Background: Post-cholecystectomy syndrome (PCS) is a group of heterogeneous signs and symptoms, predominately consisting of right upper quadrant abdominal pain, dyspepsia, and/or jaundice, manifesting after undergoing a cholecystectomy. According to some studies, as many as 40% of post-cholecystectomy patients are in fact, affected by this syndrome. This study aims to determine the demographics, aetiology, average length of hospital stay, and health care burden associated with PCS.Methods: We queried the National Inpatient Sample (NIS) database to determine inpatient admissions of post-cholecystectomy syndrome between 2011 and 2014 using the ICD-9 primary diagnosis code 576.0.