Duration of gestation in pregnant dogs carrying cloned fetuses

Kim, Min Jung; Oh, Hyun Ju; Park, Jung Eun; Park, Eun Jung; Jo, Yeonhwa; Lee, Byeong Chun

doi:10.1016/j.theriogenology.2012.08.011

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…The slightly higher birth weights of cloned working dogs (Labrador Retriever, n = 23, 500 g; German Shepherd, n = 11, 560 g; Springer Spaniel, n = 9, 600 g; Belgian Malinois, n = 4, 580 g; Fig. 1 , unpublished data) compared to those of dogs produced naturally [ 16 ] might be due to the lower average litter size in pregnancies derived by transfer of cloned embryos compared to pregnancies produced by artificial insemination [ 34 ]; regardless, the cloned dogs showed normal growth patterns. Park et al [ 45 ] also reported that growth profiles, as assessed by body weight and height, of three cloned Afghan hounds were similar to that of their cell donor.…”

Section: Healthy Development Of Cloned Dogsmentioning

confidence: 99%

“…Although all cloned dogs derived from an elite working dog can qualify as a working dog, the low efficiency of SCNT-based cloning could be a hurdle when propagating qualified working dogs. There have been efforts to improve dog cloning efficiency by applying mineral treatments to oocyte-donor dogs [ 33 ], as well as through acetylation [ 32 ] or synchronization of donor cells [ 43 ], replacement of primary culture media [ 28 ] or post-activation media [ 42 ], and by establishing a monitoring method during parturition [ 34 ]. However, the pregnancy rate (number of pregnant dogs divided by the number of recipients) and delivery rate (number of pups divided by number of embryos transferred) have been reported as 12.5% to 28.6% and 1.7% to 3.8% ( Table 2 ), respectively, which are deemed unsatisfactory.…”

Section: Concerns About Dog Cloningmentioning

confidence: 99%

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Health and temperaments of cloned working dogs

Kim

Hwang³

et al. 2018

J Vet Sci

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Dogs serve human society in various ways by working at tasks that are based on their superior olfactory sensitivity. However, it has been reported that only about half of all trained dogs may qualify as working dogs through conventional breeding management because proper temperament and health are needed in addition to their innate scent detection ability. To overcome this low efficiency of breeding qualified working dogs, and to reduce the enormous costs of maintaining unqualified dogs, somatic cell nuclear transfer has been applied in the propagation of working dogs. Herein, we review the history of cloning working dogs and evaluate the health development, temperaments, and behavioral similarities among the cloned dogs. We also discuss concerns about dog cloning including those related to birth defects, lifespan, and cloning efficiency.

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Section: Healthy Development Of Cloned Dogsmentioning

confidence: 99%

Section: Concerns About Dog Cloningmentioning

confidence: 99%

Health and temperaments of cloned working dogs

Kim

Hwang³

et al. 2018

J Vet Sci

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“…Pregnancy diagnosis was performed 26 days after embryo transfer by ultrasound using a SONOACE 9900 (Medison, Seoul, Korea) ultrasound scanner with 7.0 MHz linear-array probe. The number of fetuses was confirmed 45 days after the embryo transfer, and pregnancy was monitored as previously described until parturition 23 .…”

Section: Methodsmentioning

confidence: 99%

Birth of clones of the world’s first cloned dog

Kim

Setyawan

et al. 2017

Sci Rep

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Animal cloning has gained popularity as a method to produce genetically identical animals or superior animals for research or industrial uses. However, the long-standing question of whether a cloned animal undergoes an accelerated aging process is yet to be answered. As a step towards answering this question, we compared longevity and health of Snuppy, the world’s first cloned dog, and its somatic cell donor, Tai, a male Afghan hound. Briefly, both Snuppy and Tai were generally healthy until both developed cancer to which they succumbed at the ages of 10 and 12 years, respectively. The longevity of both the donor and the cloned dog was close to the median lifespan of Afghan hounds which is reported to be 11.9 years. Here, we report creation of 4 clones using adipose-derived mesenchymal stem cells from Snuppy as donor cells. Clinical and molecular follow-up of these reclones over their lives will provide us with a unique opportunity to study the health and longevity of cloned animals compared with their cell donors.

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“…Then, the cloned embryos were surgically transferred into one oviduct of a naturally synchronized recipient dog. Pregnancy diagnosis was performed at least 28 days after the embryo transfer by ultrasonography, and serum progesterone concentration, rectal temperature, and fetal heartbeat were monitored for safe delivery [37].…”

Section: Production Of a Cloned Dogmentioning

confidence: 99%