Dynamic mechanical properties and in vitro bioactivity of PHBHV/HA nanocomposite

Chen, D. Z.; Tang, Chak Yin; Chan, Kang Cheung; Tsui, Chi Pong; Yu, Peter H.; Leung, Mason C.P.; Uskoković, Dragan

doi:10.1016/j.compscitech.2006.07.034

Cited by 123 publications

(53 citation statements)

References 54 publications

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“…Both bioactivity and mechanical properties of these biocomposites can be tailored by varying the volume percentage of calcium orthophosphates. Similarly, biocomposites of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV) with both HA and amorphous carbonated apatite (almost ACP) appeared to have a promising potential for repair and replacement of damaged bones [346][347][348][349].…”

Section: Apatite-based Biocompositesmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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Section: Apatite-based Biocompositesmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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“…Similarly, biocomposites of PHBHV with both HA and amorphous carbonated apatite (almost ACP) appeared to have promising potential for repair and replacement of damaged bones. [416][417][418][419] Along these lines, PCL is used as a slowly biodegradable but good biocompatible polymer. PCL/HA and PCL/CDHA biocomposites have already been discussed as suitable materials for substitution, regeneration and repair of bone tissues.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

156

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“…Chen et al observed the same trend as he added nano-hidroxyapatite (nHA) to a P(HB-12%HV) matrix. They claimed that well distributed nHA catalyzed the polymer decomposition and obstructed the degradation by-products to diffuse out of the sample 25 . TGA was also used to determine the content and distribution of ND in the microcapsules.…”

Section: Resultsmentioning

confidence: 99%

Thermo-Mechanical Properties of P(HB-HV) Nanocomposites Reinforced by Nanodiamonds

et al. 2017

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Several studies of biodegradable polymers and copolymers have been carried for different applications in the biomedical area. This current study aims to develop a biocomposite to be used as an orthopedic device, using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) P(HB-HV), a biodegradable copolymer, with 94%HB and 6%HV, as matrix; and nanodiamonds (ND) with primary grains of 4-6nm, as reinforcement. The nanodiamonds were previously encapsulated by P(HB-HV) and specimens were prepared using a hydraulic press and injection molding machine, in order to evaluate which method presents a better performance. Thermal and mechanical analyses were done to compare their behavior. The biocomposite and pure P(HB-HV) samples were analyzed by flexural testing, nanoidentation, DMA, XRD, TGA. The distribution of nanodiamonds on the specimen fracture surface were investigated by SEM. The SEM micrographs allowed us to concluded that the encapsulation of nanodiamonds by P(HB-HV) was successfully performed, promoting a better interface and distribution in the polymeric matrix. The presence of ND in the polymeric matrix decreased the P(HB-HV) crystallinity, inhibiting the crystallite growth. The mechanical properties obtained from flexural test, nanoidentation and DMA of the injection-molded specimens were superior to compression-molded, due to its homogeneous and continuous structure. In vitro analysis was performed to evaluate the samples cytoxicity.

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Dynamic mechanical properties and in vitro bioactivity of PHBHV/HA nanocomposite

Cited by 123 publications

References 54 publications

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Thermo-Mechanical Properties of P(HB-HV) Nanocomposites Reinforced by Nanodiamonds

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