Dual‐responsive reversible photo/thermogelling polymers exhibiting high modulus change

Dou, Qingqing; Liow, Sing Shy; Weng, Wengui; Loh, Xian Jun

doi:10.1002/pola.28191

Cited by 36 publications

(21 citation statements)

References 38 publications

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“…These drug‐loaded thermogels could effectively inhibit the growth of cancer cells. Besides, thermogelling polyurethanes based on PEG and PPG were synthesized with third component being a light‐responsive moiety such as aggregation‐induced emissive (AIE) molecule – tetraphenylethene (TPE) and spiropyran . Thermogels with TPE could be used as effective bioimaging probes.…”

Section: Types Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

“…On the other hand, thermogelling copolymer that consisted of spiropyran showed fast reversible gelation due to both light and temperature. This thermogel may find application as photo‐responsive sensor or anti‐counterfeiting material . Hydrogels formed via hydrophobic interaction, shown using the example of thermogels, possess many advantageous properties suitable for biomedical applications.…”

Section: Types Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

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A Recent Perspective on Noncovalently Formed Polymeric Hydrogels

Ke-min

Liow

Karim

et al. 2018

The Chemical Record

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Chemically crosslinked covalent hydrogels form a permanent and often strong network, and have been extensively used so far in drug delivery and tissue engineering. However, it is more difficult to induce dynamic and highly tunable changes in these hydrogels. Noncovalently formed hydrogels show promise as inherently reversible systems with an ability to change in response to dynamic environments, and have garnered strong interest recently. In this Personal Account, we elucidate a few key attractive properties of noncovalent hydrogels and describe recent developments in hydrogels crosslinked using various different noncovalent interactions. These hydrogels offer huge control for modulating material properties and could be more relevant mimics for biological systems.

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Section: Types Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

Section: Types Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

A Recent Perspective on Noncovalently Formed Polymeric Hydrogels

Ke-min

Liow

Karim

et al. 2018

The Chemical Record

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“…22 Furthermore, PEG-PPG-spiropyran block copolymer system, denoted as EPS, has also been reported to exhibit light- and temperature-sensitive reversible gelation. 23 As extensively demonstrated in aforementioned cases, providing dual-stimuli sensitivity to hydrogel systems has significantly broadened the scope of potential applications.…”

Section: Introductionmentioning

confidence: 95%

Pluronic‐based dual‐stimuli sensitive polymers capable of thermal gelation and pH‐dependent degradation for in situ biomedical application

Whang

Lee

Kundu

et al. 2018

J of Applied Polymer Sci

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Thermo-sensitive hydrogels are considered ideal for applications in the biomedical fields for their biocompatibility, flexibility, tissue-like water content, and reversible gelation property. By adjusting sufficient hydrophilic-hydrophobic balance in block copolymer structure, thermogel's critical gelation temperature can be modified to be near the physiological temperature, which makes it an appealing candidate for in situ gel depot. In this study, we report successful syntheses of novel multiple block copolymer compounds, denoted as dual-stimuli sensitive polymers (DSSPs), by copolymerizing Pluronic® P104 (7,100 Da) and 2,2-bis(aminoethoxy)propane (BAP) using diisocyanate linkers, L-lysine ethyl ester diisocyanate (DSSP-1) and 1,6-hexamethylene diisocyanate (DSSP-2). Through effective elongation of polymer chain lengths (DSSP-1: 41,760 Da, DSSP-2: 41,230 Da), Pluronic® P104's reversible thermal gelation properties were enhanced, as demonstrated by lowered critical gelation temperatures (DSSP-1: 36°C, DSSP-2: 38.7°C; 15 wt.%) that is near the physiological temperature. Furthermore, integration of acid-labile BAP allowed rapid pH-dependent degradation of the polymer, which was displayed by gel permeation chromatography (GPC) and release profiles of nile red and irinotecan from polymeric micelles and gels, respectively.

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“…Here, we propose a porous ALG-PAAm hydrogel with controllable pore size using a top-down method. EPS, a spiropyran-based light responsive polymer developed by our group recently, 33 is used as a templating agent. When exposed to an incident wavelength of 535 nm, EPS chains collapse and undergo a reversible sol-gel transition.…”

Section: Introductionmentioning

confidence: 99%