Drug metabolism in spontaneously diabetic guinea pigs

Cook, David E.; Jackson, Jessica; Past, Marilyn R.; Lang, Charles; Bullock, Loïc

doi:10.1007/bf01951983

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Both sexes exhibited hyperinsulinemia (4 times above normal). In such condition, inhibition of the hepatic drug metabolism occurred in male diabetic guinea pigs, but no such effect had been caused by diabetes in females [31]. This can demonstrate the effect of gender along with the DM on the metabolism.…”

Section: Animal Studiesmentioning

confidence: 78%

Effect of Diabetes Mellitus on the Metabolism of Drugs and Toxins

Houshang¹

2015

J Clin Toxicol

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Diabetes mellitus (DM) is a complicated endocrine disorder that can clinically impair tissues and organs due to hyperglycemia. One of the areas of concern in diabetes would be the higher amount of medications being consumed by diabetes sufferers that is the corollary of its inevitable complications such as micro-and macro-vascular damages to various organs. Different metabolic pathways are involved in the biotransformation of drugs and toxins, thus their pharmacokinetic/toxicokinetic can be affected by DM primarily due to changes in enzymes and drug transporters. On the other hand, different enzymatic pathways are involved in the metabolic processes of substances. While not many human studies are available, several investigations have been carried out in animal models of diabetes, the majority of them being rodents. Given the high prevalence of DM and its important complications, the effect of this disease on the metabolism of some of the toxins and drugs is discussed herein.

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Section: Animal Studiesmentioning

confidence: 78%