Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Yazılıtaş, Fatma; Öztek-Celebi, Fatma Zehra; Erel, Özcan; Çakıcı, Evrim Kargın; Alışık, Murat; Bülbül, Mehmet

doi:10.1159/000496619

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…This hypothesis is supported by the lower albumin levels in children with SSNS and positive correlations between the albumin level and the TT, SH and SS levels. However, the increase in SS/SH and SS/TT ratios in children with SSNS, which are independent of albumin, suggest that TDH shifts towards oxidation in these patients, similar to a previous study 21 . In this context, decreased TT and SH levels in NS patients are not only because of low albumin levels, but also increased oxidative stress.…”

Section: Discussionsupporting

confidence: 88%

“…We found that albumin, TT and SH levels in children with SSNS were lower than in control group. Similarly, Yazılıtaş et al 21 investigated the TDH in children with NS using the new method and found that NS subjects had remarkably lower TT, SH and SS levels when compared with controls. Since albumin makes up the largely portion of the plasma thiol pool, low TT and SH levels can be attributed to low albumin levels in patients with SSNS.…”

Section: Discussionmentioning

confidence: 99%

“…However, the increase in SS/SH and SS/TT ratios in children with SSNS, which are independent of albumin, suggest that TDH shifts towards oxidation in these patients, similar to a previous study. 21 In this context, decreased TT and SH levels in NS patients are not only because of low albumin levels, but also increased oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Impaired thiol/disulphide homoeostasis in children with steroid‐sensitive nephrotic syndrome

2020

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Background Abnormal thiol/disulphide homoeostasis (TDH) is responsible for the pathogenesis of various diseases. We aimed to examine the TDH in children with steroid‐sensitive nephrotic syndrome (SSNS). Methods A total of 131 children, 60 with SSNS and 71 healthy controls, participated in the study. Plasma total thiol (TT), native thiol (SH) and disulphide (SS) levels in the SSNS during remission and control groups were estimated using a new method developed by Erel and Neselioglu. Results Albumin, TT, SH levels and SH/TT ratio were decreased, whereas SS/SH and SS/TT ratios were elevated in SSNS group compared with control group. However, there was no significant difference in SS levels between the two groups. Albumin level was positively correlated with TT, SH and SS levels in the SSNS group. Conclusions We found that TDH shifts in favour of oxidants in children with SSNS in remission. This shift indicates that SSNS patients are exposed to augmented oxidative stress.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Impaired thiol/disulphide homoeostasis in children with steroid‐sensitive nephrotic syndrome

2020

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“…Our results support other investigations showing increased levels of protein oxidation in patients with NS compared with the control group. 21 , 22 For example, Fan et al 21 found higher levels of advanced oxidation protein products and Yazilitas et al 22 observed increased thiol oxidation in patients with NS than in their corresponding controls.…”

Section: Discussionmentioning

confidence: 99%

Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome

et al. 2020

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Objective: Growing evidence shows that oxidative stress plays an important role in the development and progression of nephrotic syndrome (NS). In this study, we aimed to examine serum IMA levels as an indicator of oxidative stress in children with steroid-sensitive NS (SSNS) in remission and relapse. Methods: This cross-sectional study was carried out at the Pediatric Nephrology Unit of Sanliurfa Training and Research Hospital, Sanliurfa, Turkey, from April 2019 to December 2019. In this study Serum IMA and albumin levels were determined in 70 children with SSNS and 45 healthy controls. Among the children with SSNS, 50 were in remission and 20 were in relapse. Then, adjusted IMA levels were calculated from the IMA/albumin ratio. Results: IMA and adjusted IMA levels significantly increased and albumin significantly decreased in children with SSNS in relapse and remission compared with those of the healthy controls. Moreover, these alterations were more prominent in the relapse group than in the remission group. IMA was inversely correlated with albumin in children with SSNS (r= −0.881, p= <0.001). Conclusions: Our findings demonstrated that elevated IMA and adjusted IMA levels observed in patients with SSNS were associated with increased oxidative stress and could indirectly reflect the degree of oxidative damage in glomerular structures. doi: https://doi.org/10.12669/pjms.36.7.2924 How to cite this:Cakirca G, Guzelcicek A, Yilmaz K, Nas C. Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.2924 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Bu dengenin klinik uygulamadaki rolünün araştırıldığı bir derlemede 35 çalışma değerlendirilmiş ve tiyol/disülfit dengesinin vücuttaki koruyucu etkisi olduğu ve birçok hastalıkta tanısal belirteç olarak kullanılabileceği belirtilmiştir 8 . Pediatrik yaş grubunda ise tiyol/disülfit dengesinin polikistik over hastalığı 9 , akut tonsillofarenjit 10 , obezite 11 , atopik dermatit 12 , epilepsi 13 , hipotiroidi 14 , bazı metabolik hastalıklar 15 , hipertansiyon 16 , kafa travması 17 , juvenil idiopatik artrit 18 , febril nöbet 19 , akut böbrek hasarı 20 , nefrotik sendrom 21 , Kawasaki hastalığı 22 ve sepsis 23…”

