Dual photothermal nanocomposites for drug-resistant infectious wound management

Li, Changgui; Xian, Jiaru; Hong, Jixuan; Cao, Xiaxin; Zhang, Changze; Deng, Qiuju; Qin, Ziyu; Chen, Maohua; Zheng, Xiaofei; Li, Mengting; Hou, Jingwei; Zhou, Yinghong; Yin, Xijie

doi:10.1039/d2nr01998a

Cited by 9 publications

(3 citation statements)

References 70 publications

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“…For a wound healing dressing, it has certain antibacterial and even bactericidal properties to significantly reduce the chance of infection on the wound surface and promote the healing of the wound, especially the infected wound ( Liu et al, 2022a ; Li et al, 2022c ; Yu et al, 2022 ). Traditional wound care methods for infected wounds usually use antibiotics to solve the problem of wound infection, but a wide variety of bacterial species and complex environment on the wound surface make it difficult for a single antibiotic to cover all bacterial species, and long-term use of broad-spectrum antibiotics is easy to lead to the colonization and growth of multi-drug-resistant bacteria such as MRSA, further increasing the difficulty of wound healing ( Deurenberg and Stobberingh, 2008 ; Li et al, 2022c ). MXene has a lamellar structure similar to graphene and more abundant surface groups, so the researchers hypothesized that MXene should also have some antibacterial properties.…”

Section: Application Of Mxene and Its Modified Materials In Skin Woun...mentioning

confidence: 99%

Applications of MXene and its modified materials in skin wound repair

Zhang

Kong

et al. 2023

Front. Bioeng. Biotechnol.

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The rapid healing and repair of skin wounds has been receiving much clinical attention. Covering the wound with wound dressing to promote wound healing is currently the main treatment for skin wound repair. However, the performance of wound dressing prepared by a single material is limited and cannot meet the requirements of complex conditions for wound healing. MXene is a new two-dimensional material with electrical conductivity, antibacterial and photothermal properties and other physical and biological properties, which has a wide range of applications in the field of biomedicine. Based on the pathophysiological process of wound healing and the properties of ideal wound dressing, this review will introduce the preparation and modification methods of MXene, systematically summarize and review the application status and mechanism of MXene in skin wound healing, and provide guidance for subsequent researchers to further apply MXene in the design of skin wound dressing.

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Section: Application Of Mxene and Its Modified Materials In Skin Woun...mentioning

confidence: 99%

Applications of MXene and its modified materials in skin wound repair

Zhang

Kong

et al. 2023

Front. Bioeng. Biotechnol.

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“…BNC applications are vast (Lokhande et al, 2022;Rai and Dhar, 2022), but the combination of BNC with PDA has been less studied. The highly attractive properties of PDA considering its biocompatibility, biodegradability, and high photothermal conversion efficiency makes PDA-BNC membranes very useful to develop photothermal materials, for water treatment, and for wound healing by having antibacterial properties (Jiang et al, 2017;Jun et al, 2019;Li et al, 2022;Wahid et al, 2021).…”

Section: Preparation Of Pda-bncmentioning

confidence: 99%

Bacterial nanocellulose membrane as novel substrate for biomimetic structural color materials: Application to lysozyme sensing

Suleimenova

Frasco

Silva

et al. 2023

Biosensors and Bioelectronics: X

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“…Indeed, the in vitro and in vivo antibacterial efficacy of these nanocomposites was evaluated against S. aureus , E. coli , and MRSA. The results revealed an antibacterial efficacy of 99% under NIR irradiation at 808 nm (1.0 W/cm 2 ), an anti-inflammatory effect, and the regeneration of damaged tissue with a good biocompatibility evaluated by >85% of survival cells [ 57 ]. In another study, the photothermal efficiency of polydopamine nanoparticles was demonstrated in a construct of a gold nanostar/hollow polydopamine Janus nanostructure (GNS/HPDA JNPs).…”

Section: Ptt Combined With Metal or Metal Oxide Nanoparticles As Anti...mentioning

confidence: 99%

Photothermal/Photoacoustic Therapy Combined with Metal-Based Nanomaterials for the Treatment of Microbial Infections

Duval

2023

Microorganisms

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The increased spread and persistence of bacterial drug-resistant phenotypes remains a public health concern and has contributed significantly to the challenge of combating antibiotic resistance. Nanotechnology is considered an encouraging strategy in the fight against antibiotic-resistant bacterial infections; this new strategy should improve therapeutic efficacy and minimize side effects. Evidence has shown that various nanomaterials with antibacterial performance, such as metal-based nanoparticles (i.e., silver, gold, copper, and zinc oxide) have intrinsic antibacterial properties. These antibacterial agents, such as those made of metal oxides, carbon nanomaterials, and polymers, have been used not only to improve antibacterial efficacy but also to reduce bacterial drug resistance due to their interaction with bacteria and their photophysical properties. These nanostructures have been used as effective agents for photothermal therapy (PTT) and photodynamic therapy (PDT) to kill bacteria locally by heating or the controlled production of reactive oxygen species. Additionally, PTT or PDT therapies have also been combined with photoacoustic (PA) imaging to simultaneously improve treatment efficacy, safety, and accuracy. In this present review, we present, on the one hand, a summary of research highlighting the use of PTT-sensitive metallic nanomaterials for the treatment of bacterial and fungal infections, and, on the other hand, an overview of studies showing the PA-mediated theranostic functionality of metal-based nanomaterials.

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Dual photothermal nanocomposites for drug-resistant infectious wound management

Abstract: Management of antibiotic-resistant bacteria-induced skin infections for rapid healing remains a critical clinical challenge. Photothermal therapy, which uses mediated hyperthermia to combat such problems has recently been recognised as a...

Cited by 9 publications

References 70 publications

Applications of MXene and its modified materials in skin wound repair

Applications of MXene and its modified materials in skin wound repair

Bacterial nanocellulose membrane as novel substrate for biomimetic structural color materials: Application to lysozyme sensing

Photothermal/Photoacoustic Therapy Combined with Metal-Based Nanomaterials for the Treatment of Microbial Infections

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