Dynamic thiol/disulphide homeostasis in children with febrile seizure

Kurt, Ayşegül Neşe Çıtak; Demir, Hatice; Aydın, Alperen; Erel, Özcan

doi:10.1016/j.seizure.2018.01.012

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Thiol disulfide, disulfid/native thiol, disulfid/total thiol levels were significantly higher in the group with FK history. As a result; higher thiol-disulfide in the FK group and lower native thiol in the FK group suggest that oxidants alter the thiol balance and play an important role in the pathogenesis of FK [19]. Köseoğlu H. et al evaluated the thiol-disulfide homeostasis in patients with acute pancreatitis and found the disulfide/total thiol, disulfid/native thiol ratio higher in the acute pancreatitis group compared to the control group [20].…”

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Ibuprofen on Ischemia-Reperfusion Injury Following Perioperative Tourniquet in Patients Undergoing Total Knee Arthroplasty

Dulkadiroğlu¹,

Aksoy²,

Ugur³

et al. 2021

OJAnes

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Oxidative stress occurs in the organism with ischemia due to tourniquet use and subsequent reperfusion. Oxidative stress increases postoperative morbidity. Some Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) perform their anti-inflammatory effects in part by binding or inhibiting their formation of active oxygen radicals at the site of inflammation. In this study, we aimed to evaluate the effect of IV ibuprofen on ischemia-reperfusion injury (IRI) in patients undergoing total knee arthroplasty over oxidative stress parameters. The patients were randomly divided into two groups. Each patient's protocol number, age, sex, body mass index (BMI), additional disease, drug use, tourniquet time, hemoglobin value, additional analgesic requirement and application, adverse reaction development on the first postoperative day were recorded in the research follow-up form. Both groups of patients; before anesthesia, 45 minutes after tourniquet application, 5 minutes after tourniquet lowering, 20 minutes after tourniquet lowering and at 24th-hour post-op; TOS, TAS, paraoxonase, arylesterase, myeloperoxidase, catalase, ceruloplasmin, albumin, IMA, thiol-disulfide balance tests were studied. Statistical analysis of test results was performed. We observed that antioxidants decreased and oxidants increased on the first postoperative day in both groups in patients who underwent total knee arthroplasty. The decrease in antioxidant parameters was higher in IV ibuprofen doses compared to the control group in the case group; these doses indicate that the drug adversely affects the organism in the fight against oxidative stress, which is an undesirable effect. To evaluate this negative effect of IV ibuprofen which

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Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Ibuprofen on Ischemia-Reperfusion Injury Following Perioperative Tourniquet in Patients Undergoing Total Knee Arthroplasty

Dulkadiroğlu¹,

Aksoy²,

Ugur³

et al. 2021

OJAnes

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“…In the case of decreased NT and TT levels, disulfide/ TT or NT level is also expected to decrease as an indication of an effective antioxidant mechanism 9 . The value of the thiol/disulfide homeostasis was previously studied in infertile men with varicocele, 14 patients undergoing coronary artery bypass grafting, 15 pediatric patients with febrile convulsion, 16 and acute pancreatitis 17 for the prediction of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

The effects of pre‐emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C‐reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial

2021

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Aims In this study, we aimed to investigate the anti‐inflammatory and antioxidant effects of intravenous ibuprofen by using the C‐reactive protein level and thiol/disulfide homeostasis as the oxidative stress marker. Materials and Methods This study was conducted on 70 patients aged between 30 and 65 who were scheduled for elective laparoscopic hysterectomy. The patients were divided into two groups to receive either pre‐emptive 800mg of intravenous ibuprofen plus 1000 mg of intravenous paracetamol (Group IP) or only 1000 mg of intravenous paracetamol as a control group (Group P). The blood samples for thiol/disulfide homeostasis were collected as follows: before induction of anesthesia (T0), before pneumoperitoneum (T1), following postdeflation and discontinuation of anesthesia (T2), and postoperative 24th hour (T3). Simultaneous blood samples for C‐reactive protein (CRP) were also collected. The pre‐ and postoperative urea, creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels were measured. Results A total of 69 patients were included in the study. The patient's characteristics and intraoperative variables were comparable between groups (P > .05). The number of patients requiring rescue analgesia, the total amount of analgesic used, Visual Analog Scale (VAS) scores, and postoperative side effects were significantly lower in Group IP (P < .001). The decrease in native and total thiol levels at T1, T2, and T3 measurement points was significant in Group IP (P < .001). In both groups, the comparison to baseline values demonstrated no significant changes in terms of disulfide level (P > .05). The simultaneous CRP levels indicated a significant increase at the postoperative 24 hour in both groups (P < .001). The difference between groups was insignificant (P > .05). There was a significant increase in urea and creatinine levels in patients of Group IP (P < .05). Conclusion The pre‐emptive administration of ibuprofen provided effective pain control after gynecologic laparoscopy. However, ibuprofen changed the thiol/disulfide homeostasis in favor of oxidation and had no beneficial effect in surgically induced oxidative stress.

