Dual-crosslinked methylcellulose hydrogels for 3D bioprinting applications

Shin, Ji Youn; Yeo, Yong Ho; Jeong, Jae Eun; Park, Su A; Park, Won Ho

doi:10.1016/j.carbpol.2020.116192

Cited by 83 publications

(59 citation statements)

References 45 publications

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“… 179 Normalization of the diameter measured on the printed filament to the needle diameter results in the spreading ratio. 51 Further, the filament diameter at the intersection of two filaments 180 can be used as an indicator of how well these are stacked and how the filaments may deform due to surface tension. Fusion is accompanied by an increase in diameter in x – y plane, as the filament relaxes and spreads onto the underlying layer ( Figure 6 Bii).…”

Section: Assessment Of Printability and Shape Fidelitymentioning

confidence: 99%

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

et al. 2020

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Three-dimensional bioprinting uses additive manufacturing techniques for the automated fabrication of hierarchically organized living constructs. The building blocks are often hydrogel-based bioinks, which need to be printed into structures with high shape fidelity to the intended computer-aided design. For optimal cell performance, relatively soft and printable inks are preferred, although these undergo significant deformation during the printing process, which may impair shape fidelity. While the concept of good or poor printability seems rather intuitive, its quantitative definition lacks consensus and depends on multiple rheological and chemical parameters of the ink. This review discusses qualitative and quantitative methodologies to evaluate printability of bioinks for extrusion- and lithography-based bioprinting. The physicochemical parameters influencing shape fidelity are discussed, together with their importance in establishing new models, predictive tools and printing methods that are deemed instrumental for the design of next-generation bioinks, and for reproducible comparison of their structural performance.

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Section: Assessment Of Printability and Shape Fidelitymentioning

confidence: 99%

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

et al. 2020

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“…[34,85] Although MC can form a viscous hydrogel network, its poor mechanical properties limits its application for bioprinting in unmodified form. To address this issue, Shin et al [86] in a recent study developed a dual cross linkable tyramine-modified MC conjugate which could be printed and showed good mechanical properties. In this study, reversible thermal cross linking was combined with photo crosslinking to form the hydrogel (Figure 9).…”

Section: Methylcellulosementioning

confidence: 99%

“…Schematic of the 3D bioprinting process via the dual crosslinking system (thermal and photo-cross linking) of Methylcellulose-Tyramine bioink. [86] Reproduced with permission. [86] Copyright 2020, Elsevier.…”

Section: Microbial Cellulosementioning

confidence: 99%

3D Bioprinting of Lignocellulosic Biomaterials

Shavandi

Hosseini

Okoro

et al. 2020

Adv Healthcare Materials

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The interest in bioprinting of sustainable biomaterials is rapidly growing, and lignocellulosic biomaterials have a unique role in this development. Lignocellulosic materials are biocompatible and possess tunable mechanical properties, and therefore promising for use in the field of 3D‐printed biomaterials. This review aims to spotlight the recent progress on the application of different lignocellulosic materials (cellulose, hemicellulose, and lignin) from various sources (wood, bacteria, and fungi) in different forms (including nanocrystals and nanofibers in 3D bioprinting). Their crystallinity, leading to water insolubility and the presence of suspended nanostructures, makes these polymers stand out among hydrogel‐forming biomaterials. These unique structures give rise to favorable properties such as high ink viscosity and strength and toughness of the final hydrogel, even when used at low concentrations. In this review, the application of lignocellulosic polymers with other components in inks is reported for 3D bioprinting and identified supercritical CO2 as a potential sterilization method for 3D‐printed cellulosic materials. This review also focuses on the areas of potential development by highlighting the opportunities and unmet challenges such as the need for standardization of the production, biocompatibility, and biodegradability of the cellulosic materials that underscore the direction of future research into the 3D biofabrication of cellulose‐based biomaterials.

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“…Furthermore, several other studies reported the use of SSE printing techniques to fabricate tablets [ 51 , 68 , 69 , 70 , 71 ], oral films [ 72 ], and scaffolds [ 73 ], illustrating that SSE is an excellent technique to fabricate thermosensitive drugs at a lower temperature.…”

Section: Resultsmentioning

confidence: 99%

3D Printing of Thermo-Sensitive Drugs

et al. 2021

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Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.

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Dual-crosslinked methylcellulose hydrogels for 3D bioprinting applications

Cited by 83 publications

References 45 publications

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

3D Bioprinting of Lignocellulosic Biomaterials

3D Printing of Thermo-Sensitive Drugs

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