Dynamics of Spirulina in Promoting Health Benefits for Arsenicosis Patients

Rahman, Muhammad Hasibur; Islam, Azm Maidul; Sikder,

doi:10.3329/jbcps.v26i1.4228

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Spirulina effectively promotes cell rejuvenation and, thereby, repairs liver and kidney tissue damage (Khan et al 2001). In addition, spirulina has a protective effect against arsenic toxicity in humans (Misbahuddin et al 2006;Rahman et al 2008). Therefore, the aim of our investigation was to elucidate the role of the non-invasive oral application of spirulina in the amelioration of high dose arsenic-mediated uterine degeneration.…”

Section: Introductionmentioning

confidence: 99%

Spirulina platensisameliorates arsenic-mediated uterine damage and ovarian steroidogenic disorder

Khatun

Maity

Perveen

et al. 2018

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Novel, non-invasive, painless oral therapeutic agents are needed to replace the painful conventional treatment of arsenic-associated health hazards with metal chelators. Our aim was to examine the effect of spirulina ( Spirulina platensis ( Geitler, 1925 )) on arsenic-mediated uterine toxicity. Female Wistar rats were divided equally into four experimental treatment groups: control group, sodium arsenite group (1.0 mg/100 g body mass), spirulina placebo group (20 mg/100 g body mass), and sodium arsenite + spirulina group. In contrast with the control group, spectrophotometric and electrozymographic evaluation revealed that rats that ingested arsenic for 8 d showed significant diminution of the activities of superoxide dismutase, catalase, and peroxidase ( p < 0.001). Mutagenic uterine DNA breakage and tissue damage were prominent following arsenic consumption by the rats. Oral delivery of spirulina resulted in a significant amelioration of arsenic-induced adverse oxidative stress and genotoxic state of rats. A significant low-signaling ( p < 0.001) of gonadotropins and estradiol was also noted in the arsenic-treated rats, which was terminated by spirulina; this arsenic-primed adverse effect was significant ( p < 0.05, p < 0.01). The spirulina treatment mechanism could be associated with augmentation of the antioxidant defense system that protects the arsenic-mediated pathological state of the uterus.

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Section: Introductionmentioning

confidence: 99%

Spirulina platensisameliorates arsenic-mediated uterine damage and ovarian steroidogenic disorder

Khatun

Maity

Perveen

et al. 2018

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“…Spirulina (Spirulina platensis), a blue-green alga, is rich in protein, phytonutrients, antioxidants, and polysaccharides that might have mitigating effects against heavy metal poisoning. Spirulina has been recommended as a chemoprotective against arsenic-induced toxicity in humans (4,5). It seems reasonable to expect that administration of spirulina might provide a protective mechanism against arsenic-induced toxicity in goats.…”

Section: Introductionmentioning

confidence: 99%

Effects of spirulina in arsenic poisoning in the Black Bengal goat

Ghosh¹,

Awal²,

Khan³

et al. 2014

Turk J Vet Anim Sci

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the uplift of the CAP margins started (Yildirim et al. 2011;Cosentino et al. 2012;Schildgen et al. 2012). Here we describe the type section of the Tuğlu Formation, a sequence exceptionally rich in fossils. The section has been sampled for micropalaeontological (ostracods, foraminifera, pollen, Characeae), palaeontological (molluscs, small mammals, fish remains), environmental magnetism, and stable carbon and oxygen isotope analyses (on ostracods and bulk sediment samples) as well as strontium isotope analyses (on ostracods and foraminifera) and major elements composition of the sediments. Through a highly multidisciplinary approach, we document the Abstract: The Çankırı Basin, located in the northern part of the Central Anatolian Plateau, is a large Tertiary basin where thick Miocene to Quaternary continental sediments overlay the Cretaceous-Tertiary units. This investigation focuses on the Tuğlu Formation, an Upper Miocene succession mainly composed of dark grey silty and organic rich clays. The type section of Tuğlu has been sampled for an array of multidisciplinary analyses. The palaeontological proxies included ostracod, foraminifer, nannoplankton, pollen, molluscs, charophytes, small mammal assemblages, fish, and crab remains. The abiotic parameters studied were: palaeomagnetism and environmental magnetism, stable carbon and oxygen isotope ratios (on ostracods and bulk sediment samples), strontium isotope ratios (on ostracods and foraminifera), and major elemental composition of the sediments. All analysed proxies point to a continental setting characterised by permanent water bodies affected by strong salinity oscillations. A shallow saline lake developed in a permanent freshwater lake. Barren layers, potentially linked to a short subaerial exposure, mark the end of the saline lake and the transition to a fluvial environment. Geochemical analysis confirms aridity-humidity oscillations as recorded by the micropalaeontological proxies. Analysis of small mammal assemblages refined the chronology of the Tuğlu Formation, with the onset of the deposition at the base of the mammal zone MN9 (around 11 Ma) and continuous deposition until the MN11 zone (around 8 Ma). The stable oxygen isotope records from the Tuğlu section point to Miocene δ 18 O water values consistent with subdued topography where no prominent mountain belts were yet developed at the northern plateau margin. If correct, this suggests that at least until the end of the deposition of the Tuğlu Formation, the Çankırı Basin did not yet experience rain shadow conditions, and the regional surface uplift of the area most likely occurred after 8 Ma.

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“…It has been reported that Pc has significant antioxidant and radical scavenging properties, offering protection against oxidative stress 5 . In addition, spirulina plays a protective role against arsenic toxicity in human 6 .…”

Section: Introductionmentioning

confidence: 99%

Combined Dietary Action of Spirulina and Probiotics Mitigates Female Reproductive Ailments in Arsenicated Rats

Khatun¹,

Chatterjee²,

Chattopadhyay³

2019

J Pure Appl Microbiol

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Heavy metals contaminations in food and water are increased due to the environmental pollution. Managing arsenic toxicosis by dietary therapy is yet to be explored, although the conventional therapeutic strategy emphasizes the invasive chelating therapy. In this present study we elucidated the ameliorative effect of Spirulina and probiotics against arsenic-mediated female gonadal injury. The treatment was continued for 8 days (2 estrus cycles) on rats with sodium arsenite (1.0 mg/ 100g body weight) orally, but spirulina (40 mg/100g body weight) and commercially available probiotics mixture (2 mg/ 100g body weight) were added in rat chow, fresh daily. Uterine and ovarian tissue experienced a significant impairment of antioxidant status, while a pronounced ovarian follicular degeneration was apparent from the increased number of follicular atresia in arsenic treated rats. All these deleterious effects of sodium arsenite were diminished significantly by spirulina and probiotics in arsenic fed rat. Moreover, an increase in the serum levels of of homocysteine (Hcy) in association with reduced serum levels of vitamin B 12 and folic acid were mitigated in arsenic fed rats following spirulina and probiotics dietary co-administration. However, the outcome of this study may indicate that spirulina and probiotics may be incorporated in the meal as nutraceuticals in limiting arsenic-mediated health hazards.

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Dynamics of Spirulina in Promoting Health Benefits for Arsenicosis Patients

Cited by 6 publications

References 10 publications

Spirulina platensisameliorates arsenic-mediated uterine damage and ovarian steroidogenic disorder

Spirulina platensisameliorates arsenic-mediated uterine damage and ovarian steroidogenic disorder

Effects of spirulina in arsenic poisoning in the Black Bengal goat

Combined Dietary Action of Spirulina and Probiotics Mitigates Female Reproductive Ailments in Arsenicated Rats

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