported drug release from the prepared wound dressings is explained by a combined mechanism of either two or three of the aforementioned principles (21,22). Among the commonest methods for testing the in vitro drug release of topical and transdermal formulations is using Franz diffusion cells (23,24).…”

Section: Introductionmentioning

confidence: 90%

The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings

Maver¹,

Maver

2023

AMB

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Purpose: Wound dressings are one of the most commonly used products in wound care. Nowadays, various wound dressings are developed containing different active ingredients, often drugs from different pharmacodynamic groups. Considering the variable and changing environment in each wound type, it is important that the experimental design for evaluating the in vitro drug release of such materials takes into account these different conditions. Methods: For this purpose, Franz diffusion cells for in vitro drug release testing are the method of choice, as they are not only able to simulate different conditions during wound healing but also allow for a certain degree of possible changes in the experimental design (e.g., diffusion cell size). Results: In this study, we aimed to compare two Franz diffusion cells with different volumes of receptor medium to evaluate naproxen release from an alginate-based model wound dressing. We confirmed that the volume of the receptor medium not only affects the amount of drug released in the selected time but also significantly influences the release mechanism. Conclusion: The different volumes of the Franz diffusion cell receptor compartments allow the simulation of wounds with a higher and a lower degree of exudation. The experimental design for in vitro drug release testing based on Franz diffusion cells must be based on a thorough consideration of the targeted wound type for which the dressings are being developed.

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Section: Introductionmentioning

confidence: 90%

The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings

Maver¹,

Maver

2023

AMB

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“…This unique composition contributes to its properties, including biodegradability, excellent biocompatibility, and innocuous nature to the human body. The versatility of PLCL finds extensive application in the biomedical field due to these merits 3 . Remarkable mechanical behavior, such as its pronounced plasticity and a controlled degradation rate, further underscore its suitability for various applications.…”

Section: Introductionmentioning

confidence: 99%

“…The versatility of PLCL finds extensive application in the biomedical field due to these merits. 3 Remarkable mechanical behavior, such as its pronounced plasticity and a controlled degradation rate, further underscore its suitability for various applications. However, a limitation of PLCL lies in the reduced hydrophilicity that impacts certain aspects of its performance.…”

mentioning

confidence: 99%

Biodegradable electrospun poly(L‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering

de Souza,

Cardoso,

de Toledo

et al. 2024

J Biomed Mater Res

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The field of tissue engineering has witnessed significant advancements in recent years, driven by the pursuit of innovative solutions to address the challenges of bone regeneration. In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L‐lactide‐co‐ε‐caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate‐chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone‐derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently enhancing hydrophilicity. Thermal gravimetric analysis confirmed the efficient incorporation of BG, with the scaffolds demonstrating thermal stability up to 250°C. Mechanical testing revealed enhanced tensile strength and Young's modulus in the presence of BG; however, the elongation at break decreased. Cell viability assays demonstrated improved cytocompatibility, especially in the PLCL/PEG+BG group. Alizarin red staining indicated enhanced osteoinductive potential, and fluorescence analysis confirmed increased cell adhesion in the PLCL/PEG+BG group. Our findings suggest that the PLCL/PEG/BG composite scaffold holds promise as an advanced biomaterial for bone tissue engineering.

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“…PEO is a water-soluble polymer that exhibits excellent biocompatibility, non-immunogenicity, and non-toxicity. It resists the non-specific adsorption of proteins and is frequently used to develop various drug carriers and anti-adsorption coatings 146 . In the field of hemostatic material development, PEO is primarily used as an additive to improve the performance of other active ingredients.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the medical applications of hemostatic materials

Yu¹,

Wang²,

Liu³

et al. 2023

Theranostics

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Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials. Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials.

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Drug-loaded PLCL/PEO-SA bilayer nanofibrous membrane for controlled release

Cited by 11 publications

References 42 publications

The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings

The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings

Biodegradable electrospun poly(L‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering

Recent advances in the medical applications of hemostatic materials

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