Dynamic hydrogels mediated by macrocyclic host–guest interactions

Xiao, Tangxin; Xu, Lixiang; Zhou, Ling; Sun, Xiaoqiang; Chen, Lin; Wang, Leyong

doi:10.1039/c8tb02339e

Cited by 96 publications

(60 citation statements)

References 119 publications

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“…Host–guest chemistry is widely considered a landmark of supramolecular chemistry and focuses on uses of non-covalent interactions to hold together multicomponent molecular aggregates (Steed and Atwood, 2013; Xiao et al, 2019a,b). In the context of crystal engineering, hosts that provide the ability to confine guests into channel-type architectures have received increased attention due to intriguing properties (e.g., catalysis Yang et al, 2006, dynamics Wu et al, 2019, photoconduction Quintel and Hulliger, 1999, sorption Lim et al, 2008, and separation Chen et al, 2013; Barton et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Channel Confinement of Aromatic Petrochemicals via Aryl–Perfluoroaryl Interactions With a B←N Host

et al. 2019

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We report channel confinement properties of an electron-deficient boron host derived from the orthogonal B←N interaction between a boronic ester and trans-pentafluorostilbazole. The boron host forms one-dimensional channels in the crystalline solid state when crystallized with common electron-rich aromatic petrochemicals (i.e., benzene, toluene, o-xylene) to form solvates and a cocrystal with stilbene. Molecular confinement of the electron-rich molecules in the solids is achieved through a combination of aryl–perfluoroaryl interactions (π-πF) and hydrogen bonds.

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Section: Introductionmentioning

confidence: 99%

Channel Confinement of Aromatic Petrochemicals via Aryl–Perfluoroaryl Interactions With a B←N Host

et al. 2019

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“…These hydrogels have great application potential in the fields of biomedical materials, self-repairing materials, and intelligent materials. However, the formation mechanism of dynamic hydrogel still must be further studied, and as a biomedical application, hydrogel needs more extensive research in biocompatibility and cytotoxicity testing (Xiao et al, 2019b ). In addition, the poor mechanical stability (Hoffman, 2012 ) and rapid drug release of hydrogels (Brandl et al, 2010 ) limit their development.…”

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Zhang

Cheng

et al. 2020

Front. Chem.

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Polyphenol, characterized by various phenolic rings in the chemical structure and an abundance in nature, can be extracted from vegetables, grains, chocolates, fruits, tea, legumes, and seeds, among other sources. Tannic acid (TA), a classical polyphenol with a specific chemical structure, has been widely used in biomedicine because of its outstanding biocompatibility and antibacterial and antioxidant properties. TA has tunable interactions with various materials that are widely distributed in the body, such as proteins, polysaccharides, and glycoproteins, through multimodes including hydrogen bonding, hydrophobic interactions, and charge interactions, assisting TA as important building blocks in the supramolecular self-assembled materials. This review summarizes the recent immense progress in supramolecular self-assembled materials using TA as building blocks to generate different materials such as hydrogels, nanoparticles/microparticles, hollow capsules, and coating films, with enormous potential medical applications including drug delivery, tumor diagnosis and treatment, bone tissue engineering, biofunctional membrane material, and the treatment of certain diseases. Furthermore, we discuss the challenges and developmental prospects of supramolecular self-assembly nanomaterials based on TA.

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“…[1] Many hydrogels are either polymers of natural origin [2] (such as polysaccharides, [3] nucleic acids, [4] or proteins [2b,f, 5] )o rm an-made polymers crosslinked by covalent bridges (e.g. polyacrylamide or polyacrylates bridged by bisacrylamide, [6] disulfides, [7] boronate ester/diol linkers [8] or supramolecular complexes composed of hydrogen bonds, [9] metal-ligand complexes, [10] or host-guest interactions, [11] and more [12] ). Many different applications of hydrogels have been suggested, including their use as separation matrices, [13] carriers of enzymes for biotechnological transformations, [14] and biomedical applications, [4e, 15] such as tissue engineering, [2g,10c, 16] bone regeneration, [17] drug delivery, [3h,18] immunotherapy, [19] and biosensing.…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐Responsive Biomolecule‐Based Hydrogels and Their Applications

2020

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This Review presents polysaccharides, oligosaccharides, nucleic acids, peptides, and proteins as functional stimuli‐responsive polymer scaffolds that yield hydrogels with controlled stiffness. Different physical or chemical triggers can be used to structurally reconfigure the crosslinking units and control the stiffness of the hydrogels. The integration of stimuli‐responsive supramolecular complexes and stimuli‐responsive biomolecular units as crosslinkers leads to hybrid hydrogels undergoing reversible triggered transitions across different stiffness states. Different applications of stimuli‐responsive biomolecule‐based hydrogels are discussed. The assembly of stimuli‐responsive biomolecule‐based hydrogel films on surfaces and their applications are discussed. The coating of drug‐loaded nanoparticles with stimuli‐responsive hydrogels for controlled drug release is also presented.

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Dynamic hydrogels mediated by macrocyclic host–guest interactions

Abstract: The recent progress in dynamic hydrogels mediated by macrocyclic host–guest interactions is reviewed.

Cited by 96 publications

References 119 publications

Channel Confinement of Aromatic Petrochemicals via Aryl–Perfluoroaryl Interactions With a B←N Host

Channel Confinement of Aromatic Petrochemicals via Aryl–Perfluoroaryl Interactions With a B←N Host

Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Stimuli‐Responsive Biomolecule‐Based Hydrogels and Their Applications

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