Dust and Collagen Content of Lungs of Coal-Workers with Progressive Massive Fibrosis

Nagelschmidt, G.; Rivers, Desiree; King, E. J.; Trevella, Wendy

doi:10.1136/oem.20.3.181

Cited by 23 publications

(20 citation statements)

References 16 publications

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“…13,14 In contrast, silica likely contributes to the development of PMF in some workers 15 but is not required in others. 16 Although the radiographic appearances of silicosis and CWP are similar, the 2 processes differ pathologically. CWP is characterized histologically by aggregates of coal dust and fibroblasts, which comprise the coal macule.…”

Section: Coal Worker's Pneumoconiosismentioning

confidence: 98%

Occupational Lung Disease

Sirajuddin

Kanne

2009

Journal of Thoracic Imaging

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Despite federally mandated safety standards, occupational lung disease remains one of the most common work-related injuries. Inhaled dust can result in a range of tissue injury in the lung and can lead to significant respiratory insufficiency causing death. Although silicosis and coal worker's pneumoconiosis are becoming less common, hypersensitivity pneumonitis is increasingly recognized as an occupational lung disease with new antigens being introduced annually. Imaging, particularly high-resolution computed tomography, is central to the management of occupational lung disease and is useful in diagnosis, assessment of disease activity, and evaluating response to therapy.

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Section: Coal Worker's Pneumoconiosismentioning

confidence: 98%

Occupational Lung Disease

Sirajuddin

Kanne

2009

Journal of Thoracic Imaging

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“…The experiments were conducted in three separate cubical dust rooms, 8ft in dimension (512 ft 3 ). Animals were placed in these rooms at the beginning of each experiment and remained there 24 hr per day until killed for examination.…”

Section: Methodsmentioning

confidence: 99%

Lung Dust Content and Response in Guinea Pigs Inhaling Three Forms of Silica

Pratt

1983

Archives of Environmental Health: An International Journal

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Guinea pigs were exposed by inhalation to atmospheric suspensions of crystalline free silica (cristobalite), amorphous free silica (diatomaceous earth), and amorphous silicate (volcanic glass). Randomly selected animals were killed at 2-month intervals and their lungs were examined. Tissue samples were collected and analyzed for total silica content and total ash. Total silica content per lung increased linearly throughout at least 21 months in each experiment and total ash weight increased more rapidly than dust was accumulating. Crystalline silica produced a greater increment in ash weight that did the amorphous free silica and the silicate produced the least increase. Furthermore, although atmospheric dust concentrations were roughly comparable for the three preparations, the total amount of silica accumulated varied inversely with the degree of tissue damage occurring. Thus, the maximum total content of the crystalline silica reached only 68 mg per lung, while that of the amorphous silica and silicate was 120 mg and 465 mg, respectively. This suggests that a silicious dust that produces cell damage may be cleared more effectively from the lung than is an innocuous dust.

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“…Quartz content averaged 2.8% of total lung dust, with a range of 0.5 to 10.5%, although the highest level did not lead to a specifically silicotic response, and the proportions of coal and quartz exhibited no constancy. Later analyses included material from other coal fields and separated simple from complicated disease by excising the lesions of massive fibrosis (18). Although the concentration of dust in PMF was approximately double that in the rest of the lung affected by simple disease, the dust composition remained similar.…”

Section: Human Responsesmentioning

confidence: 99%

“…The overlap was also apparent in later material, so much so that for a particular dust burden lungs displayed widely divergent pathological features (21,22 (18). From the lungs of certain coal workers with PMF no quartz could be recovered (39).…”

Section: Human Responsesmentioning

confidence: 99%

Prevalence and pathogenesis of pneumoconiosis in coal workers.

Heppleston

1988

Environ Health Perspect

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Dust dose and composition do not appear to account wholly for changes in the prevalence of coal workers' pneumoconiosis in Europe. In certain coal pits high progression evidently occurred with relatively low dust exposure or vice versa, whereas progression in relation to dust levels might be variable. Exceptionally high quartz concentrations occur in coal mine dust when pneumoconiosis may progress with unusual rapidity. Under such circumstances lesions resembling silicotic nodules may be found, but with the customarily lower levels of quartz the pathological features assume the form characteristic of coal workers. Morphological changes in relation to dust content of human and animal lungs, as well as cellular behavior, have not accounted completely for the epidemiological findings. Considering all the pathological evidence helps explain the pathogenesis of pneumoconiosis and vagaries of progression. The origin of progressive massive fibrosis cannot be explained simply in terms of dust burden or immunological features, and the role of an infective factor cannot be dismissed. Moreover, lipid secretion by alveolar epithelium introduces a new element that could affect the development of simple and complicated pneumoconiosis. In vitro, cytotoxicity appeared to be too variable for predictive purposes, though direct assay of fibrogenicity using the macrophage fibrogenic factor suggested that dust dose was more important than dust composition. Assessing individual susceptibility presents serious obstacles.

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Dust and Collagen Content of Lungs of Coal-Workers with Progressive Massive Fibrosis

Cited by 23 publications

References 16 publications

Occupational Lung Disease

Occupational Lung Disease

Lung Dust Content and Response in Guinea Pigs Inhaling Three Forms of Silica

Prevalence and pathogenesis of pneumoconiosis in coal workers.

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