Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia

Gargala, Gilles; Lecleire, Stéphane; François, Arnaud; Jacquot, Serge; Déchelotte, Pierre; Ballet, J.; Favennec, Loïc; Ducrotté, Philippe

doi:10.3748/wjg.v13.i16.2333

Cited by 36 publications

(27 citation statements)

References 51 publications

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“…In contrast to Walker et al, 34 Gargala et al found no differences between duodenal IEL counts of H. pylori negative, functionally dyspeptic adults and controls. 36 One study conducted on children with functional dyspepsia 37 also noted differences in duodenal mast cell densities but not in IEL counts. In summary, although a theoretical influence of a functional gastrointestinal disorder on the presence of intestinal inflammatory cells might be argued, available studies are insufficient at this point to support an association with duodenal IELs.…”

Section: Discussionmentioning

confidence: 99%

Duodenal intraepithelial lymphocytosis is common in children without coeliac disease, and is not meaningfully influenced by Helicobacter pylori infection

Guz‐Mark

Zevit

Morgenstern

et al. 2014

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Duodenal intraepithelial lymphocytosis is common in children without coeliac disease, and is not meaningfully influenced by Helicobacter pylori infection

Guz‐Mark

Zevit

Morgenstern

et al. 2014

Aliment Pharmacol Ther

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“…In addition, Gargala et al54 reported that the number of intraepithelial lymphocytes in the duodenal mucosa was significantly greater in H. pylori -positive FD patients than in healthy controls, but not different between H. pylori -negative FD patients and healthy controls. The expressions of CD95/Fas and HLA-DR-expressing CD3 + lymphocytes were lower in H. pylori -negative FD patients than in healthy controls.…”

Section: Duodenum - a Crossroad Between Helicobacter Pylori And Dyspementioning

confidence: 99%

What Is the Difference Between -Associated Dyspepsia and Functional Dyspepsia?

Suzuki

Matsuzaki²,

Hibi³

2011

J Neurogastroenterol Motil

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Advances in basic and clinical research have revealed that Helicobacter pylori (H. pylori) infection plays an important role in the development of gastroduodenal dysmotility and hypersensitivity, as also in dyspepsia symptoms. In addition, recent studies have proposed an inflammation-immunological model for the pathogenesis of functional dyspepsia. Since H. pylori is the major microbe that provokes a gastroduodenal inflammatory response, it should not be overlooked when considering the pathophysiology of dyspepsia symptoms. In fact, population-based studies have demonstrated that H. pylori is detected more frequently in dyspepsia patients. However, although many clinical studies tried to reveal the association of H. pylori infection with gastric motility dysfunction or hypersensitivity, the results have been conflicting. On the other hand, many etiological features were revealed for the development of H. pylori-associated dyspepsia, such as abnormal ghrelin or leptic secretion, altered expression of muscle-specific microRNAs, and duodenal inflammatory cell infiltration. In addition, therapeutic strategy for H. pylori-associated dyspepsia would be different from H. pylori-negative functional dyspepsia. This review focuses the issue of whether H. pylori-associated dyspepsia should be considered as a different disease entity from functional dyspepsia.

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“…Early satiety, weight loss, nausea and vomiting are more frequently reported in patients with presumed PI-FD 53 . Helicobacter pylori ( H. pylori ) infection, gastric emptying, and gastric sensitivity do not seem to be associated with PI-FD, whereas a high prevalence of impaired gastric accommodation is observed in patients with presumed PI-FD 54. This impairment is suggested to be attributable to a dysfunction at the level of gastric nitrergic neurons.…”

Section: Duodenal Immune Activation In Fdmentioning

confidence: 99%

Duodenal Implications in the Pathophysiology of Functional Dyspepsia

Lee¹,

Tack²

2010

J Neurogastroenterol Motil

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Functional dyspepsia (FD) is a heterogeneous disorder associated with diverse pathophysiologic mechanisms. Studies have shown duodenal implications in the pathophysiology of FD. Duodenal hypersensitivity to acid, increased duodenal acid exposure, and abnormal responses to duodenal lipids or released cholecystokinin have been observed in patients with FD. Moreover, there is evidence indicating duodenal immune activation in FD. Alterations in the number of duodenal eosinophils or intraepithelial lymphocytes have been reported in a subset of FD patients, particularly in patients with post-infectious FD. Whether these abnormalities in the duodenum play a crucial role in the generation of dyspeptic symptoms needs to be elucidated. Further investigations on the relationship between duodenal abnormalities and well-known pathophysiologic mechanisms of FD are required. Furthermore, the causative factors related to the development of duodenal abnormalities in FD warrant further study.

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Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia

Abstract: In H pylori negative FD patients, the phenotypic characterization of IELs suggests that we cannot exclude a role of IELs in FD.

Cited by 36 publications

References 51 publications

Duodenal intraepithelial lymphocytosis is common in children without coeliac disease, and is not meaningfully influenced by Helicobacter pylori infection

Duodenal intraepithelial lymphocytosis is common in children without coeliac disease, and is not meaningfully influenced by Helicobacter pylori infection

What Is the Difference Between -Associated Dyspepsia and Functional Dyspepsia?

Duodenal Implications in the Pathophysiology of Functional Dyspepsia

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