Dual opposing actions of STW 5 on TRP receptors mediate neuronal desensitisation in vitro

Khalil, Mohammad; Zhang, Z.; Abdel-Aziz, H; Rabini, Sabine; Ammar, Ramy M.; Reeh, Peter W.; Engel, Matthias

doi:10.1016/j.lfs.2020.118112

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…Finally, an important mechanism of action of STW 5 is its anti-nociceptive property. As visceral hypersensitivity is a key pathogenic mechanism for pain in IBS, this anti-nociceptive effect likely contributes to the clinical efficacy of STW 5, with previous in vitro and in vivo laboratory investigations demonstrating the impact of STW 5 on gut hypersensitivity [5,[76][77][78][79][80][81].…”

Section: Discussionmentioning

confidence: 99%

Multi-target Treatment for Irritable Bowel Syndrome with STW 5: Pharmacological Modes of Action

Allescher

Burgell

Malfertheiner

et al. 2020

JGLD

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Irritable bowel syndrome (IBS) is a heterogeneous and complex functional gastrointestinal disorder with aglobal prevalence of approximately 11% and high geographic variation. IBS encompasses various symptomclusters considered to reflect complex patho-etiological mechanisms, and effective treatment options arelimited, with most medications targeting individual mechanisms and symptoms. Therefore, multi-targetedtreatment is required. IBS is currently viewed as a disorder of disturbed gut–brain interactions withabnormalities at different sites along the gut–brain axis, including altered gastrointestinal motility, visceralhypersensitivity, increased intestinal permeability, and altered gut microbiota. All of these abnormalitiesrepresent individual targets for STW 5, a herbal preparation with nine different extracts indicated for thetreatment of functional dyspepsia and IBS. As a multi-targeted medicinal drug, STW 5 possesses multiplepharmacodynamic effects. Several in vitro and in vivo studies have demonstrated STW 5 efficacy on numerousIBS patho-mechanisms targeting gastrointestinal smooth muscles, visceral afferent nerves, inflammation, gutpermeability, and the gut microbiome.

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Section: Discussionmentioning

confidence: 99%

Multi-target Treatment for Irritable Bowel Syndrome with STW 5: Pharmacological Modes of Action

Allescher

Burgell

Malfertheiner

et al. 2020

JGLD

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“…Furthermore, a gene database analysis of patients with irritable bowel syndrome (IBS) has found that TRPM8 is highly associated with IBS-C and IBS-M. 50 STW 5 and Menthacarin, two herbal drug combinations used for the treatment of visceral hypersensitivity in patients, have the effect to induce the desensitization of TRP channels in primary sensory neurons, peritoneal macrophages, and colonic organoids. 51 , 52 In addition, previous studies have also shown that TRPM8 agonists can ameliorate intestinal inflammation and reduce the protein levels of several inflammatory factors, such as tumor necrosis factor (TNF) -α, interleukin (IL) −1β, IL-6 and IL-12. 53 The knockout of TRPM8 aggravates the progression of colitis in mice model.…”

Section: Discussionmentioning

confidence: 99%

Global Trends and Hotspots of Transient Receptor Potential Melastatin 8 Research from 2002 to 2021: A Bibliometric Analysis

Zhang¹,

Kang²,

Yan³

et al. 2022

JPR

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Background Transient receptor potential channels are the major temperature and nociceptive receptors in the human body and transient receptor potential melastatin 8 (TRPM8) is the cold-sensitive and non-selective cation channel. In our study, we performed a bibliometric analysis of TRPM8 from 2002 to 2021 to summarize the current research status and potential research direction in the future. Methods The TRPM8-related publications were selected from the Web of Science Core Collection SCI-EXPANDED database from 2002 to 2021. The publication details, such as authors, titles, and author keywords, were used for bibliometric analysis and network visualization to present the current state of TRPM8 research. Results A total of 1035 articles met the inclusion criteria. The number of TRPM8-related articles has grown rapidly over the past two decades. The USA has the largest number of publications, citations, and international collaborations. The TRPM8-related articles are mainly published and cited in neurological journals, such as the Journal of Neuroscience (41 publications and 2171 local citations). Prevarskaya N. has the most publications (26), and Patapoutian A. has been cited the most (1414 local citations). The popular disciplines in TRPM8 research include Neurosciences and Neurology, Pharmacology and Pharmacy, Biochemistry, and Molecular Biology. Research hotspots are mainly TRP channel, calcium, prostate cancer, proliferation, pain, cold, nociception, and inflammation. Conclusion Our bibliometric analysis demonstrates that the number of TRPM8 studies has increased from 2002 to 2021. The global research trends and hotspots include the activation mechanism of TRPM8 in neurons, the role of TRPM8 in neuronal and non-neuronal diseases, and therapeutic target research.

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“…В экспериментальных исследованиях было обнаружено, что пероральное введение препарата Иберогаст® уменьшает афферентную чувствительность тонкой кишки к растяжению, а также внутривенному введению брадикинина и 5-гидрокситриптофана [30]. Недавно было показано, что Иберогаст® снижает висцеральную гиперчувствительность за счет десенситизации ионных каналов транзиторного рецепторного потенциала, что приводит к уменьшению выраженности таких симптомов, как боль в животе, ощущение вздутия, тошнота, раннее насыщение [31].…”

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Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review)

Маев

Трухманов

et al. 2022

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. To review the main mechanisms of functional disorders of the gastrointestinal tract and to present the materials of an Expert Council, which was held on 10 December 2021 in Moscow.Key points. The pathogenesis of the most common functional diseases of the gastrointestinal tract — functional dyspepsia (FD) and irritable bowel syndrome (IBS) is multifactorial and includes motor disorders of various parts of the gastrointestinal tract, visceral hypersensitivity, changes in the intestinal microbiome, impairment of the permeability of the protective barrier, low-grade inflammation of the gastrointestinal mucosa, etc. This often leads to the prescription of a complex of various medications to such patients, which increases the risk of undesirable drug interactions and side effects. Multitargeted therapy involves the use of drugs that simultaneously affect different pathogenetic links. One of these drugs is Iberogast®, which normalizes gastrointestinal motility and visceral sensitivity, has an anti-inflammatory action and is highly effective in treatment of FD and IBS.Conclusion. In the treatment of functional gastrointestinal diseases characterized by multifactorial pathogenesis, preference should be given to multi-targeted therapy with the use of drugs that have an effect on its various links.

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Dual opposing actions of STW 5 on TRP receptors mediate neuronal desensitisation in vitro

Cited by 8 publications

References 38 publications

Multi-target Treatment for Irritable Bowel Syndrome with STW 5: Pharmacological Modes of Action

Multi-target Treatment for Irritable Bowel Syndrome with STW 5: Pharmacological Modes of Action

Global Trends and Hotspots of Transient Receptor Potential Melastatin 8 Research from 2002 to 2021: A Bibliometric Analysis

Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review)

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