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“…Bu dengenin klinik uygulamadaki rolünün araştırıldığı bir derlemede 35 çalışma değerlendirilmiş ve tiyol/disülfit dengesinin vücuttaki koruyucu etkisi olduğu ve birçok hastalıkta tanısal belirteç olarak kullanılabileceği belirtilmiştir 8 . Pediatrik yaş grubunda ise tiyol/disülfit dengesinin polikistik over hastalığı 9 , akut tonsillofarenjit 10 , obezite 11 , atopik dermatit 12 , epilepsi 13 , hipotiroidi 14 , bazı metabolik hastalıklar 15 , hipertansiyon 16 , kafa travması 17 , juvenil idiopatik artrit 18 , febril nöbet 19 , akut böbrek hasarı 20 , nefrotik sendrom 21 , Kawasaki hastalığı 22 ve sepsis 23…”

Section: Gi̇ri̇ş Ve Amaçunclassified

Thiol disulfide balance in children with vitamin B12 deficiency

Okur

Orhan

Elmas

2021

Cukurova Medical Journal

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The aim of this study was to investigate the thiol/disulfide balance as a marker of oxidative stress in children with vitamin B12 deficiency. Materials and Methods: Sixty one pediatric patients with vitamin B12 deficiency and 62 healthy children as a control group was included in the study. Vitamin B12, homocysteine, complete blood count and thiol/disulfide balance parameters of the participants were measured. The relationship between thiol/disulfide balance parameters and vitamin B12 and homocysteine was investigated. Results: The groups were similar in terms of age and gender distribution. Median vitamin B12 level was 179 (98-199) pg/ml in the patient group and 298 (201-965) pg/ml in the control group. Median homocysteine level was 11.2 (0.08-64.3) µmol/L in the patient group and 12 (4.5-26.6) µmol/L in the control group. Median values of homocysteine levels were within the normal range in both groups. Between the patient and control groups; no significant difference was found in terms of homocysteine, native thiol, total thiol, disulfide, disulfide/native thiol ratio, disulfide/total thiol ratio and native thiol/total thiol ratio. There was no significant correlation between thiol/disulfide balance parameters and vitamin B12 and homocysteine levels in the patient and control groups. Conclusion:There was no significant increase in homocysteine level, since the vitamin B12 level was not significantly low in our patient group. It can be predicted that a vitamin B12 deficiency that does not increase homocysteine will not increase oxidative stress and therefore will not increase antioxidant capacity. Amaç: Bu çalışmada, vitamin B12 eksikliği olan çocuklarda oksidatif stres belirteci olarak tiyol/disülfit dengesinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya vitamin B12 eksikliği olan 61 çocuk hasta ve 62 sağlıklı çocuk kontrol grubu olarak dahil edildi. Katılımcıların vitamin B12, homosistein, tam kan sayımı ve tiyol/disülfit dengesi parametreleri ölçüldü. Grupların klinik ve laboratuvar parametreleri karşılaştırıldı. Tiyol/disülfit dengesi parametreleri ile vitamin B12 ve homosistein arasındaki ilişki araştırıldı. Bulgular: Gruplar yaş ve cinsiyet dağılımı açısından benzerdi. Medyan vitamin B12 düzeyi hasta grubunda 179 (98-199) pg/ml, kontrol grubunda 298 (201-965) pg/ml idi. Hasta ve kontrol grubu arasında; homosistein, nativ tiyol, total tiyol, disülfit, disülfit/nativ tiyol oranı, disülfit/total tiyol oranı ve nativ tiyol/total tiyol oranı açısından anlamlı fark saptanmadı. Hasta ve kontrol grubunda, tiyol/disülfit dengesi parametreleri ile vitamin B12 ve homosistein düzeyleri arasında anlamlı korelasyon saptanmadı. Sonuç: Hasta grubumuzda vitamin B12 düzeyinin belirgin düşük olmaması nedeniyle homosistein düzeyinde anlamlı artış olmadığı düşünülmüştür. Homosisteini artırmayan bir vitamin B12 eksikliğinin, oksidatif stresi artırmayacağı, dolayısıyla antioksidan kapasiteyi de artırmayacağı öngörülebilir.

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Dynamic thiol/disulphide homeostasis in children with febrile seizure

Abstract: The fact that the disulphide level was higher and the native thiol level lower in the FS group than the control group suggests that the thiol/disulphide balance may have shifted in favor of oxidants and that oxidants may have a role in FS pathogenesis.

Cited by 8 publications

References 18 publications

Effect of Intravenous Ibuprofen on Ischemia-Reperfusion Injury Following Perioperative Tourniquet in Patients Undergoing Total Knee Arthroplasty

Effect of Intravenous Ibuprofen on Ischemia-Reperfusion Injury Following Perioperative Tourniquet in Patients Undergoing Total Knee Arthroplasty

The effects of pre‐emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C‐reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial

Thiol disulfide balance in children with vitamin B12 deficiency

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