Dual-cross-linked dynamic hydrogels with cucurbit[8]uril and imine linkages

Abstract

Dual cross-linking of hydrogels with fast and slow crosslinks enhances both the mechanical and dynamic properties of dynamic hydrogels.

Supramolecular topology controlled self-healing conformal hydrogels for stable human–machine interfaces

“…Although the use of an appropriate amount of methylene bisacrylamide (MBA) as a covalent crosslinking agent may be a choice to improve the cohesion of hydrogels, 19 this greatly affects the self-healing properties, and the hydrogel cannot be reused after being damaged. Compared with covalent crosslinking, topology based on host-guest supramolecular interactions can not only endow hydrogels with cohesion and self-healing properties, [20][21][22][23][24] but this can also prolong the service life of conformal hydrogels.…”

Stimuli‐Responsive, Self‐Healing, and Injectable Hydrogels with Dual‐Crosslinked Design from Phenolphthalein‐Grafted N‐Carboxyethyl Chitosan

“…In general, an imine bond is sensitive to the pH, at which transition from sol to gel state can occur. [ 23,36 ] As shown in Figure , the POCH2 hydrogel changed to a sol, when the pH was adjusted to 2. This was due to protonation of amino groups in the acidic environment, breaking imine bond, and deforming the hydrogel.…”

“…[ 18 ] With the improved properties, the hydrogel system can be designed and developed by using various interactions, for example, imine/boronate ester linkages, [ 19 ] imine/Diels–Alder reaction linkages, [ 20 ] boronate ester/acylhydrazone linkages, [ 21 ] boronate ester/hydrogen bond linkages, [ 22 ] and imine/host–guest linkages. [ 23 ] To date, most research has been restricted to non‐ or partially biobased polysaccharides.…”

Influencing factors and characterization methods of nanoparticles regulating amyloid aggregation

“…89,90 The commonly used reagents are citrate, 91 curcumin, 92 capsaicin 93 and alginate, 94 which can improve the inhibition of Aβ aggregation or even break down amyloid fibrils. In addition, calixarene, 95 cyclodextrin 96 and cucurbituril 97 have been used for specific recognition of the lysine, glutamate, aspartate, tyrosine and phenylalanine residues of amyloids through host–guest interactions. These multivalent host–guest interactions better trap Aβ monomers and fibrils on the surface of NPs and inhibit the abnormal fibrillation process of amyloid.…”