Dynamic responses of the haematopoietic stem cell niche to diverse stresses

Batsivari, Antoniana; Haltalli, Myriam; Passaro, Diana; Pospori, C; Celso, Cristina Lo; Bonnet, Dominique

doi:10.1038/s41556-019-0444-9

Cited by 104 publications

(99 citation statements)

References 177 publications

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“…( 7,8 ) Vascular cells have also been identified to be part of niches that control the maintenance and functions of hematopoietic stem cells (HSCs) and derived hematopoietic progenitors in the bone. ( 4,9 ) Overall, blood vessels play a critical role in regulating specialized microenvironments that are directly associated with the bone and blood physiology.…”

Section: Introductionmentioning

confidence: 99%

Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

Chen

Hendriks

Chatzis

et al. 2020

Journal of Bone and Mineral Research

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Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete angiocrine factors required for the survival, maintenance, and self-renewal of stem and progenitor cells. In the skeletal system, vasculature creates nurturing niches for bone and blood-forming stem cells. Blood vessels regulate hematopoiesis and drive bone formation during development, repair, and regeneration. Dysfunctional vascular niches induce skeletal aging, bone diseases, and hematological disorders. Recent cellular and molecular characterization of the bone marrow microenvironment has provided unprecedented insights into the complexity, heterogeneity, and functions of the bone vasculature and vascular niches. The bone vasculature is composed of distinct vessel subtypes that differentially regulate osteogenesis, hematopoiesis, and disease conditions in bones. Further, bone marrow vascular niches supporting stem cells are often complex microenvironments involving multiple different cell populations and vessel subtypes. This review provides an overview of the emerging vascular cell heterogeneity in bone and the new roles of the bone vasculature and associated vascular niches in health and disease.

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Section: Introductionmentioning

confidence: 99%

Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

Chen

Hendriks

Chatzis

et al. 2020

Journal of Bone and Mineral Research

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“…While intrinsic factors appear to be important to the inflammatory response involved in the pathogenesis of CHIP-associated diseases, extrinsic mechanisms may also influence this process as the conditioned media from aged mesenchymal stromal cells impairs the function of young HSCs [ 117 ]. In addition to acting directly on HSCs, inflammation can also remodel the bone marrow microenvironment, which regulates hematopoiesis [ 118 ]. Additional studies are needed to understand the ways in which these pathways are altered during aging and pathogenesis, and how they may be modified for health benefit.…”

Section: C) Age-related Clonal Hematopoiesis Of Indeterminant Potentimentioning

confidence: 99%

Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?

Broxmeyer

Liu

Kapur

et al. 2020

Stem Cell Rev and Rep

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There is an ongoing shift in demographics such that older persons will outnumber young persons in the coming years, and with it age-associated tissue attrition and increased diseases and disorders. There has been increased information on the association of the aging process with dysregulation of hematopoietic stem (HSC) and progenitor (HPC) cells, and hematopoiesis. This review provides an extensive up-to date summary on the literature of aged hematopoiesis and HSCs placed in context of potential artifacts of the collection and processing procedure, that may not be totally representative of the status of HSCs in their in vivo bone marrow microenvironment, and what the implications of this are for understanding aged hematopoiesis. This review covers a number of interactive areas, many of which have not been adequately explored. There are still many unknowns and mechanistic insights to be elucidated to better understand effects of aging on the hematopoietic system, efforts that will take multidisciplinary approaches, and that could lead to means to ameliorate at least some of the dysregulation of HSCs and HPCs associated with the aging process. Graphical Abstract

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“…Of note, APLN + endothelial cells showed high similarities to the Ly6a high subpopulation of endothelial cells described by Tikhonova AN et al [ 4 , 49 ]. A detailed review characterizing the BM microenvironment and its response to hematopoietic stress (e.g., inflammation, irradiation, malignancy and chemotherapy) has previously been published [ 50 ].…”

Section: Niche Alterations In Disease and Hematopoietic Stressmentioning

confidence: 99%

The Bone’s Role in Myeloid Neoplasia

Kazianka

Staber

2020

IJMS

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The interaction of hematopoietic stem and progenitor cells with their direct neighboring cells in the bone marrow (the so called hematopoietic niche) evolves as a key principle for understanding physiological and malignant hematopoiesis. Significant progress in this matter has recently been achieved making use of emerging high-throughput techniques that allow characterization of the bone marrow microenvironment at single cell resolution. This review aims to discuss these single cell findings in the light of other conventional niche studies that together define the current notion of the niche’s implication in (i) normal hematopoiesis, (ii) myeloid neoplasms and (iii) disease-driving pathways that can be exploited to establish novel therapeutic strategies in the future.

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Dynamic responses of the haematopoietic stem cell niche to diverse stresses

Cited by 104 publications

References 177 publications

Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?

The Bone’s Role in Myeloid Neoplasia

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