Ectopic liver and gallbladder in a cloned dog: Possible nonheritable anomaly

Health and temperaments of cloned working dogs

“…However, in cloned dogs, features related to large offspring syndrome have been rarely reported with the exception of an increased placental weight [ 43 ]. Other perinatal abnormalities of cloned dogs have been reported [ 29 30 ], but the specific causes of these defects remain incompletely described. At present, reports on the lifespans and age-related diseases of cloned animals are rare, even though it has been almost 20 years since the first cloned mammals were produced.…”

“…Artificial activation of the reconstructed embryos was induced, and, immediately after activation, the embryos were transferred into oviducts of recipient dogs. Consequently, the resulting cloned puppy had the same nuclear and mitochondrial genetic information as the cell donor and oocyte donor, respectively [ 8 29 37 42 ]. Since that first cloned dog, a variety of cloned dogs have been produced, and it has been reported that dog cloning using the SCNT technique can be successfully performed regardless of the sex (male [ 36 ] and female [ 25 ]), age (fetus [ 18 ], young adult [ 36 ], and old [ 24 ]), or breed (Afghan hound [ 25 36 ], miniature poodle [ 24 ], beagle [ 18 29 ], Labrador Retriever [ 35 43 ], Pekingese [ 46 ], German Shepherd [ 30 42 ], Sapsaree [ 23 ], and Gyeongju Donggyeong dog [ 8 ]) of the cell donor.…”