Dye Loading of Amphiphilic Poly(organosiloxane) Nanoparticles

Abstract

The loading of amphiphilic poly(organosiloxane) nanoparticles with hydrophilic dyes in organic solvents depends inter alia on the construction of the nanoparticles (core-shell, hollow spheres), on the amphiphilicity, is adjustable by synthesis, and on the method of the phase transfer. For more information see the Communication by M. Maskos et al. on the following pages.

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

“…In contrast, SiNPs with thinner shells containing dyes closer to the particle surface are more mobile, thus can exhibit a decrease of the fluorescence yield. This method to prepare the well-defined SiNPs is much simpler than the preparation of micelles from dye-labeled block copolymers or other nanosized tracers with a core-shell topology in which dyes were loaded through the diffusion [380]. Moreover, the major disadvantage of dye-labeled tracers with labels attached directly to the particle surface would allow dyes to escape by a simple diffusion, thus the synthesis of particles with core-shell topology according with Van Blaaderen method allowed to minimize such effects [372].…”

Multifunctional, multicompartment polyorganosiloxane magnetic nanoparticles for biomedical applications

“…The particles have been characterized by AF-FFF, TEM, SQUID and Mö ssbauer spectroscopy. As shown previously, the polyorganosiloxane nanospheres can be used as nanocontainers and nanoreactors [9,16], allowing potential incorporation of different functionalities in the future. In addition, the surface of the polyorganosiloxane can be modified by grafting with, for example, poly(ethylene oxide) to make the nanospheres water dispersable.…”

“…We report on the synthesis and characterization of magNPs and their incorporation in polyorganosiloxane core-shell nanospheres. Such nanospheres are nanonetworks where the interior can be accessed, for example by diffusion and, therefore, can be filled with appropriate small molecules [9]. For potential biomedical applications in aqueous solutions, the surface of the nanospheres can be modified by grafting end-functionalized poly(ethylene oxide), as shown before [10].…”

Generalization of in-situ polymerization method for preparing core-shell polymeric nanospheres and hollow spheres

“…The "layer-by-layer (LBL)" technique via alternative deposition of oppositely charged polyelectrolytes on latex particles [8−9], "in-situ" polymerization on the templates of organic nanoparticles or vesicles [10−13], and micro-or miniemulsion polymerization [14−18] all can be used to fabricate hollow spheres. Recently, some new approaches to the hollow spheres have been reported: assembly of amphiphilic graft copolymers at the water-oil interface [19], assembly of silica and gold nanoparticles cooperatively with block copolypeptides [20], "in-situ" polymerization of acrylic acid in the presence of chitosan [21], formation of core-shell nanoparticles based on polycondensation of organosilanes and subsequent removal of the non-bonded chains from the core [22].…”