Section: Gi̇ri̇ş Ve Amaçunclassified

Thiol disulfide balance in children with vitamin B12 deficiency

Okur

Orhan

Elmas

2021

Cukurova Medical Journal

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The aim of this study was to investigate the thiol/disulfide balance as a marker of oxidative stress in children with vitamin B12 deficiency. Materials and Methods: Sixty one pediatric patients with vitamin B12 deficiency and 62 healthy children as a control group was included in the study. Vitamin B12, homocysteine, complete blood count and thiol/disulfide balance parameters of the participants were measured. The relationship between thiol/disulfide balance parameters and vitamin B12 and homocysteine was investigated. Results: The groups were similar in terms of age and gender distribution. Median vitamin B12 level was 179 (98-199) pg/ml in the patient group and 298 (201-965) pg/ml in the control group. Median homocysteine level was 11.2 (0.08-64.3) µmol/L in the patient group and 12 (4.5-26.6) µmol/L in the control group. Median values of homocysteine levels were within the normal range in both groups. Between the patient and control groups; no significant difference was found in terms of homocysteine, native thiol, total thiol, disulfide, disulfide/native thiol ratio, disulfide/total thiol ratio and native thiol/total thiol ratio. There was no significant correlation between thiol/disulfide balance parameters and vitamin B12 and homocysteine levels in the patient and control groups. Conclusion:There was no significant increase in homocysteine level, since the vitamin B12 level was not significantly low in our patient group. It can be predicted that a vitamin B12 deficiency that does not increase homocysteine will not increase oxidative stress and therefore will not increase antioxidant capacity. Amaç: Bu çalışmada, vitamin B12 eksikliği olan çocuklarda oksidatif stres belirteci olarak tiyol/disülfit dengesinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya vitamin B12 eksikliği olan 61 çocuk hasta ve 62 sağlıklı çocuk kontrol grubu olarak dahil edildi. Katılımcıların vitamin B12, homosistein, tam kan sayımı ve tiyol/disülfit dengesi parametreleri ölçüldü. Grupların klinik ve laboratuvar parametreleri karşılaştırıldı. Tiyol/disülfit dengesi parametreleri ile vitamin B12 ve homosistein arasındaki ilişki araştırıldı. Bulgular: Gruplar yaş ve cinsiyet dağılımı açısından benzerdi. Medyan vitamin B12 düzeyi hasta grubunda 179 (98-199) pg/ml, kontrol grubunda 298 (201-965) pg/ml idi. Hasta ve kontrol grubu arasında; homosistein, nativ tiyol, total tiyol, disülfit, disülfit/nativ tiyol oranı, disülfit/total tiyol oranı ve nativ tiyol/total tiyol oranı açısından anlamlı fark saptanmadı. Hasta ve kontrol grubunda, tiyol/disülfit dengesi parametreleri ile vitamin B12 ve homosistein düzeyleri arasında anlamlı korelasyon saptanmadı. Sonuç: Hasta grubumuzda vitamin B12 düzeyinin belirgin düşük olmaması nedeniyle homosistein düzeyinde anlamlı artış olmadığı düşünülmüştür. Homosisteini artırmayan bir vitamin B12 eksikliğinin, oksidatif stresi artırmayacağı, dolayısıyla antioksidan kapasiteyi de artırmayacağı öngörülebilir.

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Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Cited by 6 publications

References 31 publications

Impaired thiol/disulphide homoeostasis in children with steroid‐sensitive nephrotic syndrome

Impaired thiol/disulphide homoeostasis in children with steroid‐sensitive nephrotic syndrome

Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome

Thiol disulfide balance in children with vitamin B12 deficiency

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