Drug-Resistant Tuberculosis at the University Hospital in Gaziantep, South-Eastern Turkey

Balcı, İclal; Dikensoy, Öner; Bayram, Ayşen; Filiz, Ayten

doi:10.1177/147323000002800606

Cited by 16 publications

(12 citation statements)

References 7 publications

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“…In 2005, Surucuoglu and colleagues reported that the rate of resistance to any anti-TB drugs among 355 isolates of Mycobacterium tuberculosis obtained from western Turkey was 21.1%, while another study found that among the 1,513 TB cases diagnosed in Istanbul, Turkey, in 2005, 19% were resistant to at least one drug (20,25). These rates are similar to the rates of drug resistance found in some of the Eastern European countries that are considered to have the highest drug resistance rates in the world (3). The high drug resistance rate poses a major challenge to the control of TB in Turkey.…”

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confidence: 68%

“…Although the TB incidence in Turkey has decreased by half since 1985, several studies have shown the proportion of drugresistant TB cases to be higher than the global average (3,5,10,11,20,24,26). In 2005, Surucuoglu and colleagues reported that the rate of resistance to any anti-TB drugs among 355 isolates of Mycobacterium tuberculosis obtained from western Turkey was 21.1%, while another study found that among the 1,513 TB cases diagnosed in Istanbul, Turkey, in 2005, 19% were resistant to at least one drug (20,25).…”

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confidence: 99%

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Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

et al. 2010

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Drug-resistant tuberculosis (TB) presents a major challenge to global TB control. To gain a better understanding of drug-resistant TB epidemiology in Malatya, Turkey, we conducted the present study using 397 Mycobacterium tuberculosis clinical isolates collected from Malatya, Turkey, in recent years (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007). Resistance to any anti-TB drug was found in 29% (114 of 397) of the study isolates, while the multidrug resistance (MDR) rate was ϳ4.5% (18 of 397). Resistances to isoniazid (15.5%) and streptomycin (13.4%) were about twice as high as resistance to rifampin (RMP) (6.3%) and ethambutol (EMB) (6.0%). Importantly, 28% (7 of 25) of the RMP-resistant isolates were non-MDR isolates, as when a significant proportion of RMPresistant isolates in a population are non-MDR, the predictive value of molecular detection of RMP resistance for MDR can be significantly reduced. Both identical and varied drug resistance patterns were seen in the same genotyping-defined clusters, suggesting that both primary and acquired resistance have contributed to the drug-resistant TB epidemic in Malatya, Turkey. In addition, drug-resistant cases were found to be more likely to be males (odds ratio [95% confidence interval], 1.82 [1.13, 2.94]), suggesting a potential role of gender in the epidemiology of drug-resistant TB in the study population. This study demonstrates that the integration of drug susceptibility testing with genotyping and epidemiological data analysis represents a useful approach to studying the epidemiology of drug-resistant TB.

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confidence: 68%

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confidence: 99%

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

et al. 2010

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“…Ülkemizde yapılan çalışmalarda TB izolatlarında en az bir ilaca direnç %15-35 arasında bulunmuştur 15,16 . Bölgemizde yapılan bir çalışmada ilaç direnci %40.2 gibi yüksek bir oranda saptanmıştır (17). Literatürde yapılan TB konusunda yapılan geniş bir taramada izolatlarda ÇİD oranları en yüksek olarak şu ülkelerde bildirilmiştir; Nepal (%48), Gujarat, Hindistan (%34), New York (%30), Bolivya ve Kore ( her biri %15) 18 .…”

Section: Discussionunclassified

Factors that affect the transmission risk during contact with multi drug resistant tuberculosis

