Dynamics of Blood Pressure Elevation and Endothelial Dysfunction in SHR Rats During the Development of Arterial Hypertension

Анищенко, А. М.; Алиев, О. И.; Сидехменова, А. В.; Shamanaev, Aleksandr; Mb, Plotnikov

doi:10.1007/s10517-015-3020-8

Cited by 21 publications

(19 citation statements)

References 13 publications

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“…Vascular reactivity is also regulated by endothelium-dependent relaxation. In this study, we found that endothelium-dependent relaxation was impaired in coronary arteries from SHRs, which is in accordance with previous reports 1 25 . Moreover, treatment of ER stress inhibitor, TUDCA normalized impaired endothelium-dependent relaxation in SHRs.…”

Section: Discussionsupporting

confidence: 94%

Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats

Choi

Lim

Byeon

et al. 2016

Sci Rep

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Endoplasmic reticulum (ER) stress has been shown to play a critical role in the pathogenesis of cardiovascular complications. However, the role and mechanisms of ER stress in hypertension remain unclear. Thus, we hypothesized that enhanced ER stress contributes to the maintenance of hypertension in spontaneously hypertensive rats (SHRs). Sixteen-week old male SHRs and Wistar Kyoto Rats (WKYs) were used in this study. The SHRs were treated with ER stress inhibitor (Tauroursodeoxycholic acid; TUDCA, 100 mg/kg/day) for two weeks. There was a decrease in systolic blood pressure in SHR treated with TUDCA. The pressure-induced myogenic tone was significantly increased, whereas endothelium-dependent relaxation was significantly attenuated in SHR compared with WHY. Interestingly, treatment of ER stress inhibitor normalized myogenic responses and endothelium-dependent relaxation in SHR. These data were associated with an increase in expression or phosphorylation of ER stress markers (Bip, ATF6, CHOP, IRE1, XBP1, PERK, and eIF2α) in SHRs, which were reduced by TUDCA treatment. Furthermore, phosphorylation of MLC20 was increased in SHRs, which was reduced by the treatment of TUDCA. Therefore, our results suggest that ER stress could be a potential target for hypertension.

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Section: Discussionsupporting

confidence: 94%

Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats

Choi

Lim

Byeon

et al. 2016

Sci Rep

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“…SHRs are an animal model of essential hypertension. In SHRs, blood pressure rose to hypertensive levels (above 150 mmHg) from 6 to 12 weeks old (Anishchenko, Aliev, Sidekhmenova, Shamanaev, & Plotnikov, 2015), which was also observed in our lab.…”

Section: Discussionsupporting

confidence: 88%

Serotonergic system may be involved in alterations of sleep homeostasis in spontaneously hypertensive rats

Cui

Huang

Cui

et al. 2019

Journal of Sleep Research

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Evidence from population-based epidemiological studies, experimental sleep deprivation (SD) studies and interventional studies has provided important links between hypertension and sleep disorders (Bruno et al., 2013; Gangwisch, 2014). Hypertension has been shown to be associated with a short sleep duration in both cross-sectional and longitudinal epidemiological studies (Gangwisch, 2014). SD or insufficient sleep can raise blood pressure and lead to structural adaptations that can increase the risk for hypertension (Javaheri,

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“…Tucker and Johnson (21) have shown that 4-day-old SHR rats implanted with a subcutaneous silver wire electrode present an increased adrenergic contribution to heart rate. In fact, the SHR offspring are normotensive at birth (8,9), similarly to normotensive offspring of hypertensive humans (6), but they inherit impaired autonomic heart modulation, as demonstrated in the present study. They were born with higher cardiac sympathetic modulation and increased LF/ HF ratio compared to control neonates.…”

Section: Discussionsupporting

confidence: 72%

“…This reflects an autonomic nervous system dysfunction, which may be described as a loss of homeostasis between sympathetic and parasympathetic functions (7). Moreover, increased sympathetic activity has been largely observed in SHR rats, at least in the early stage of hypertension (8), and the hypertension is often detected in their 3rd-6th week of life (9,10). The animal also presents reduced parasympathetic activity in adult life (11).…”

Section: Introductionmentioning

confidence: 99%

A method to assess heart rate variability in neonate rats: validation in normotensive and hypertensive animals

Freitas

Santos

Arnold

et al. 2020

Braz J Med Biol Res

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Several studies have focused on the heart rate variability (HRV) of murine species, while studies discussing HRV in murine neonates and infants remain scarce, since recording hemodynamic signals through invasive methods in small animals has been found to be quite challenging. Thus, this study aimed at describing and validating a novel method to assess HRV in newborn rats. An electrocardiogram (ECG) system was used to determine RR intervals in awake newborns and evaluate HRV in normotensive (Wistar) and hypertensive (SHR) neonate rats. After birth, ECG was recorded in the awake newborns, and they were allowed to rest on a heated surface, restricted only by the weight of the adhesive ECG electrodes. The electrodes were cut and adapted to provide more comfort to the animal, and gently placed on the newborn's skin. RR intervals were recorded over a 30-min period using an ECG system together with LabChart software (4 KHz). Three sequences of 5 min each from the ECG recording period were analyzed in time and frequency domains, using CardioSeries software. ECG data resulted in a clearly interpretable signal that was used to generate an RR interval sequence through time for the analysis of HRV. SHR neonates presented increased cardiac sympathovagal balance compared to Wistar neonates (low frequency/high frequency: 3.85±0.71 vs 0.90 ± 0.09). In conclusion, the ECG setup here described may be used to record RR intervals to assess HRV in neonate rats, thus detecting early impairment of HRV in hypertensive newborns.

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Dynamics of Blood Pressure Elevation and Endothelial Dysfunction in SHR Rats During the Development of Arterial Hypertension

Cited by 21 publications

References 13 publications

Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats

Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats

Serotonergic system may be involved in alterations of sleep homeostasis in spontaneously hypertensive rats

A method to assess heart rate variability in neonate rats: validation in normotensive and hypertensive animals

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