Dual-Functional Iron Oxide Nanoparticles Coated with Polyvinyl Alcohol/5-Fluorouracil/Zinc-Aluminium-Layered Double Hydroxide for a Simultaneous Drug and Target Delivery System

Abstract

Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of Fe3O4 nanoparticles coated with a polymeric carrier and loaded with a 5-fluorouracil (5-FU) anti-cancer drug are discussed. The synthesized Fe3O4 nanoparticles were coated with polyvinyl alcohol and Zn/Al-layered double hydroxide as the drug host. The XRD, DTA/TG, and FTIR analyzes confirmed the presence of the coating layer on the surface of nanoparticles. The results showed a decrease in saturation magnetization of bare Fe3O4 nanoparticles after coating with the PVA/5FU/Zn/Al-LDH layer. In addition, the presence of the coating prevented the agglomeration of nanoparticles. Furthermore, the pseudo-second-order equation governed the kinetics of drug release. Finally, the coated nanoparticles showed stronger activity against liver cancer cells (HepG2) compared to that of the naked 5-FU drug, and displayed no cytotoxicity towards 3T3 fibroblast cell lines. The results of the present study demonstrate the potential of a nano delivery system for cancer treatment.

Iron-Based Magnetic Nanosystems for Diagnostic Imaging and Drug Delivery: Towards Transformative Biomedical Applications

“…Targeted drug delivery systems have used a variety of anti-cancer drug carriers, including magnetic iron oxide nanoparticles and natural biodegradable or non-biodegradable polymers [ 48 ]. The drugs can either be adsorbed on the surface of these carriers or enclosed inside of them and can be delivered to a given region using an external magnetic stimuli [ 49 , 50 , 51 , 52 ].…”

“…A polymer-magnetic composite consisting of poly( N -vinyl-2-pyrrolidone) and Fe 3 O 4 iron oxide ring-shaped nanostructure carrying doxorubicin have shown good in vivo tumour inhibition under magnetic hyperthermia [ 41 , 54 ]. Moreover, Zn-Al layered double hydroxide (LDH) nanosheets doped with Fe 3 O 4 MNPs carrying doxorubicin were found to be effective against HepG2 cancer cell line, according to a recent study [ 49 , 62 ]. This material was found to be pH responsive, with more acidic conditions resulting in a larger doxorubicin release profile, thus allowing scope for chemically triggered drug release.…”

Magnetic Nanoparticles Used in Oncology

“…Magnetic nanoparticles tend to form aggregates that are very important if the material is used as a contrast substance in magnetic resonance investigations [19][20][21]. MNPs also possess numerous advantages, such as a large surface area to volume ratio, pore sizes, functionalized surfaces, multiple sites for interaction or binding, and low mass transfer resistance, which makes them very suitable to be used in different disease treatments.…”

Polyaminoacid Based Core@shell Nanocarriers of 5-Fluorouracil: Synthesis, Properties and Theranostics Application

“…Therefore, it is essential to develop effective multifunctional 5-FU nanocarriers to improve targeted delivery, resulting in improved anticancer treatments. The following nanocarriers of 5-FU were proposed: polymer-based carriers such as chitosan beads, Eudragit ® , Poly(alkylcyanoacrylates), PLGA, β-cyclodextrin as well as liposomes, nanoemulsions, solid lipid nanoparticles, gold nanoparticles, silica nanocarriers, iron oxides nanoparticles, graphene oxides, and QD [24][25][26][27][28][29][30][31][32][33][34][35] The present contribution aimed to develop a novel method of preparing multifunctional 5-FU nanocarriers and their in vitro characterization. 5-FU polyaminoacid-based core@shell nanocarriers were formed by the encapsulation of drug-loaded nanocores with polyaminoacids multilayer shell via the layer-by-layer method with saturation technique.…”

“…Therefore, it is essential to develop effective multifunctional 5-FU nanocarriers to improve targeted delivery, resulting in improved anticancer treatments. The following nanocarriers of 5-FU were proposed: polymer-based carriers such as chitosan beads, Eudragit ® , Poly(alkylcyanoacrylates), PLGA, β-cyclodextrin as well as liposomes, nanoemulsions, solid lipid nanoparticles, gold nanoparticles, silica nanocarriers, iron oxides nanoparticles, graphene oxides, and QD [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]…”