Abakay

Tanrıkulu²,

Abakay³

et al. 2010

J Clin Exp Invest

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Objectives: The aim of this study was to investigate the contact examination results of patients with multi-drug resistant tuberculosis (MDR-TB), their clinical characteristics and risk factors for tuberculosis (TB) transmission. Methods:Follow-up charts of 34 MDR-TB patients, who are registered in four tuberculosis dispensaries in Diyarbakir and followed-up between January 2000 and December 2008 were analyzed retrospectively. Results:The mean age of MDR-TB patients was 32.3±14.2 years. Among the person who in contact with MDR-TB index patients, 7 (20.6%) of them had TB while overall 9 contact persons developed TB disease. No significant differences were found in gender distribution, education and social security status, monthly income and past TB history between contact person who developed (n=7) and not-developed (n=27) TB disease (p>0.05).In 17 (50.0%) of MDR-TB patients inappropriate anti-TB drug prescription and in 14 (41.1%) non-compliance to drug regimen were detected. Inappropriately prescribed anti-TB drugs and delay in TB diagnosis for index MDR-TB patients (18.7 months vs. 9.3 months, respectively; p<0.05) were more frequently encountered among contact persons who developed TB (p<0.05). The mean number of contact person for MDR-TB patients was 4.4 and 1.8 person per patient had been examined. Examination ratios for MDR-TB contact persons who did not developed TB disease was lower than those of TB developed patients (15.6% vs. 50.0%, respectively; p<0.05) Conclusion: Insufficient follow-up and delay in diagnosis in MDR-TB patients may be significant risk factors on their contact persons; therefore it is necessary to increase the screenings and precautions in these contacts. Bulgular: ÇİD-TB hastalarının yaş ortalaması 32.3±14.2 yıl idi. ÇİD-TB hastalarıyla temaslı olanların 7'sinde (%20 .6) ve toplam 9 temaslıda TB saptandı. Kaynak ÇİD-TB vakaları temaslılarında TB gelişmeyen (n=27) ve gelişen (n=7) olarak iki gruba ayrılarak yapılan değerlendirmeler-de cinsiyet, eğitim durumu, sosyal güvenceye sahip olma, aylık gelir düzeyi, oturduğu yer, özgeçmişinde TB öyküsü olması açısından anlamlı fark saptanmadı (p>0.05). Kaynak ÇİD-TB vakalarının 17'sinde (%50) tedavi uygunsuzluğu, 14'ünde (%41.1) tedavi uyumsuzluğu saptandı. Temaslılarında TB gelişen ÇİD-TB grubunda tedavi uygunsuzluğu daha sık olarak saptandı (p<0.05). Tanı gecikmesi, temaslılarında TB gelişen vakalarda ortalama 18.7 ay, temaslılarında TB gelişmeyenlerde ise ortalama 9.3 ay olarak saptandı ve aradaki fark anlamlıydı (p<0.05). ÇİD-TB vakalarında hasta başına ortalama 4.4 temaslı kaydedilmişti ve hasta başına ortalama 1.8 kişi muayene edilmişti. Temaslılarında TB gelişmeyen ÇİD-TB grubunda temaslı muayene oranı %15.6 iken, TB gelişmeyenler-de %50 olarak saptandı ve bu fark anlamlıydı (p<0.05).Sonuç: ÇİD-TB temasında TB enfeksiyonu bulaşması açısından, takiplerdeki uygunsuzluklar ve tanı gecikmesi önemli risk faktörleri olarak gözükmektedir. ÇİD-TB temaslılarında tarama ve takiplerinin artırılması ve hasta ve temaslıların bulaşma riski h...

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“…Hemangiomas usually expansively grow and disrupt the cortex thus they can be misdiagnosed as agressive tumors or infectous processes (4). Mycobacterium tuberculosis infection with drug resistant species is highly prevalent in southeastern Turkey (5). Mycobacterial infection of the thoracic cage is rare and is difficult to discern clinically and on radiographs (6).…”

Section: Introductionmentioning

confidence: 99%

An Unusual Case of Cavernous Hemangioma of the Rib in a Young Man with Lung Tuberculosis: A Brief Review and Case Report

Oruc

Atay

Karabulut³

et al. 2013

Intern. Med.

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Hemangiomas are benign vascular tumors that usually involve the liver, skin, eyes and central nervous system. Hemangioma of the bone is unusual and is generally observed in the vertebrae or skull while hemangioma of the costae is extremely rare. Hemangioma of the rib and chest wall tuberculosis may be misdiagnosed as chest wall tumors. We herein report a case of hemangioma of the rib with a tuberculosis infection of the pleura.

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Drug-Resistant Tuberculosis at the University Hospital in Gaziantep, South-Eastern Turkey

Cited by 16 publications

References 7 publications

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

Factors that affect the transmission risk during contact with multi drug resistant tuberculosis

An Unusual Case of Cavernous Hemangioma of the Rib in a Young Man with Lung Tuberculosis: A Brief Review and Case Report

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